Cytoprotective effect of hispidin against palmitate-induced lipotoxicity in C2C12 myotubes

Molecules

Volumn 20, Issue 4, 2015, Pages 5456-5467

  Park, Jun Myoung ^a   Lee, Jong Seok ^a,b   Song, Jeong Eun ^a   Sim, Ye Chan ^a   Ha, Suk Jin ^a   Hong, Eock Kee ^a  

^a Kangwon National University   (South Korea)

^b National Institute of Biological Resources   (South Korea)

Author keywords

C2C12 skeletal muscle cells; Hispidin; Oxidative stress; Phellinus linteus; Type 2 diabetes

Indexed keywords

CASPASE 3; HISPIDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PALMITIC ACID; PROTEIN BAX; PYRONE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL; CELL LINE; CELL PROTECTION; CELL SURVIVAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; OXIDATIVE STRESS; SKELETAL MUSCLE;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; MICE; MUSCLE FIBERS, SKELETAL; NF-KAPPA B; OXIDATIVE STRESS; PALMITIC ACID; PYRONES; REACTIVE OXYGEN SPECIES;

EID: 84928822429     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20045456     Document Type: Article

References (32)

1. Kahn, S.E. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003, 46, 3-19.
2. Weyer, C.; Bogardus, C.; Mott, D.M.; Pratley, R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin. Investig. 1999, 104, 787-794.
3. Bjornholm, M.; Zierath, J.R. Insulin signal transduction in human skeletal muscle: Identifying the defects in type ii diabetes. Biochem. Soc. Trans. 2005, 33, 354-357.
4. Zierath, J.R.; Krook, A.; Wallberg-Henriksson, H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia 2000, 43, 821-835.
5. Ogawa, W.; Matozaki, T.; Kasuga, M. Role of binding proteins to IRS-1 in insulin signalling. Mol. Cell. Biochem. 1998, 182, 13-22.
6. Lam, Y.Y.; Hatzinikolas, G.; Weir, J.M.; Janovska, A.; McAinch, A.J.; Game, P.; Meikle, P.J.; Wittert, G.A. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. Biochim. Biophys. Acta 2011, 1811, 468-475.
7. Peterson, J.M.; Wang, Y.; Bryner, R.W.; Williamson, D.L.; Alway, S.E. Bax signaling regulates palmitate-mediated apoptosis in C2C12 myotubes. Am. J. Physiol: Endocrinol. Metab. 2008, 295, E1307-E1314.
8. Yuzefovych, L.; Wilson, G.; Rachek, L. Different effects of oleate vs. Palmitate on mitochondrial function, apoptosis, and insulin signaling in l6 skeletal muscle cells: Role of oxidative stress. Am. J. Physiol: Endocrinol. Metab. 2010, 299, E1096-E1105.
9. Furukawa, S.; Fujita, T.; Shimabukuro, M.; Iwaki, M.; Yamada, Y.; Nakajima, Y.; Nakayama, O.; Makishima, M.; Matsuda, M.; Shimomura, I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Investig. 2004, 114, 1752-1761.
10. Janssen, Y.M.; Van Houten, B.; Borm, P.J.; Mossman, B.T. Cell and tissue responses to oxidative damage. Lab. Investig. 1993, 69, 261-274.
11. Wei, Y.; Chen, K.; Whaley-Connell, A.T.; Stump, C.S.; Ibdah, J.A.; Sowers, J.R. Skeletal muscle insulin resistance: Role of inflammatory cytokines and reactive oxygen species. Am. J. Physiol: Regul. Integ. Comp. Physiol. 2008, 294, R673-R680.
12. Wyllie, A.H.; Kerr, J.F.; Currie, A.R. Cell death: The significance of apoptosis. Int. Rev. Cytol. 1980, 68, 251-306.
13. Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.
14. Thompson, C.B. Apoptosis in the pathogenesis and treatment of disease. Science 1995, 267, 1456-1462.
15. Fulda, S.; Debatin, K.M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006, 25, 4798-4811.
16. Kern, J.C.; Kehrer, J.P. Free radicals and apoptosis: Relationships with glutathione, thioredoxin, and the bcl family of proteins. Front. Biosci. 2005, 10, 1727-1738.
17. Orrenius, S. Mitochondrial regulation of apoptotic cell death. Toxicol. Lett. 2004, 149, 19-23.
18. Kim, E.J; Park, T.H. Anti-apoptosis engineering. Biotechnol. Bioproc. Eng. 2003, 8, 76-82.
19. Jurgensmeier, J.M.; Xie, Z.; Deveraux, Q.; Ellerby, L.; Bredesen, D.; Reed, J.C. Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Nat. Acad. Sci. USA 1998, 95, 4997-5002.
20. Marsden, V.S.; O'Connor, L.; O'Reilly, L.A.; Silke, J.; Metcalf, D.; Ekert, P.G.; Huang, D.C.; Cecconi, F.; Kuida, K.; Tomaselli, K.J.; et al. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 2002, 419, 634-637.
21. Nicholson, D.W. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell. Death Differ. 1999, 6, 1028-1042.
22. Zhu, T.; Kim, S.H.; Chen, C.Y. A medicinal mushroom: Phellinus linteus. Curr. Med. Chem. 2008, 15, 1330-1335.
23. Lee, S.H.; Oh, I.S.; Kim, Y.I.; Jun, S.C.; So, S.S.; Kim, H.G. Phellinus extracts inhibit migration and matrix metalloproteinase secretion in porcine coronary artery endothelial cells. Biotechnol. Bioproc. Eng. 2007, 12, 100-105.
24. Park, I.H.; Chung, S.K.; Lee, K.B.; Yoo, Y.C.; Kim, S.K.; Kim, G.S.; Song, K.S. An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch. Pharm. Res. 2004, 27, 615-618.
25. Jung, J.Y.; Lee, I.K.; Seok, S.J.; Lee, H.J.; Kim, Y.H.; Yun, B.S. Antioxidant polyphenols from the mycelial culture of the medicinal fungi Inonotus xeranticus and Phellinus linteus. J. Appl. Microbiol. 2008, 104, 1824-1832.
26. Gonindard, C.; Bergonzi, C.; Denier, C.; Sergheraert, C.; Klaebe, A.; Chavant, L.; Hollande, E. Synthetic hispidin, a pkc inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro. Cell. Biol. Toxicol. 1997, 13, 141-153.
27. Olefsky, J.M.; Kolterman, O.G. Mechanisms of insulin resistance in obesity and noninsulin-dependent (type ii) diabetes. Am. J. Med. 1981, 70, 151-168.
28. Lupi, R.; Dotta, F.; Marselli, L.; Del Guerra, S.; Masini, M.; Santangelo, C.; Patane, G.; Boggi, U.; Piro, S.; Anello, M.; et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002, 51, 1437-1442.
29. Gao, X.; Zhao, X.L.; Zhu, Y.H.; Li, X.M.; Xu, Q.; Lin, H.D.; Wang, M.W. Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes. Life Sci. 2011, 88, 803-809.
30. Kannan, K.; Jain, S.K. Oxidative stress and apoptosis. Pathophysiology 2000, 7, 153-163.
31. Conner, E.M.; Grisham, M.B. Inflammation, free radicals, and antioxidants. Nutrition 1996, 12, 274-277.
32. Koshkin, V.; Dai, F.F.; Robson-Doucette, C.A.; Chan, C.B.; Wheeler, M.B. Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells. J. Biol. Chem. 2008, 283, 7936-7948.