Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction

Journal of Natural Products

Volumn 78, Issue 4, 2015, Pages 880-884

  Fonseca Silva, Fernanda ^a   Canto Cavalheiro, Marilene M ^a   Menna Barreto, Rubem F S ^a   Almeida Amaral, Elmo E ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTILEISHMANIAL AGENT; APIGENIN; EPIGALLOCATECHIN GALLATE; GLUTATHIONE; GLUTATHIONE DISULFIDE; QUERCETIN; REACTIVE OXYGEN METABOLITE; ANTIPROTOZOAL AGENT;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL DIVISION; CELL PROLIFERATION; CELL VACUOLE; CONTROLLED STUDY; CRYPTOSPORIDIUM PARVUM; CYTOPLASM; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; ENCEPHALITOZOON INTESTINALIS; ENDOPLASMIC RETICULUM; ENERGY RESOURCE; FLOW CYTOMETRY; IC50; IN VITRO STUDY; LEISHMANIA; LEISHMANIA DONOVANI; LEISHMANIASIS; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROMASTIGOTE; TRANS GOLGI NETWORK; TRANSMISSION ELECTRON MICROSCOPY; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI; ULTRASTRUCTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM;

LEISHMANIA AMAZONENSIS; PROTOZOA;

ACETYLCYSTEINE; ANTIPROTOZOAL AGENTS; APIGENIN; GLUTATHIONE; HUMANS; LEISHMANIA; LEISHMANIASIS; MITOCHONDRIA; MOLECULAR STRUCTURE; REACTIVE OXYGEN SPECIES;

EID: 84928787287     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.5b00011     Document Type: Article

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