Mitochondrial damage contribute to epigallocatechin-3-gallate induced death in Leishmania amazonensis

Experimental Parasitology

Volumn 132, Issue 2, 2012, Pages 151-155

  Inacio, Job D F ^a   Canto Cavalheiro, Marilene M ^a   S Menna Barreto, Rubem F ^a   Almeida Amaral, Elmo E ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Epigallocatechin 3 gallate; Flavonoid; Leishmania amazonensis; Mitochondria; Mitochondrial collapse; Mitochondrial membrane potential ( m)

Indexed keywords

EPIGALLOCATECHIN GALLATE; RHODAMINE 123;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL DAMAGE; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLUORESCENCE ANALYSIS; IC 50; LEISHMANIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; NONHUMAN; PARASITE CULTIVATION; PARASITE VIABILITY; PRIORITY JOURNAL; PROMASTIGOTE; TRANSMISSION ELECTRON MICROSCOPY;

ANTIOXIDANTS; ANTIPROTOZOAL AGENTS; CATECHIN; DOSE-RESPONSE RELATIONSHIP, DRUG; LEISHMANIA MEXICANA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; TIME FACTORS;

LEISHMANIA AMAZONENSIS; PROTOZOA; TRYPANOSOMA CRUZI;

EID: 84866366043     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2012.06.008     Document Type: Article

References (32)

1. Affranchino J.L., De Tarlovsky M.N., Stoppani A.O. Respiratory control in mitochondria from Trypanosoma cruzi. Mol. Biochem. Parasitol. 1985, 16:289-298.
2. Amato V.S., Tuon F.F., Bacha H.A., Neto V.A., Nicodemo A.C. Mucosal leishmaniasis. Current scenario and prospects for treatment. Acta Trop. 2008, 105:1-9.
3. Asres K., Bucar F., Knauder E., Yardley V., Kendrick H., Croft S.L. In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle. Phytother. Res. 2001, 15:613-617.
4. Barral A., Pedral-Sampaio D., Grimaldi G., Momen H., McMahon-Pratt D., Ribeiro de Jesus A., Almeida R., Badaro R., Barral-Netto M., Carvalho E.M. Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. Am. J. Trop. Med. Hyg. 1991, 44:536-546.
5. Chawla B., Madhubala R. Drug targets in Leishmania. J. Parasit. Dis. 2010, 34:1-13.
6. Chen C., Shen G., Hebbar V., Hu R., Owuor E.D., Kong A.N. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 2003, 24:1369-1378.
7. Croft S.L., Coombs G.H. Leishmaniasis-current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol. 2003, 19:502-508.
8. de Souza W., Attias M., Rodrigues J.C. Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida). Int. J. Biochem. Cell Biol. 2009, 41:2069-2080.
9. Desjeux P. Leishmaniasis: current situation and new perspectives. Comp. Immunol. Microbiol. Infect. Dis. 2004, 27:305-318.
10. Fonseca-Silva F., Inacio J.D.F., Canto-Cavalheiro M.M., Almeida-Amaral E.E. Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis. PLoS ONE 2011, 6:e14666.
11. Grimaldi G., Tesh R.B. Leishmaniases of the New World: current concepts and implications for future research. Clin. Microbiol. Rev. 1993, 6:230-250.
12. Guida M.C., Esteva M.I., Camino A., Flawia M.M., Torres H.N., Paveto C. Trypanosoma cruzi: in vitro and in vivo antiproliferative effects of epigallocatechin gallate (EGCg). Exp. Parasitol. 2007, 117:188-194.
13. Higdon J.V., Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr. 2003, 43:89-143.
14. Khan N., Afaq F., Saleem M., Ahmad N., Mukhtar H. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res. 2006, 66:2500-2505.
15. Khouri R., Novais F., Santana G., de Oliveira C.I., Vannier dos Santos M.A., Barral A., Barral-Netto M., Van Weyenbergh J. DETC induces Leishmania parasite killing in human in vitro and murine in vivo models: a promising therapeutic alternative in Leishmaniasis. PLoS ONE 2010, 5:e14394.
16. Luque-Ortega J.R., Rivero-Lezcano O.M., Croft S.L., Rivas L. In vivo monitoring of intracellular ATP levels in Leishmania donovani promastigotes as a rapid method to screen drugs targeting bioenergetic metabolism. Antimicrob. Agents Chemother. 2001, 45:1121-1125.
17. Mehta A., Shaha C. Mechanism of metalloid-induced death in Leishmania spp.: role of iron, reactive oxygen species, Ca2+, and glutathione. Free Radic. Biol. Med. 2006, 40:1857-1868.
18. Menna-Barreto R.F., Henriques-Pons A., Pinto A.V., Morgado-Diaz J.A., Soares M.J., De Castro S.L. Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles. J. Antimicrob. Chemother. 2005, 56:1034-1041.
19. Menna-Barreto R.F., Correa J.R., Pinto A.V., Soares M.J., de Castro S.L. Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from beta-lapachone. Parasitol. Res. 2007, 101:895-905.
20. Menna-Barreto R.F., Goncalves R.L., Costa E.M., Silva R.S., Pinto A.V., Oliveira M.F., de Castro S.L. The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction. Free Radic. Biol. Med. 2009, 47:644-653.
21. Mukherjee P., Majee S.B., Ghosh S., Hazra B. Apoptosis-like death in Leishmania donovani promastigotes induced by diospyrin and its ethanolamine derivative. Int. J. Antimicrob. Agents 2009, 34:596-601.
22. Muzitano M.F., Tinoco L.W., Guette C., Kaiser C.R., Rossi-Bergmann B., Costa S.S. The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata. Phytochemistry 2006, 67:2071-2077.
23. Paveto C., Guida M.C., Esteva M.I., Martino V., Coussio J., Flawia M.M., Torres H.N. Anti-Trypanosoma cruzi activity of green tea (Camellia sinensis) catechins. Antimicrob. Agents Chemother. 2004, 48:69-74.
24. Rodrigues J.C., de Souza W. Ultrastructural alterations in organelles of parasitic protozoa induced by different classes of metabolic inhibitors. Curr. Pharm. Des. 2008, 14:925-938.
25. Rodrigues J.C., Bernardes C.F., Visbal G., Urbina J.A., Vercesi A.E., de Souza W. Sterol methenyl transferase inhibitors alter the ultrastructure and function of the Leishmania amazonensis mitochondrion leading to potent growth inhibition. Protist 2007, 158:447-456.
26. Roy A., Ganguly A., Bosedasgupta S., Das B.B., Pal C., Jaisankar P., Majumder H.K. Mitochondria dependent ROS-mediated programmed cell death (PCD) induced by 3,3'-Diindolylmethane (DIM) through Inhibition of FoF1-ATP synthase in unicellular protozoan parasite Leishmania donovani. Mol. Pharmacol. 2008, 74:1202-1307.
27. Santa-Rita R.M., Lira R., Barbosa H.S., Urbina J.A., de Castro S.L. Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis. J. Antimicrob. Chemother. 2005, 55:780-784.
28. Santos D.O., Coutinho C.E., Madeira M.F., Bottino C.G., Vieira R.T., Nascimento S.B., Bernardino A., Bourguignon S.C., Corte-Real S., Pinho R.T., Rodrigues C.R., Castro H.C. Leishmaniasis treatment - a challenge that remains: a review. Parasitol. Res. 2008, 103:1-10.
29. Sen N., Majumder H.K. Mitochondrion of protozoan parasite emerges as potent therapeutic target: exciting drugs are on the horizon. Curr. Pharm. Des. 2008, 14:839-846.
30. Sen N., Das B.B., Ganguly A., Mukherjee T., Tripathi G., Bandyopadhyay S., Rakshit S., Sen T., Majumder H.K. Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death Differ. 2004, 11:924-936.
31. Sen N., Banerjee B., Das B.B., Ganguly A., Sen T., Pramanik S., Mukhopadhyay S., Majumder H.K. Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex. Cell Death Differ. 2007, 14:358-367.
32. Yang C.S., Maliakal P., Meng X. Inhibition of carcinogenesis by tea. Annu. Rev. Pharmacol. Toxicol. 2002, 42:25-54.