The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction

Free Radical Biology and Medicine

Volumn 47, Issue 5, 2009, Pages 644-653

  Menna Barreto, Rubem F S ^a   Goncalves, Renata L S ^b   Costa, Elaine M ^a   Silva, Raphael S F ^b   Pinto, Antonio V ^b   Oliveira, Marcus F ^b   de Castro, Solange L ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Chagas disease; Chemotherapy; Free radicals; Metabolism; Naphthoquinones; Reactive oxygen species; Superoxide; Trypanosoma cruzi

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2,3 DIHYDRO 2 IODOMETHYLENE 4,5 DIOXONAPHTHO[1,2 B]FURAN; 2,3 DIHYDRO 2 IODOMETHYLENE 4,5 DIOXONAPHTHO[2,3 B]FURAN; 2,3 DIHYDRO 2 METHYL 4,5 DIOXONAPHTHO[1,2 B]FURAN; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RHODAMINE 123; SUCCINIC ACID; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG STRUCTURE; ENZYME ACTIVITY; EPIMASTIGOTE; FLUORESCENCE ACTIVATED CELL SORTING; HOST CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; ULTRASTRUCTURE;

ANIMALS; CELLS, CULTURED; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTRON TRANSPORT; HYDROGEN PEROXIDE; LIFE CYCLE STAGES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MODELS, BIOLOGICAL; NAPHTHOQUINONES; OXIDATIVE STRESS; OXYGEN CONSUMPTION; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 67650738553     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.06.004     Document Type: Article

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