Potential risk of isoflavones: Toxicological study of daidzein supplementation in piglets

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 16, 2015, Pages 4228-4235

  Xiao, Yi ^a   Mao, Xiangbing ^a   Yu, Bing ^a   He, Jun ^a   Yu, Jie ^a   Zheng, Ping ^a   Huang, Zhiqing ^a   Chen, Daiwen ^a  

^a SICHUAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

daidzein; health; piglets; residue; safety

Indexed keywords

ACCIDENT PREVENTION; ANIMALS; DAMAGE DETECTION; DIETARY SUPPLEMENTS; HEALTH; MAMMALS; SAFETY ENGINEERING;

DAIDZEIN; DERIVED PRODUCTS; FEED INGREDIENTS; PIGLETS; POTENTIAL RISKS; RESIDUE; SERUM TESTOSTERONE; SOY ISOFLAVONES;

FLAVONOIDS;

ANIMALIA; SUIDAE;

DAIDZEIN; ISOFLAVONE DERIVATIVE; PLANT EXTRACT;

ANALYSIS; ANIMAL; BODY WEIGHT; CHEMISTRY; DIET SUPPLEMENTATION; FEMALE; GROWTH, DEVELOPMENT AND AGING; LIVER; METABOLISM; PIG; SOYBEAN; SPLEEN; TOXICITY;

ANIMALS; BODY WEIGHT; DIETARY SUPPLEMENTS; FEMALE; ISOFLAVONES; LIVER; PLANT EXTRACTS; SOYBEANS; SPLEEN; SWINE;

EID: 84928740091     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b00677     Document Type: Article

References (44)

1. Larrosa, M.; González-Sarrías, A.; García-Conesa, M. T.; Tomás-Barberán, F. A.; Espín, J. C. Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities J. Agric. Food Chem. 2006, 54, 1611-1620 10.1021/jf0527403
2. Takashima, M.; Nara, K.; Niki, E.; Yoshida, Y.; Hagihara, Y.; Stowe, M.; Horie, M. Evaluation of biological activities of a groundnut (Apios americana Medik) extract containing a novel isoflavone Food Chem. 2013, 138, 298-305 10.1016/j.foodchem.2012.10.100
3. Adams, S. M.; Aksenova, M. V.; Aksenov, M. Y.; Mactutus, C. F.; Booze, R. M. Soy isoflavones genistein and daidzein exert anti-apoptotic actions via a selective ER-mediated mechanism in neurons following HIV-1 Tat1-86 exposure PLoS One 2012, 7, e37540 10.1371/journal.pone.0037540
4. Wijeratne, S. S.; Cuppett, S. L. Soy isoflavones protect the intestine from lipid hydroperoxide mediated oxidative damage J. Agric. Food Chem. 2007, 55, 9811-9816 10.1021/jf071752g
5. Murphy, P.; Farmakalidis, E.; Johnson, L. Isoflavone content of soya-based laboratory animal diets Food Chem. Toxicol. 1982, 20, 315-317 10.1016/S0278-6915(82)80299-8
6. Pediatrics, A. A. o., American Academy of Pediatrics Committee on Nutrition. Soy protein-based formulas: recommendations for use in infant feeding Pediatrics 1998, 101, 148 10.1542/peds.101.1.148
7. Badger, T. M.; Gilchrist, J. M.; Pivik, R. T.; Andres, A.; Shankar, K.; Chen, J.-R.; Ronis, M. J. The health implications of soy infant formula Am. J. Clin. Nutr. 2009, 89, 1668S-1672S 10.3945/ajcn.2009.26736U
8. Barrett, J. R. The science of soy: what do we really know? Environ. Health Persp 2006, 114, A352 10.1289/ehp.114-a352
9. Goldman, L. R.; Newbold, R.; Swan, S. H. Exposure to soy-based formula in infancy JAMA, J. Am. Med. Assoc. 2001, 286, 2402-2403 10.1001/jama.286.19.2402
10. Eldridge, A. C.; Kwolek, W. F. Soybean isoflavones: effect of environment and variety on composition J. Agric. Food Chem. 1983, 31, 394-396 10.1021/jf00116a052
11. Kulling, S. E.; Honig, D. M.; Metzler, M. Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo J. Agric. Food Chem. 2001, 49, 3024-3033 10.1021/jf0012695
12. Wähälä, K.; Hase, T.; Adlercreutz, H. Synthesis and labeling of isoflavone phytoestrogens, including daidzein and genistein Exp. Biol. Med. 1995, 208, 27-32 10.3181/00379727-208-43827
13. Ni, Y.; Zhu, Q.; Zhou, Z.; Grossmann, R.; Chen, J.; Zhao, R. Effect of dietary daidzein on egg production, shell quality, and gene expression of ER-α, GH-R, and IGF-IR in shell glands of laying hens J. Agric. Food Chem. 2007, 55, 6997-7001 10.1021/jf071085r
14. Zhao, R.; Wang, Y.; Zhou, Y.; Ni, Y.; Lu, L.; Grossmann, R.; Chen, J. Dietary daidzein influences laying performance of ducks (Anas platyrhynchos) and early post-hatch growth of their hatchlings by modulating gene expression Comp. Biochem. Physiol., Part A: Mol. Integr. Physiol. 2004, 138, 459-466 10.1016/j.cbpb.2004.06.004
15. Rehfeldt, C.; Adamovic, I.; Kuhn, G. Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny Meat Sci. 2007, 75, 103-111 10.1016/j.meatsci.2006.06.028
16. Strauch, T.; Carroll, J. A Daidzein and Weaned Pig Response to LPS Journal of Animal and Veterinary Advances 2004, 3, 70-73
17. Lamartiniere, C. A.; Wang, J.; Smith-Johnson, M.; Eltoum, I.-E. Daidzein: bioavailability, potential for reproductive toxicity, and breast cancer chemoprevention in female rats Toxicol. Sci. 2002, 65, 228-238 10.1093/toxsci/65.2.228
18. Gilani, G. S.; Farmer, C.; Dyck, M.; Robertson, P.; Dahiya, J.; Sepehr, E.; Fan, L.; Nicolidakis, H.; Curran, I.; Cooke, G. Distribution of isoflavones in samples of serum, liver and mammary glands of rats or pigs fed dietary isoflavones Ann. Nutr. Metab. 2011, 58, 171-180 10.1159/000328771
19. Touchette, K.; Carroll, J.; Allee, G.; Matteri, R.; Dyer, C.; Beausang, L.; Zannelli, M. Effect of spray-dried plasma and lipopolysaccharide exposure on weaned pigs: I. Effects on the immune axis of weaned pigs J. Anim. Sci. 2002, 80, 494-501
20. Zhang, R.; Li, Y.; Wang, W. Enhancement of immune function in mice fed high doses of soy daidzein Nutr. Cancer 1997, 1, 29 10.1080/01635589709514598
21. Kuiper, G. G.; Carlsson, B.; Grandien, K.; Enmark, E.; Haggblad, J.; Nilsson, S.; Gustafsson, J.-a. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β Endocrinology 1997, 138, 863-870 10.1210/en.138.3.863
22. Nynca, A.; Słonina, D.; Jablońska, O.; Kamińska, B.; Ciereszko, R. E. Daidzein affects steroidogenesis and oestrogen receptor expression in medium ovarian follicles of pigs Acta Vet. Hung. 2013, 61, 85-98 10.1556/AVet.2012.060
23. Geary, N.; Asarian, L.; Korach, K. S.; Pfaff, D. W.; Ogawa, S. Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-α null mice Endocrinology 2001, 142, 4751-4757 10.1210/en.142.11.4751
24. Wade, G. N. Sex hormones, regulatory behaviors, and body weight Adv. Stud. Behav. 1976, 6, 201-279
25. Zhao, R.; Zhou, Y.; Ni, Y.; Lu, L.; Tao, Z.; Chen, W.; Chen, J. Effect of daidzein on egg-laying performance in Shaoxing duck breeders during different stages of the egg production cycle Br. Poult. Sci. 2005, 46, 175-181 10.1080/00071660500064808
26. Zhao, X.; Shao, T.; Wang, Y.; Lu, X.; Luo, J.; Zhou, W. The phytoestrogen daidzein may affect reproductive performance of Zhedong White geese by regulating gene mRNA levels in the HPG axis Br. Poult. Sci. 2013, 54, 252-258 10.1080/00071668.2013.767439
27. Genlin, W.; Xiangying, Z.; Zhaoyu, H.; Zhaobin, L.; Weirong, L. Effects of daidzein on body weight gain, serum IGF-I level and cellular immune function in intact male piglets Asian-Australas. J. Anim. Sci. 2002, 15, 1066-1070 10.5713/ajas.2002.1066
28. Higashi, K.; Ogawara, H. Daidzein inhibits insulin-or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells Biochim. Biophys. Acta, Mol. Cell Res. 1994, 1221, 29-35 10.1016/0167-4889(94)90212-7
29. Valeri, A.; Fiorenzani, P.; Rossi, R.; Aloisi, A.; Valoti, M.; Pessina, F. The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder Pharmacol. Res. 2012, 66, 309-316 10.1016/j.phrs.2012.06.007
30. Zhang, L.; Cui, S. Effects of daidzein on testosterone synthesis and secretion in cultured mouse leydig cells Asian-Australas. J. Anim. Sci. 2009, 22, 618-625 10.5713/ajas.2009.80695
31. Alexa, R.; Stochmalova, A.; Kadasi, A.; Grossmann, R.; Kolesarova, A.; Sirotkin, A. The effect of soy phytoestrogen daidzein and fsh on porcine ovarian cell proliferation and steroidogenesis Anim. phys. 2014, 12
32. Liang, J.; Tian, Y.-X.; Fu, L.-M.; Wang, T.-H.; Li, H.-J.; Wang, P.; Han, R.-M.; Zhang, J.-P.; Skibsted, L. H. Daidzein as an antioxidant of lipid: Effects of the microenvironment in relation to chemical structure J. Agric. Food Chem. 2008, 56, 10376-10383 10.1021/jf801907m
33. Draper, H.; Hadley, M. Malondialdehyde determination as index of lipid Peroxidation Methods Enzymol. 1990, 186, 421-431
34. Montagne, L.; Pluske, J.; Hampson, D. A review of interactions between dietary fibre and the intestinal mucosa, and their consequences on digestive health in young non-ruminant animals Anim. Feed Sci. Technol. 2003, 108, 95-117 10.1016/S0377-8401(03)00163-9
35. Ferencz, A.; Nedvig, K.; Fekecs, T.; Rácz, B.; Wéber, G.; Hashimoto, H.; Baba, A.; Helyes, Z.; Reglödi, D. Comparison of Intestinal Cold Preservation Injury on Pituitary Adenylate Cyclase-Activating Polypeptide in Knockout and Wild-Type Mice Transplant. Proc. 2010, 42, 2290-2292 10.1016/j.transproceed.2010.05.014
36. Li, D.; Nelssen, J.; Reddy, P.; Blecha, F.; Hancock, J.; Allee, G.; Goodband, R.; Klemm, R. Transient hypersensitivity to soybean meal in the early-weaned pig J. Anim. Sci. 1990, 68, 1790-1799
37. Shi, S.; Gu, H.; Chang, L.; Wang, Z.; Tong, H.; Zou, J. Safety evaluation of daidzein in laying hens: Part I. Effects on laying performance, clinical blood parameters, and organs development Food Chem. Toxicol. 2013, 55, 684-688 10.1016/j.fct.2013.01.009
38. Kaludjerovic, J.; Chen, J.; Ward, W. E. Early life exposure to genistein and daidzein disrupts structural development of reproductive organs in female mice J. Toxicol. Environ. Health, Part A 2012, 75, 649-660 10.1080/15287394.2012.688482
39. Urpi-Sarda, M.; Morand, C.; Besson, C.; Kraft, G.; Viala, D.; Scalbert, A.; Besle, J.-M.; Manach, C. Tissue distribution of isoflavones in ewes after consumption of red clover silage Arch. Biochem. Biophys. 2008, 476, 205-210 10.1016/j.abb.2008.05.002
40. Gu, L.; House, S. E.; Prior, R. L.; Fang, N.; Ronis, M. J.; Clarkson, T. B.; Wilson, M. E.; Badger, T. M. Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women J. Nutr. 2006, 136, 1215-1221
41. Sepehr, E.; Cooke, G. M.; Robertson, P.; Gilani, G. S. Effect of glycosidation of isoflavones on their bioavailability and pharmacokinetics in aged male rats Mol. Nutr. Food Res. 2009, 53, S16-S26 10.1002/mnfr.200800170
42. King, R. A.; Bursill, D. B. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans Am. J. Clin. Nutr. 1998, 67, 867-872
43. Setchell, K. D.; Faughnan, M. S.; Avades, T.; Zimmer-Nechemias, L.; Brown, N. M.; Wolfe, B. E.; Brashear, W. T.; Desai, P.; Oldfield, M. F.; Botting, N. P. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women Am. J. Clin. Nutr. 2003, 77, 411-419
44. Murkies, A.; Lombard, C.; Strauss, B.; Wilcox, G.; Burger, H.; Morton, M. Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat Maturitas 1995, 21, 189-195 10.1016/0378-5122(95)00899-V