Distribution of isoflavones in samples of serum, liver and mammary glands of rats or pigs fed dietary isoflavones

Annals of Nutrition and Metabolism

Volumn 58, Issue 3, 2011, Pages 171-180

  Gilani, G Sarwar ^a   Farmer, Chantal ^c   Dyck, Monica ^d   Robertson, Patrick ^a   Dahiya, Jagroop ^d   Sepehr, Estatira ^a   Fan, Li ^d   Nicolidakis, Helen ^d   Curran, Ivan ^b   Cooke, Gerard M ^b  

^a Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

^b TOXICOLOGY RESEARCH DIVISION   (Canada)

^c SHERBROOKE RESEARCH AND DEVELOPMENT CENTRE   (Canada)

^d HEALTH CANADA   (Canada)

Author keywords

Liquid chromatography mass spectrometry; Soy isoflavones; Tissue distribution

Indexed keywords

DAIDZEIN; EQUOL; GENISTEIN; GLYCITEIN; ISOFLAVONE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; GENDER; LIQUID CHROMATOGRAPHY; LIVER; MALE; MAMMARY GLAND; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; SERUM; SPECIES DIFFERENCE; SWINE; TISSUE LEVEL;

ANIMALS; BODY WEIGHT; CHROMATOGRAPHY, LIQUID; DIET; DIETARY SUPPLEMENTS; EQUOL; FEMALE; GENISTEIN; ISOFLAVONES; LIVER; MALE; MAMMARY GLANDS, ANIMAL; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY; SOYBEAN PROTEINS; SWINE;

ANIMALIA; RATTUS; SUIDAE;

EID: 79957933482     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000328771     Document Type: Article

References (30)

1. Aldercreuz H, Mazur W: Phytoestrogens and Western disease. Ann Med 1997; 29: 95-120.
2. Cassidy A, Brown JE, Hawdon A, Faughnan MS, King LJ, Millward J, Zimmer-Nechemias L, Wolf B, Setchell KD: Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 2006; 136: 45-51. (Pubitemid 43156483)
3. Setchell KDR: Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 1998; 68: 1333S-1346S. (Pubitemid 28550909)
4. Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N: Phytoestrogen content of foods consumed in Canada including isoflavones, lignans and coumestan. Nutr Cancer 2006; 54: 184-201. (Pubitemid 44316301)
5. Hilakivi-Clarke L, Cho E, Onojafe I, Paygada M, Clark R: Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol Rep 1999; 6: 1089-1095.
6. Hseich CV, Santell RC, Hasiam SZ, Helferich WG: Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in in vitro and in vivo. Cancer Res 1998; 50: 3833-3838. (Pubitemid 28405638)
7. Divi RL, Chang HC, Doerge DR: Identification, characterization and mechanisms of anti-thyroid activity of isoflavones from soybeans. Biochem Pharmacol 1997; 54: 1087-1096. (Pubitemid 27479022)
8. White LR, Petrovitch H, Ross GW, Masaki K, Hardman J, Nelson J, Davis D, Markesbery W: Brain aging and midlife tofu consumption. J Am Coll Nutr 2000; 19: 242-255. (Pubitemid 30185357)
9. Wang HJ, Murphy PA: Isoflavone content in commercial soybean foods. J Agric Food Chem 1994; 42: 1666-1673.
10. King RA: Absorption and metabolism of isoflavones; in Gilani GS, Anderson JB (eds): Phytoestrogens and Health. Chicago, AOCS Press, 2002, pp 209-234.
11. Farmer C, Palin MF, Gilani GS, Weiler H, Vignola M, Choudhary RK, Capuco AV: Dietary genistein stimulates mammary hyperplasia in gilts. Animal 2010; 4: 454-465.
12. Sepehr E, Robertson P, Gilani GS, Cooke GM, Lau BP: An accurate and reproducible method for the quantitative analysis of isoflavones and their metabolites in rat plasma using liquid chromatography/mass spectrometry combined with photodiode array detection. J AOAC Int 2006; 89: 1158-1167. (Pubitemid 44972067)
13. Lewis RW, Brooks N, Milburn GM, Soames A, Stone S, Hall M, Ashby J: The effects of the phytoestrogen genistein on the postnatal development of the rat. Toxicol Sci 2003; 71: 74-83. (Pubitemid 36163707)
14. Agriculture and Agri-Food Canada: Recommended Code of Practice for the Care and Handling of Farm Animals-Pigs. Ottawa, AAFC, 1993.
15. Reeves PG, Nielson FH, Fahey GC Jr: AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993; 123: 1939-1951. (Pubitemid 23342492)
16. Chang HC, Churchwell MI, Delclos KB, Newbold RR, Doerge DR: Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats. J Nutr 2000; 130: 1963-1970. (Pubitemid 30497528)
17. Coldham NG, Sauer MJ: Pharmacokinetics of [ 14 C] genistein in the rat: Gender-related differences, potential mechanisms of biological action, and implications for human health. Toxicol Appl Pharmacol 2000; 164: 206-215. (Pubitemid 30238540)
18. Ullberg S, Bengstsson G: Autoradiographic distribution studies with natural oestrogens. Acta Endocrinol (Copenh) 1963; 43: 75-86.
19. Urpi-Sarda M, Morand C, Besson C, Kraft G, Viala D, Scalbert A, Besle JM, Manach C: Tissue distribution of isoflavones in ewes after consumption of red clover silage. Arch Biochem Biophys 2008; 476: 205-210.
20. Bolca S, Urpi-Sarda M, Blondeel P, Roche N, Vanhaecke L, Possemiers S, Al-Maharik N, Botting N, De Keukeleire D, Bracke M, Heyerick A, Manach C, Depypere H: Disposition of soy isoflavones in normal human breast tissue. Am J Clin Nutr 2010; 91: 976-984.
21. Gu L, House SE, Prior RL, Fang N, Ronis MJ, Clarkson TB, Wilson ME, Badger TM: Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. J Nutr 2006; 136: 1215-1221.
22. Setchell KD, Clerici C, Lephart ED, Cole SJ, Heenan C, Castellani D, Wolfe BE, Nechemiar- Zimmer L, Brown NM, Lund TD, Handa RJ, Heubi JE: S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolites produced by human intestinal bacterial flora. Am J Clin Nutr 2005; 81: 1072-1079. (Pubitemid 41724948)
23. Kuhn G, Hennig U, Kalbe C, Rehfeldt C, Ren MQ, Moors S, Degen GH: Growth performance, carcass characteristics and bioavailability of isoflavones in pigs fed soy bean based diets. Arch Anim Nutr 2004; 58: 265-276. (Pubitemid 39277180)
24. Sepehr E, Cooke GM, Roberson P, Gilani GS: Effect of glycosidation of isoflavones on their bioavailability and pharmacokinetics in aged male rats. Mol Nutr Food Res 2009; 53:S16-26.
25. Izumi T, Pisdkula MK, Osawa S, Obata A, Tobe K, Saito M, Kataoka S, Kubota Y, Kikushi M: Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 2000; 130: 1695-1699 (Pubitemid 30451055)
26. Liu Y, Hu M: Absorption and metabolism of flavonoids in the Caco-2 cell culture model and a perfused rat intestinal model. Drug Metab Dispos 2002; 30: 370-377. (Pubitemid 34263820)
27. Setchell KD, Brown NM, Lydeking-Olsen E: The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 2002; 132: 3577-3584. (Pubitemid 35435031)
28. Vatanparast H, Chilibeck PD: Does the effect of soy phytoestrogens on bone in postmenopausal women depend on the equol producing phenotype? Nutr Rev 2006; 65: 294-299. (Pubitemid 351804364)
29. Penza M, Montani C, Romani A, Vignolini F, Ciana P, Maggi A, Pampaloni B, Caimi L, Lorenzo DI: Genistein accumulates in body depots and is mobilized during fasting, reaching estrogenic levels in serum that counter the hormonal actions of estradiol and organochlorines. Toxicol Sci 2007; 97: 299-307. (Pubitemid 47073847)
30. Labroue F, Guéblez R, Meunier-Salaün MC, Sellier P: Feed intake behaviour of grouphoused Piétrain and Large White growing pigs. Ann Zootech 1999; 48: 247-261. (Pubitemid 129638442)