Genetically encoded fragment-based discovery of glycopeptide ligands for carbohydrate-binding proteins

Journal of the American Chemical Society

Volumn 137, Issue 16, 2015, Pages 5248-5251

  Ng, Simon ^a   Lin, Edith ^a   Kitov, Pavel I ^a   Tjhung, Katrina F ^a   Gerlits, Oksana O ^b   Deng, Lu ^a   Kasper, Brian ^c   Sood, Amika ^d   Paschal, Beth M ^f   Zhang, Ping ^g   Ling, Chang Chun ^g   Klassen, John S ^a   Noren, Christopher J ^f   Mahal, Lara K ^c   Woods, Robert J ^d,e   Coates, Leighton ^b   Derda, Ratmir ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^f NEW ENGLAND BIOLABS   (United States)

^g UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CARBOHYDRATES; LIGANDS; PEPTIDES;

BINDING PROTEINS; CARBOHYDRATE BINDING; CARBOHYDRATE-RECOGNITION DOMAINS; CONSENSUS MOTIF; DERIVATIVE BOUNDS; GUIDE SELECTION; PEPTIDE MOTIFS; X-RAY STRUCTURE;

PROTEINS;

CARBOHYDRATE BINDING PROTEIN; CONCANAVALIN A; GLYCAN; GLYCOPEPTIDE; LECTIN; LIGAND; PEPTIDE; MANNOSE; PEPTIDE LIBRARY; PROTEIN BINDING;

ANALYTIC METHOD; ARTICLE; BACTERIOPHAGE; CHEMICAL BINDING; COMPETITIVE INHIBITION; CONSENSUS; CONTROLLED STUDY; GENETICALLY ENCODED FRAGMENT BASED DISCOVERY; PEPTIDE LIBRARY; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; BINDING SITE; CANAVALIA; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR DOCKING; PROTEIN MOTIF; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CANAVALIA; CONCANAVALIN A; CRYSTALLOGRAPHY, X-RAY; GLYCOPEPTIDES; HUMANS; LIGANDS; MANNOSE; MOLECULAR DOCKING SIMULATION; PEPTIDE LIBRARY; PROTEIN BINDING;

EID: 84928725492     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja511237n     Document Type: Article

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