Discovery of two classes of potent glycomimetic inhibitors of pseudomonas aeruginosa LecB with distinct binding modes

ACS Chemical Biology

Volumn 8, Issue 8, 2013, Pages 1775-1784

  Hauck, Dirk ^a   Joachim, Ines ^a   Frommeyer, Benjamin ^a   Varrot, Annabelle ^b   Philipp, Bodo ^c   Möller, Heiko M ^a   Imberty, Anne ^b   Exner, Thomas E ^a,d   Titz, Alexander ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b Centre National de la Recherche Scientifique   (France)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CARBOHYDRATE; GLYCOMIMETIC INHIBITOR; LECB PROTEIN; LECTIN; MANNOSE; METHYL MANNOSIDE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM ADHERENCE; BINDING ASSAY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; THERMODYNAMICS;

BINDING SITES; BINDING, COMPETITIVE; BIOMIMETICS; CELL ADHESION; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; LECTINS; LIGANDS; MANNOSE; MOLECULAR STRUCTURE; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA;

EID: 84882754814     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400371r     Document Type: Article

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