A strategy for safety assessment of chemicals with data gaps for developmental and/or reproductive toxicity

Regulatory Toxicology and Pharmacology

Volumn 72, Issue 2, 2015, Pages 202-215

  Blackburn, Karen ^a   Daston, George ^a   Fisher, Joan ^a   Lester, Cathy ^a   Naciff, Jorge M ^a   Rufer, Echoleah S ^a   Stuard, Sharon B ^a   Woeller, Kara ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Developmental toxicity; Reproductive toxicity; Risk assessment; Uncertainty factors

Indexed keywords

1,2 DICHLOROETHANE; 1,4 DICHLOROBENZENE; 2,4 DINITROTOLUENE; ACROLEIN; ACRYLIC ACID; ACRYLONITRILE; ALDICARB; AVERMECTIN; BENOMYL; BROMOXYNIL; CARBOFURAN; CARBOSULFAN; CHEMICAL COMPOUND; CHLOROBENZENE; CYFLUTHRIN; CYHALOTHRIN; DICAMBA; ENDOSULFAN; ENDRIN; FORMALDEHYDE; IPRODIONE; METHOMYL; METHOXYCHLOR; MIREX; PROCHLORAZ; PROPICONAZOLE; PROPOXUR; THIRAM; TRIADIMEFON; VINYLIDENE CHLORIDE; DANGEROUS GOODS; TERATOGENIC AGENT;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DATA BASE; DECISION TREE; DEVELOPMENTAL TOXICITY; INFORMATION; NONHUMAN; PRIORITY JOURNAL; RAT; REFERENCE DOSE; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; TOXICOLOGICAL PARAMETERS; UNCERTAINTY FACTOR; ANIMAL; DANGEROUS GOODS; DRUG EFFECTS; EMBRYO DEVELOPMENT; FACTUAL DATABASE; FETUS DEVELOPMENT; HUMAN; NO-OBSERVED-ADVERSE-EFFECT LEVEL; REPRODUCTION; TOXICITY; TOXICITY TESTING; UNCERTAINTY;

ANIMALS; DATABASES, FACTUAL; DECISION TREES; EMBRYONIC DEVELOPMENT; FETAL DEVELOPMENT; HAZARDOUS SUBSTANCES; HUMANS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; REPRODUCTION; RISK ASSESSMENT; TERATOGENS; TOXICITY TESTS; UNCERTAINTY;

EID: 84928719724     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2015.04.006     Document Type: Article

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