Collaborative work on evaluation of ovarian toxicity 5) Two- or four-week repeated-dose studies and fertility study of busulfan in female rats

Journal of Toxicological Sciences

Volumn 34, Issue 1 SPEC. ISS., 2009, Pages

  Sakurada, Yosuke ^a   Kudo, Satoshi ^a   Iwasaki, Shogo ^a   Miyata, Yuki ^a   Nishi, Miyuki ^a   Masumoto, Yoshihiro ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Busulfan; Fertility study; Ovarian toxicity; Primordial follicle; Repeated toxicity study

Indexed keywords

BUSULFAN; CELL NUCLEUS ANTIGEN; ALKYLATING AGENT; BIOLOGICAL MARKER; CYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ESTRUS CYCLE; FEMALE; FEMALE FERTILITY; FEMALE GENITAL SYSTEM; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MATING; MORPHOLOGY; NONHUMAN; OVARY; OVARY FOLLICLE; PREGNANCY; RAT; REPRODUCTIVE TOXICITY; SEXUAL BEHAVIOR; ANIMAL; ANIMAL EMBRYO; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG EFFECT; DRUG SURVEILLANCE PROGRAM; EMBRYO DEATH; FERTILITY; HEALTH CARE ORGANIZATION; JAPAN; MALE; METABOLISM; METHODOLOGY; ORGAN SIZE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

RATTUS;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BIOLOGICAL MARKERS; BUSULFAN; DRUG ADMINISTRATION SCHEDULE; EMBRYO LOSS; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ESTROUS CYCLE; FEMALE; FERTILITY; JAPAN; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; OVARIAN FOLLICLE; OVARY; PREGNANCY; PROLIFERATING CELL NUCLEAR ANTIGEN; PUBLIC-PRIVATE SECTOR PARTNERSHIPS; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, SCIENTIFIC; TOXICITY TESTS;

EID: 64949104269     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.s65     Document Type: Article

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