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Volumn 203, Issue 1-3, 2004, Pages 221-238

Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation

Author keywords

AGD; anogenital distance; DBP; DEHP; di(2 ethylhexyl) phthalate; di n butyl phthalate; FA; flutamide; follicle stimulating hormone; FSH; GD; gestational day; HE; hematoxylin and eosin; LH; LOAEL; lowest observed adverse effect level; luteinizing hormone; MBP

Indexed keywords

FOLLITROPIN; HYPOPHYSIS HORMONE; LUTEINIZING HORMONE; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIBUTYL ESTER; PROLACTIN;

EID: 4444227801     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.06.013     Document Type: Article
Times cited : (124)

References (41)
  • 1
    • 0037772270 scopus 로고    scopus 로고
    • Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate
    • Barlow N.J., Foster P.M. Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate. Toxicol. Pathol. 31:2003;397-410
    • (2003) Toxicol. Pathol. , vol.31 , pp. 397-410
    • Barlow, N.J.1    Foster, P.M.2
  • 4
    • 0017189589 scopus 로고
    • Effect of prolactin and growth hormone on prolactin and LH receptors in the dwarf mouse
    • Bohnet H.G., Friesen H.G. Effect of prolactin and growth hormone on prolactin and LH receptors in the dwarf mouse. J. Reprod. Fertil. 48:1976;307-311
    • (1976) J. Reprod. Fertil. , vol.48 , pp. 307-311
    • Bohnet, H.G.1    Friesen, H.G.2
  • 5
    • 0023002246 scopus 로고
    • Production of sexual steroids in rats during pre- and early postnatal life
    • Csernus V. Production of sexual steroids in rats during pre- and early postnatal life. Exp. Clin. Endocrinol. 88:1986;1-5
    • (1986) Exp. Clin. Endocrinol. , vol.88 , pp. 1-5
    • Csernus, V.1
  • 6
    • 0028846667 scopus 로고
    • A revised critical period for the sexual differentiation of the sexually dimorphic nucleus of the preoptic area in the rat
    • Davis E.C., Shryne J.E., Gorski R.A. A revised critical period for the sexual differentiation of the sexually dimorphic nucleus of the preoptic area in the rat. Neuroendocrinology. 62:1995;579-585
    • (1995) Neuroendocrinology , vol.62 , pp. 579-585
    • Davis, E.C.1    Shryne, J.E.2    Gorski, R.A.3
  • 8
    • 0016240917 scopus 로고
    • Serum LH, FSH, prolactin and progesterone from birth to puberty in female and male rats
    • Döhler K.D., Wuttke W. Serum LH, FSH, prolactin and progesterone from birth to puberty in female and male rats. Endocrinology. 94:1974;1003-1008
    • (1974) Endocrinology , vol.94 , pp. 1003-1008
    • Döhler, K.D.1    Wuttke, W.2
  • 9
    • 0020683322 scopus 로고
    • Leydig cell structure and steroidogenic function
    • Ewing L.L., Zirkin B. Leydig cell structure and steroidogenic function. Recent Prog. Horm. Res. 39:1983;599-635
    • (1983) Recent Prog. Horm. Res. , vol.39 , pp. 599-635
    • Ewing, L.L.1    Zirkin, B.2
  • 10
    • 0031825729 scopus 로고    scopus 로고
    • Tissue-specific induction of 17β-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha
    • Fan L.Q., Cattley R.C., Corton J.C. Tissue-specific induction of 17β-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha. J. Endocrinol. 158:1998;237-246
    • (1998) J. Endocrinol. , vol.158 , pp. 237-246
    • Fan, L.Q.1    Cattley, R.C.2    Corton, J.C.3
  • 11
    • 0036757767 scopus 로고    scopus 로고
    • Neonatal superior ovarian nerve transection disturbs the cyclic activity of the female rats
    • Forneris M.L., Aguado L.I. Neonatal superior ovarian nerve transection disturbs the cyclic activity of the female rats. J. Steroid Biochem. Mol. Biol. 82:2002;75-82
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.82 , pp. 75-82
    • Forneris, M.L.1    Aguado, L.I.2
  • 12
    • 0035025368 scopus 로고    scopus 로고
    • Effects of phthalate esters on the developing reproductive tract of male rats
    • Foster P.M.D., Mylchreest E., Gaido K.W., Sar M. Effects of phthalate esters on the developing reproductive tract of male rats. Hum. Reprod. Updat. 7:2001;231-235
    • (2001) Hum. Reprod. Updat. , vol.7 , pp. 231-235
    • Foster, P.M.D.1    Mylchreest, E.2    Gaido, K.W.3    Sar, M.4
  • 13
    • 0035689374 scopus 로고    scopus 로고
    • Female infertility - Effect of perinatal xenoestrogen exposure on reproductive functions in animals and humans
    • Gotz F., Thieme S., Dorner G. Female infertility - effect of perinatal xenoestrogen exposure on reproductive functions in animals and humans. Folia Histochem. Cytobiol. 2:2001;40-43
    • (2001) Folia Histochem. Cytobiol. , vol.2 , pp. 40-43
    • Gotz, F.1    Thieme, S.2    Dorner, G.3
  • 14
    • 0343090362 scopus 로고    scopus 로고
    • Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p, p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
    • Gray L.E. Jr., Wolf C., Lambright C., Mann P., Price M., Cooper R.L., Ostby J. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p, p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol. Ind. Health. 15:1999;94-118
    • (1999) Toxicol. Ind. Health , vol.15 , pp. 94-118
    • Gray Jr., L.E.1    Wolf, C.2    Lambright, C.3    Mann, P.4    Price, M.5    Cooper, R.L.6    Ostby, J.7
  • 15
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • Gray L.E. Jr., Ostby J., Furr J., Price M., Veeramachaneni D.N., Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Sci. 58:2000;350-365
    • (2000) Toxicol. Sci. , vol.58 , pp. 350-365
    • Gray Jr., L.E.1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.5    Parks, L.6
  • 16
    • 4444296636 scopus 로고    scopus 로고
    • Transgenerational effects of di(2-ethylhexyl) phthalate in the male rat
    • Proceedings of the 42nd annual meeting
    • Gray Jr., L.E., Barlow, N.J., Furr, J.R., Brock, J., Silva, M.J., Barr, D.B., Ostby, J.S., 2003. Transgenerational effects of di(2-ethylhexyl) phthalate in the male rat. In: Proceedings of the 42nd annual meeting. J. Toxicol. Sci., vol. 72, p. 283.
    • (2003) J. Toxicol. Sci. , vol.72 , pp. 283
    • Gray Jr., L.E.1    Barlow, N.J.2    Furr, J.R.3    Brock, J.4    Silva, M.J.5    Barr, D.B.6    Ostby, J.S.7
  • 20
    • 0029146597 scopus 로고
    • A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic
    • Jobling S., Reynolds T., White R., Parker M.G., Sumpter J.P. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103:1995;582-587
    • (1995) Environ. Health Perspect. , vol.103 , pp. 582-587
    • Jobling, S.1    Reynolds, T.2    White, R.3    Parker, M.G.4    Sumpter, J.P.5
  • 22
    • 0024553350 scopus 로고
    • Further evidence that prolactin controls the prepubertal sexual development in the female rat
    • Kawagoe S., Hiroi M. Further evidence that prolactin controls the prepubertal sexual development in the female rat. Gynecol. Obstet. Invest. 27:1989;197-200
    • (1989) Gynecol. Obstet. Invest. , vol.27 , pp. 197-200
    • Kawagoe, S.1    Hiroi, M.2
  • 23
    • 0035912946 scopus 로고    scopus 로고
    • Estradiol enhances the stimulatory effect of FSH on testicular maturation and contributes to precocious initiation of spermatogenesis
    • Kula K., Walczak-Jedrzejowska R., Slowikowska-Hilczer J., Oszukowska E. Estradiol enhances the stimulatory effect of FSH on testicular maturation and contributes to precocious initiation of spermatogenesis. Mol. Cell. Endocrinol. 178:2001;89-97
    • (2001) Mol. Cell. Endocrinol. , vol.178 , pp. 89-97
    • Kula, K.1    Walczak-Jedrzejowska, R.2    Slowikowska-Hilczer, J.3    Oszukowska, E.4
  • 24
    • 0035341453 scopus 로고    scopus 로고
    • Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells
    • Lovekamp T.N., Davis B.J. Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol. Appl. Pharmacol. 172:2001;217-224
    • (2001) Toxicol. Appl. Pharmacol. , vol.172 , pp. 217-224
    • Lovekamp, T.N.1    Davis, B.J.2
  • 25
    • 0037295361 scopus 로고    scopus 로고
    • Mechanisms of phthalate ester toxicity in the female reproductive system
    • Lovekamp-Swan T., Davis B.J. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ. Health Perspect. 111:2003;139-145
    • (2003) Environ. Health Perspect. , vol.111 , pp. 139-145
    • Lovekamp-Swan, T.1    Davis, B.J.2
  • 26
    • 0037471230 scopus 로고    scopus 로고
    • Dual activation of PPARα and PPARγ by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells
    • Lovekamp-Swan T., Jetten A.M., Davis B.J. Dual activation of PPARα and PPARγ by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells. Mol. Cell. Endocrinol. 201:2003;133-141
    • (2003) Mol. Cell. Endocrinol. , vol.201 , pp. 133-141
    • Lovekamp-Swan, T.1    Jetten, A.M.2    Davis, B.J.3
  • 27
    • 0034646988 scopus 로고    scopus 로고
    • Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus
    • Lund T.D., Salyer D.L., Fleming D.E., Lephart E.D. Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus. Brain Res. Dev. Brain Res. 120:2000;261-266
    • (2000) Brain Res. Dev. Brain Res. , vol.120 , pp. 261-266
    • Lund, T.D.1    Salyer, D.L.2    Fleming, D.E.3    Lephart, E.D.4
  • 28
    • 0038601617 scopus 로고
    • NTP technical report on the toxicity studies of dibutyl phthalate (CAS no. 84-74-2) administered in feed to F344/N rats and B6C3F1 mice
    • Marsman, D., 1995. NTP technical report on the toxicity studies of dibutyl phthalate (CAS no. 84-74-2) administered in feed to F344/N rats and B6C3F1 mice. Toxic. Rep. Ser. 30.
    • (1995) Toxic. Rep. Ser. , vol.30
    • Marsman, D.1
  • 29
    • 0142250748 scopus 로고    scopus 로고
    • Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life
    • Masutomi N., Shibutani M., Takagi H., Uneyama C., Takahashi N., Hirose M. Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. Toxicology. 192:2003;149-170
    • (2003) Toxicology , vol.192 , pp. 149-170
    • Masutomi, N.1    Shibutani, M.2    Takagi, H.3    Uneyama, C.4    Takahashi, N.5    Hirose, M.6
  • 30
    • 0842285402 scopus 로고    scopus 로고
    • Dietary influence on the impact of ethinylestradiol-induced alterations in the endocrine/reproductive system with perinatal maternal exposure
    • Masutomi N., Shibutani M., Takagi H., Uneyama C., Hirose M. Dietary influence on the impact of ethinylestradiol-induced alterations in the endocrine/reproductive system with perinatal maternal exposure. Reprod. Toxicol. 18:2004a;23-33
    • (2004) Reprod. Toxicol. , vol.18 , pp. 23-33
    • Masutomi, N.1    Shibutani, M.2    Takagi, H.3    Uneyama, C.4    Hirose, M.5
  • 31
    • 2442488527 scopus 로고    scopus 로고
    • Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals
    • Masutomi N., Shibutani M., Takagi H., Uneyama C., Lee K.Y., Hirose M. Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals. Arch. Toxicol. 78:2004b;232-240
    • (2004) Arch. Toxicol. , vol.78 , pp. 232-240
    • Masutomi, N.1    Shibutani, M.2    Takagi, H.3    Uneyama, C.4    Lee, K.Y.5    Hirose, M.6
  • 32
    • 0031860360 scopus 로고    scopus 로고
    • Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?
    • Mylchreest E., Cattley R.C., Foster P.M. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol. Sci. 43:1998;47-60
    • (1998) Toxicol. Sci. , vol.43 , pp. 47-60
    • Mylchreest, E.1    Cattley, R.C.2    Foster, P.M.3
  • 33
    • 0034021024 scopus 로고    scopus 로고
    • Dose-dependent alteration in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation
    • Mylchreest E., Wallace D.G., Cattley R.C., Foster P.M.D. Dose-dependent alteration in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation. Toxicol. Sci. 55:2000;143-151
    • (2000) Toxicol. Sci. , vol.55 , pp. 143-151
    • Mylchreest, E.1    Wallace, D.G.2    Cattley, R.C.3    Foster, P.M.D.4
  • 34
    • 0036010069 scopus 로고    scopus 로고
    • Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    • Mylchreest E., Sar M., Wallace D.G., Foster P.M. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod. Toxicol. 16:2002;19-28
    • (2002) Reprod. Toxicol. , vol.16 , pp. 19-28
    • Mylchreest, E.1    Sar, M.2    Wallace, D.G.3    Foster, P.M.4
  • 35
    • 0035996072 scopus 로고    scopus 로고
    • Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning
    • Odum J., Lefevre P.A., Tinwell H., Van Miller J.P., Joiner R.L., Chapin R.E., Wallis N.T., Ashby J. Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning. Toxicol. Sci. 68:2002;147-163
    • (2002) Toxicol. Sci. , vol.68 , pp. 147-163
    • Odum, J.1    Lefevre, P.A.2    Tinwell, H.3    Van Miller, J.P.4    Joiner, R.L.5    Chapin, R.E.6    Wallis, N.T.7    Ashby, J.8
  • 37
    • 0031765774 scopus 로고    scopus 로고
    • Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland
    • Sourla A., Martel C., Labrie C., Labrie F. Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland. Endocrinology. 139:1998;753-764
    • (1998) Endocrinology , vol.139 , pp. 753-764
    • Sourla, A.1    Martel, C.2    Labrie, C.3    Labrie, F.4
  • 39
    • 0034075395 scopus 로고    scopus 로고
    • Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the 'Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals
    • Toyoda K., Shibutani M., Tamura T., Koujitani T., Uneyama C., Hirose M. Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the 'Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals. Arch. Toxicol. 74:2000;127-132
    • (2000) Arch. Toxicol. , vol.74 , pp. 127-132
    • Toyoda, K.1    Shibutani, M.2    Tamura, T.3    Koujitani, T.4    Uneyama, C.5    Hirose, M.6
  • 40
    • 0036205620 scopus 로고    scopus 로고
    • Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor
    • You L., Sar M., Bartolucci E.J., McIntyre B.S., Sriperumbudur R. Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor. Toxicol. Sci. 66:2002;216-225
    • (2002) Toxicol. Sci. , vol.66 , pp. 216-225
    • You, L.1    Sar, M.2    Bartolucci, E.J.3    McIntyre, B.S.4    Sriperumbudur, R.5
  • 41
    • 0032418291 scopus 로고    scopus 로고
    • Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters
    • Zacharewski T.R., Meek M.D., Clemons J.H., Wu Z.F., Fielden M.R., Matthews J.B. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol. Sci. 46:1998;282-293
    • (1998) Toxicol. Sci. , vol.46 , pp. 282-293
    • Zacharewski, T.R.1    Meek, M.D.2    Clemons, J.H.3    Wu, Z.F.4    Fielden, M.R.5    Matthews, J.B.6


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