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Volumn 63, Issue 1, 2015, Pages 77-84

Nanoemulsions as delivery systems of hydrophobic silybin from silymarin extract: Effect of oil type on silybin solubility, invitro bioaccessibility and stability

Author keywords

Delivery system; Invitro bioaccessibility; Nanoemulsion; Silybin; Stability

Indexed keywords

CONVERGENCE OF NUMERICAL METHODS; OLIVE OIL; PARTICLE SIZE; SOLUBILITY; SUNFLOWER OIL; SYSTEM STABILITY;

EID: 84928698821     PISSN: 00236438     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lwt.2015.03.091     Document Type: Article
Times cited : (31)

References (42)
  • 1
    • 84855715840 scopus 로고    scopus 로고
    • Nanoemulsion- and emulsion-based delivery systems for curcumin: encapsulation and release properties
    • Ahmed K., Li J., McClements D.J., Xiao H. Nanoemulsion- and emulsion-based delivery systems for curcumin: encapsulation and release properties. Food Chemistry 2012, 132:799-807.
    • (2012) Food Chemistry , vol.132 , pp. 799-807
    • Ahmed, K.1    Li, J.2    McClements, D.J.3    Xiao, H.4
  • 2
    • 0031044521 scopus 로고    scopus 로고
    • Free radical scavenging and anti-oxidative properties of "silybin" complexes on microsomal lipid peroxidation
    • Basaga H., Poli G., Tekkaya C., Ara I. Free radical scavenging and anti-oxidative properties of "silybin" complexes on microsomal lipid peroxidation. Cellular Biochemistry Functionality 1997, 15:27-33.
    • (1997) Cellular Biochemistry Functionality , vol.15 , pp. 27-33
    • Basaga, H.1    Poli, G.2    Tekkaya, C.3    Ara, I.4
  • 4
    • 0029929692 scopus 로고    scopus 로고
    • Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silybin in human cells
    • Dehmlow C., Murawski N., de Groot H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silybin in human cells. Life Sciences 1996, 58(18):1591-1600.
    • (1996) Life Sciences , vol.58 , Issue.18 , pp. 1591-1600
    • Dehmlow, C.1    Murawski, N.2    de Groot, H.3
  • 8
    • 18244374809 scopus 로고    scopus 로고
    • Silybin and its bioavailable phospholipid complex (IdB1016) potentiate in-vitro and in-vivo activity of ciplastin
    • Giacomelli S., Gallo D., Apollonio P., Ferlini C., Distefano M., Morazzoni P., et al. Silybin and its bioavailable phospholipid complex (IdB1016) potentiate in-vitro and in-vivo activity of ciplastin. Life Science 2002, 70:1447-1459.
    • (2002) Life Science , vol.70 , pp. 1447-1459
    • Giacomelli, S.1    Gallo, D.2    Apollonio, P.3    Ferlini, C.4    Distefano, M.5    Morazzoni, P.6
  • 10
    • 84900808214 scopus 로고    scopus 로고
    • Variability in the antioxidant activity of dietary supplements from pomegranate, milk thistle, green tea, grape seed, goji and acai: effect of invitro digestion
    • Henning S.M., Zhang Y., Rontoyanni V.G., Huang J., Lee R.P., Trang A., et al. Variability in the antioxidant activity of dietary supplements from pomegranate, milk thistle, green tea, grape seed, goji and acai: effect of invitro digestion. Journal of Agriculture and Food Chemistry 2014, 62:4313-4321.
    • (2014) Journal of Agriculture and Food Chemistry , vol.62 , pp. 4313-4321
    • Henning, S.M.1    Zhang, Y.2    Rontoyanni, V.G.3    Huang, J.4    Lee, R.P.5    Trang, A.6
  • 11
    • 0000422498 scopus 로고
    • The intraluminal phase of fat digestion in man: the lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption
    • Hofmann A.F., Borgstrom B. The intraluminal phase of fat digestion in man: the lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption. The Journal of Clinical Investigation 1964, 43:247-257.
    • (1964) The Journal of Clinical Investigation , vol.43 , pp. 247-257
    • Hofmann, A.F.1    Borgstrom, B.2
  • 12
    • 79551560585 scopus 로고    scopus 로고
    • Impact of salt and lipid type on invitro digestion of emulsified lipids
    • Hur S.J., Joo S.T., Lim B.O., Decker E.A., McClements J.D. Impact of salt and lipid type on invitro digestion of emulsified lipids. Food Chemistry 2011, 126:1559-1564.
    • (2011) Food Chemistry , vol.126 , pp. 1559-1564
    • Hur, S.J.1    Joo, S.T.2    Lim, B.O.3    Decker, E.A.4    McClements, J.D.5
  • 15
    • 77955053464 scopus 로고    scopus 로고
    • Nanostructured lipid carriers for parenteral delivery of silybin: biodistribution and pharmacokinetic studies
    • Jia L., Zhang D., Li Z., Duan C., Wang Y., Feng F., et al. Nanostructured lipid carriers for parenteral delivery of silybin: biodistribution and pharmacokinetic studies. Colloids and Surfaces Biointerfaces 2010, 80:213-218.
    • (2010) Colloids and Surfaces Biointerfaces , vol.80 , pp. 213-218
    • Jia, L.1    Zhang, D.2    Li, Z.3    Duan, C.4    Wang, Y.5    Feng, F.6
  • 17
    • 80054697161 scopus 로고    scopus 로고
    • Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications
    • Kawabata Y., Wada K., Nakatani M., Yamada S., Onoue S. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. International Journal of Pharmaceutics 2011, 420:1-10.
    • (2011) International Journal of Pharmaceutics , vol.420 , pp. 1-10
    • Kawabata, Y.1    Wada, K.2    Nakatani, M.3    Yamada, S.4    Onoue, S.5
  • 20
    • 53149120602 scopus 로고    scopus 로고
    • Non-invasive headspace measurement for characterizing oxygen-scavenging in polymers
    • Li H., Ashcraft K., Freeman B.D., Stewart M.E., Jank M.K., Clark T.R. Non-invasive headspace measurement for characterizing oxygen-scavenging in polymers. Polymer 2008, 49:4541-4545.
    • (2008) Polymer , vol.49 , pp. 4541-4545
    • Li, H.1    Ashcraft, K.2    Freeman, B.D.3    Stewart, M.E.4    Jank, M.K.5    Clark, T.R.6
  • 21
    • 77954815821 scopus 로고    scopus 로고
    • Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability
    • Li X., Yuan Q., Huang Y., Zhou Y., Liu Y. Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. American Association of Pharmaceutical Science 2010, 11:672-678.
    • (2010) American Association of Pharmaceutical Science , vol.11 , pp. 672-678
    • Li, X.1    Yuan, Q.2    Huang, Y.3    Zhou, Y.4    Liu, Y.5
  • 22
    • 84855194898 scopus 로고    scopus 로고
    • Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: influence of formulation parameters on polymethoxyflavone crystallization
    • Li Y., Zheng J., Xiao H., McClements D.J. Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: influence of formulation parameters on polymethoxyflavone crystallization. Food Hydrocolloids 2012, 27:517-528.
    • (2012) Food Hydrocolloids , vol.27 , pp. 517-528
    • Li, Y.1    Zheng, J.2    Xiao, H.3    McClements, D.J.4
  • 23
    • 79957833378 scopus 로고    scopus 로고
    • Silybin and the liver: from basic research to clinical practice
    • Loguercio C., Festi D. Silybin and the liver: from basic research to clinical practice. World Journal of Gastroenterology 2011, 17:2288-2301.
    • (2011) World Journal of Gastroenterology , vol.17 , pp. 2288-2301
    • Loguercio, C.1    Festi, D.2
  • 24
    • 0032239998 scopus 로고    scopus 로고
    • Areview of plant used in the treatment of liver disease: part 1
    • Luper S. Areview of plant used in the treatment of liver disease: part 1. Alternative Medicine Review 1998, 3:410-421.
    • (1998) Alternative Medicine Review , vol.3 , pp. 410-421
    • Luper, S.1
  • 27
    • 0034492226 scopus 로고    scopus 로고
    • Lipid oxidation in oil-in-water emulsions: impact of molecular environment on chemical reaction in heterogeneous food systems
    • McClements D.J., Decker E.A. Lipid oxidation in oil-in-water emulsions: impact of molecular environment on chemical reaction in heterogeneous food systems. Journal of Food Science 2000, 65:1270-1282.
    • (2000) Journal of Food Science , vol.65 , pp. 1270-1282
    • McClements, D.J.1    Decker, E.A.2
  • 28
    • 33746101105 scopus 로고    scopus 로고
    • Influence of interfacial composition on invitro digestibility of emulsified lipids: potential mechanism for chitosan's ability to inhibit fat digestion
    • Mun S., Decker E.A., Park Y., Weiss J., McClements D.J. Influence of interfacial composition on invitro digestibility of emulsified lipids: potential mechanism for chitosan's ability to inhibit fat digestion. Food Biophysics 2006, 1:21-29.
    • (2006) Food Biophysics , vol.1 , pp. 21-29
    • Mun, S.1    Decker, E.A.2    Park, Y.3    Weiss, J.4    McClements, D.J.5
  • 30
    • 84871732168 scopus 로고    scopus 로고
    • Encapsulation and release of hydrophobic bioactive components in nano-emulsion-based delivery systems: impact of physical form on quercitin bioaccessibility
    • Pool H., Mendoza S., Xiao H., McClements D.J. Encapsulation and release of hydrophobic bioactive components in nano-emulsion-based delivery systems: impact of physical form on quercitin bioaccessibility. Food & Function 2013, 4:162-174.
    • (2013) Food & Function , vol.4 , pp. 162-174
    • Pool, H.1    Mendoza, S.2    Xiao, H.3    McClements, D.J.4
  • 31
    • 84865731585 scopus 로고    scopus 로고
    • Nanoemulsion delivery systems: influence of carrier oil on β-carotene bioacessibility
    • Qian C., Dereck E.A., Xiao H., McClements D.J. Nanoemulsion delivery systems: influence of carrier oil on β-carotene bioacessibility. Food Chemistry 2012, 135:1440-1447.
    • (2012) Food Chemistry , vol.135 , pp. 1440-1447
    • Qian, C.1    Dereck, E.A.2    Xiao, H.3    McClements, D.J.4
  • 32
    • 79952534865 scopus 로고    scopus 로고
    • Formation of nanoemulsions stabilized by model food-grade emulsifiers using high pressure homogenization: factor affecting particle size
    • Qian C., McClements D.J. Formation of nanoemulsions stabilized by model food-grade emulsifiers using high pressure homogenization: factor affecting particle size. Food Hydrocolloids 2011, 25:1000-1008.
    • (2011) Food Hydrocolloids , vol.25 , pp. 1000-1008
    • Qian, C.1    McClements, D.J.2
  • 33
    • 84860606003 scopus 로고    scopus 로고
    • Food-grade microemulsions and nanoemulsions: role of oil phase composition on formation and stability
    • Rao J., McClements D.J. Food-grade microemulsions and nanoemulsions: role of oil phase composition on formation and stability. Food Hydrocolloids 2012, 29:326-334.
    • (2012) Food Hydrocolloids , vol.29 , pp. 326-334
    • Rao, J.1    McClements, D.J.2
  • 34
    • 76749084248 scopus 로고    scopus 로고
    • Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage
    • Shaker E., Mahmoud H., Mnaa S. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food and Chemical Toxicology 2010, 48:803-806.
    • (2010) Food and Chemical Toxicology , vol.48 , pp. 803-806
    • Shaker, E.1    Mahmoud, H.2    Mnaa, S.3
  • 35
    • 0028399265 scopus 로고
    • Rapid, sensitive, iron-based spectrophotometric method for determination of peroxide values of food lipids
    • Shantha N.C., Decker E.A. Rapid, sensitive, iron-based spectrophotometric method for determination of peroxide values of food lipids. Journal of AOAC International 1994, 77:421-424.
    • (1994) Journal of AOAC International , vol.77 , pp. 421-424
    • Shantha, N.C.1    Decker, E.A.2
  • 37
    • 84883400605 scopus 로고    scopus 로고
    • Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and invivo evaluation
    • Yang K.Y., Hwang D.H., Yousaf A.M., Kim D.W., Shin Y.J., Bae O.N., et al. Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and invivo evaluation. International Journal of Nanomedicine 2013, 8:3333-3343.
    • (2013) International Journal of Nanomedicine , vol.8 , pp. 3333-3343
    • Yang, K.Y.1    Hwang, D.H.2    Yousaf, A.M.3    Kim, D.W.4    Shin, Y.J.5    Bae, O.N.6
  • 38
    • 77955057266 scopus 로고    scopus 로고
    • Advances in the pharmaceutical research on the silymarin
    • Yang J., Liu Y.M., Liu Y.Z. Advances in the pharmaceutical research on the silymarin. Natural Product Research 2004, 16:185-187.
    • (2004) Natural Product Research , vol.16 , pp. 185-187
    • Yang, J.1    Liu, Y.M.2    Liu, Y.Z.3
  • 39
    • 84861632327 scopus 로고    scopus 로고
    • Improving the oral bioavailability of curcumin using novel organogel-based nanoemulsion
    • Yu H., Huang Q. Improving the oral bioavailability of curcumin using novel organogel-based nanoemulsion. Journal of Agricultural and Food Chemistry 2012, 60:5373-5379.
    • (2012) Journal of Agricultural and Food Chemistry , vol.60 , pp. 5373-5379
    • Yu, H.1    Huang, Q.2
  • 42
    • 33144454977 scopus 로고    scopus 로고
    • Invitro study of the protective effect of the flavonoid silydianin against reactiver oxygen species
    • Zielinska-Przyjemska M., Wiktorowicz K. Invitro study of the protective effect of the flavonoid silydianin against reactiver oxygen species. Phytotherapy Research 2006, 20:115-119.
    • (2006) Phytotherapy Research , vol.20 , pp. 115-119
    • Zielinska-Przyjemska, M.1    Wiktorowicz, K.2


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