Silymarin-loaded solid nanoparticles provide excellent hepatic protection: Physicochemical characterization and in vivo evaluation

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 3333-3343

  Yang, Kwan Yeol ^a   Hwang, Du Hyeong ^a   Yousaf, Abid Mehmood ^b   Kim, Dong Wuk ^b   Shin, Young Jun ^b   Bae, Ok Nam ^b   Kim, Yong Il ^a   Kim, Jong Oh ^a   Yong, Chul Soon ^a   Choi, Han Gon ^b  

^a Yeungnam University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Enhanced oral bioavailability; Hepatoprotective activity; Nanoparticle; Shirasu porous glass membrane; Silymarin

Indexed keywords

CASTOR OIL; DIETHYLENE GLYCOL MONOETHYL ETHER; GLASS; NANOPARTICLE; POLYSORBATE 80; POVIDONE; SILYMARIN; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ARTIFICIAL MEMBRANE; BIOLOGICAL ACTIVITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SCREENING; DRUG SOLUBILITY; IN VIVO STUDY; LIQUID; LIVER PROTECTION; LIVER TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; PHYSICAL CHEMISTRY; POWDER; PRESSURE; RAT; SOLID STATE; SPRAY DRYING; TEMPERATURE; TIME TO MAXIMUM PLASMA CONCENTRATION; VELOCITY;

ENHANCED ORAL BIOAVAILABILITY; HEPATOPROTECTIVE ACTIVITY; NANOPARTICLE; SHIRASU POROUS GLASS MEMBRANE; SILYMARIN;

ANIMALS; BIOLOGICAL AVAILABILITY; CARBON TETRACHLORIDE; DESICCATION; DIFFUSION; DRUG-INDUCED LIVER INJURY; EMULSIONS; MALE; NANOCAPSULES; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SILYMARIN; TREATMENT OUTCOME;

EID: 84883400605     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S50683     Document Type: Article

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