Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies

International Journal of Pharmaceutics

Volumn 413, Issue 1-2, 2011, Pages 245-253

  Parveen, Rabea ^a   Baboota, Sanjula ^a   Ali, Javed ^a   Ahuja, Alka ^a   Vasudev, Suruchi S ^a   Ahmad, Sayeed ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Hepatoprotective; Nanoemulsion; Oral bioavailability; Pseudoternary phase diagram; Silymarin

Indexed keywords

ALCOHOL; BIOSURFACTANT; GUM ARABIC; NANOCARRIER; OIL; POLYSORBATE 80; SILYBON; SILYMARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIALYSIS MEMBRANE; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIVER PROTECTION; LIVER TOXICITY; NANOEMULSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; FEMALE; NANOPARTICLES; OILS; PARTICLE SIZE; POLYSORBATES; PROTECTIVE AGENTS; RATS; RATS, WISTAR; REFRACTOMETRY; SILYMARIN; SOLUBILITY; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; VISCOSITY;

EID: 79957993239     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.04.041     Document Type: Article

References (32)

1. S. Luper A review of plants used in the treatment of liver diseases: Part 1 Altern. Med. Rev. 3 1998 410 421 (Pubitemid 128709687)
2. N. Dixit, S. Baboota, K. Kohli, S. Ahmad, and J. Ali Silymarin: A review of pharmacological aspects and bioavailability enhancement approaches Indian J. Pharmacol. 39 2007 171 179
3. F. Fraschini, G. Demartini, and D. Esposti Pharmacology of Silymarin Clin. Drug Invest. 22 2002 51 65 (Pubitemid 34151333)
4. S.C. Pradhan, and C. Girish Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine Indian J. Med. Res. 124 2006 491 504 (Pubitemid 46157708)
5. S. Giacomelli, D. Gallo, P. Apollonio, C. Ferlini, M. Distefano, P. Morazzoni, A. Riva, E. Bombardelli, S. Mancuso, and G. Scamvia Silybin and its bioavailable phospholipid complex (IdB1016) potentiate in-vitro and in-vivo activity of cisplatin Life Sci. 70 2002 1447 1459 (Pubitemid 34159100)
6. M. Arcari, A. Brambilla, A. Brandt, R. Caponi, G. Corsi, M. Di Rella, F. Solinas, and W.P. Wachter A new inclusion complex of silibinin and beta-cyclodextrins: in vitro dissolution kinetics and in vivo absorption in comparison with traditional formulations Boll. Chim. Farm. 131 1992 205 209
7. X. Yanyu, S. Yunmei, C. Zhipeng, and P. Qineng The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats Int. J. Pharm. 307 2006 77 82 (Pubitemid 41773254)
8. W. Chen, H. Xia, and W. Wu Optimized preparation of silymarin dripping pills by a central composite design-response surface method Chin. Trad. Herb. Drug 36 2005 679 683
9. J. He, S. Hou, W. Lu, L. Zhu, and J. Feng Preparation, pharmacokinetics and body distribution of silymarin-loaded solid lipid nanoparticles after oral administration J. Biomed. Nanotech. 3 2007 195 202 (Pubitemid 351877170)
10. J.S. Woo, T.S. Kim, J.H. Park, and S.C. Chi Formulation and biopharmaceutical evaluation of silymarin using SMEDDS Arch. Pharm. Res. 30 2007 82 89
11. W. Wei, W. Yang, and Q. Li Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system Eur. J. Pharm. Biopharm. 63 2006 288 294
12. T.W. Leonard, J. Lynch, M.J. McKenna, and D.J. Brayden Promoting absorption of drugs in human's medium chain fatty acid-based solid dosage forms: GIPET™ Exp. Opin. Drug. Deliv. 3 2006 685 692 (Pubitemid 44383494)
13. S. Shafiq-un-Nabi, F. Shakeel, S. Baboota, J. Ali, A. Ahuja, R.K. Khar, and M. Ali Development and optimization using nanoemulsion technique: A technical note AAPS Pharm. Sci. Tech. 8 2002 10.1208/pt0802028 Article 28
14. W. Mehnert, and K. Mader Solid lipid nanoparticles: production, characterization and applications Adv. Drug Deliv. Rev. 47 2001 165 196 (Pubitemid 32324113)
15. V. Bali, M. Ali, and J. Ali Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe Coll. Surf. B: Biointerf. 76 2010 410 420
16. S. Shafiq, F. Shakeel, S. Talegaonkar, F.J. Ahmad, R.K. Khar, and M. Ali Development and bioavailability assessment of ramipril nanoemulsion formulation Eur. J. Pharm. Biopharm. 66 2007 227 243 (Pubitemid 46667230)
17. F. Shakeel, S. Baboota, A. Ahuja, J. Ali, M. Aqil, and S. Shafiq Nanoemulsions as vehicles for transdermal delivery of aceclofenac AAPS Pharm. Sci. Tech. 8 4 2007 E1 E9 10.1208/pt0804104 Article 104
18. N. Chennamsetty, H. Bock, L.F. Scanu, F.R. Siperstein, and K.E. Gubbins Cosurfactant and cosolvent effects on surfactant self-assembly in supercritical carbon dioxide J. Chem. Phys. 122 2005 094710 094711
19. M.J. Lawrence, and G.D. Rees Microemulsion-based media as novel drug delivery systems Adv. Drug Deliv. Rev. 45 2000 89 121
20. L. Ping, A. Ghosh, R.F. Wagner, S. Krill, Y.M. Joshi, and A.T.M. Serajuddin Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions Int. J. Pharm. 288 2005 27 34 (Pubitemid 39656452)
21. R. Parveen, S. Baboota, J. Ali, A. Ahuja, and S. Ahmad Stability-indicating HPTLC method for quantitative estimation of silybin in bulk drug, pharmaceutical dosage form and biological samples Biomed. Chromatogr. 24 2010 639 647
22. R.O. Racknagel, E.E. Glende, J.A. Dolak, and R.L. Waller Mechanisms of carbon tetrachloride toxicity Pharmacol. Ther. 43 1989 134 154
23. S. Reitman, and S. Frankel A colorimetric method for the determination of serum glutamic oxoloacetic and glutamic pyruvic transaminase Am. J. Clin. Pathol. 28 1957 56 63
24. O.A. Bessey, D.H. Lowery, and M.J. Brock A method for the rapid determination of alkaline phosphatase with five cubic meters of serum J. Biol. Chem. 164 1964 321 329
25. R. Holm, C.J.H. Porter, A. Müllertz, H.G. Kristensen, and W.N. Charman Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats Pharm. Res. 19 2002 1354 1361
26. P.K. Gosh, and R.S.R. Murthy Microemulsions: a potential drug delivery system Curr. Drug Deliv. 3 2006 167 180 (Pubitemid 43725014)
27. R. Razdan, and P.V. Deverajan Microemulsion - a review Indian Drugs 40 2003 139 146
28. D. Lorenz, P.W. Lucker, W.H. Mennicke, and N. Wetzelsberger Pharmacokinetics studies with silymarin in human serum and bile Meth. Find. Exptl. Clin. Pharmacol. 6 1984 655 661 (Pubitemid 15217352)
29. P. Morazzoni, A. Montalbetti, S. Malandrino, and G. Pifferi Comparative pharmacokinetics of silipide and silymarin in rats Eur. J. Drug Metab. Pharmacokinet. 18 1993 289 297 (Pubitemid 24009653)
30. S.C. Chi Enhanced dissolution rate of biphenyl dimethyl dicarboxylate using SMEDDS B. T. Gattefosse. 92 1999 75 80
31. P.M. Hall, J.L. Plummer, A.H. Ilsley, and M.J. Cousins Hepatic fibrosis and cirrhosis after chronic administration of alcohol and "lowdose" carbon tetrachloride vapor in the rat Hepatology 13 1991 815 881
32. S. Abrol, A. Trehan, and O.P. Katare Comparative study of different silymarin formulations: formulation, characterization and in vitro/in vivo evaluation Curr. Drug Deliv. 2 2005 45 51 (Pubitemid 40590920)