Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

European Journal of Nutrition

Volumn 55, Issue 3, 2016, Pages 955-965

  Kubatka, Peter ^a   Kapinová, Andrea ^b   Kello, Martin ^c   Kruzliak, Peter ^d   Kajo, Karol ^e   Výbohová, Desanka ^b   Mahmood, Silvia ^b   Murin, Radovan ^b   Viera, Tischlerová ^c   Mojžiš, Ján ^c   Zulli, Anthony ^f   Péč, Martin ^a   Adamkov, Marián ^b   Kassayová, Monika ^c   Bojková, Bianka ^c   Stollárová, Nadežda ^g   Dobrota, Dušan ^b  

^a University Teaching Hospital in Martin   (Slovakia)

^b Physics and Informatics   (Slovakia)

^c P J AFÁRIK UNIVERSITY   (Slovakia)

^d ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^e SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^f VICTORIA UNIVERSITY   (Australia)

^g CATHOLIC UNIVERSITY IN RU OMBEROK   (Slovakia)

Author keywords

Angiogenesis; Apoptosis; Cell proliferation; Fruit polyphenols; Mammary carcinogenesis; MCF 7; Rat

Indexed keywords

CARCINOGEN; CASPASE 3; FLAVIN 7; KI 67 ANTIGEN; LIPID; LIPOCORTIN 5; METHYLNITROSOUREA; POLYPHENOL; PROTEIN BCL 2; QUERCETIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; 3-NITROTYROSINE; ANTINEOPLASTIC AGENT; BAX PROTEIN, RAT; CASP3 PROTEIN, RAT; FLAVIN7; FLAVONOID; KDR PROTEIN, RAT; PROTEIN BAX; STILBENE DERIVATIVE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; BREAST TUMOR; CANCER INCIDENCE; CARCINOGENESIS; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DIET; DNA FRAGMENTATION; DRUG MEGADOSE; FEMALE; FRUIT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LATENT PERIOD; LIPID BLOOD LEVEL; LIPID METABOLISM; MCF 7 CELL LINE; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELL LINE; METABOLISM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAVONOIDS; FRUIT; HUMANS; KI-67 ANTIGEN; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; METHYLNITROSOUREA; POLYPHENOLS; RATS; STILBENES; TYROSINE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84928658549     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-0910-5     Document Type: Article

References (32)

1. Yochum L, Kushi LH, Meyer K, Folsom AR (1999) Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am J Epidemiol 149:943–949
2. Willett WC (1994) Micronutrients and cancer risk. Am J Clin Nutr 59:1162S–1165S
3. Hu FB, Willett WC (2002) Optimal diets for prevention of coronary heart disease. JAMA 288:2569–2578
4. Yiannakopoulou ECH (2014) Effect of green tea catechins on breast carcinogenesis: a systematic review of in vitro and in vivo experimental studies. Eur J Cancer Prev 3:84–89
5. Cutler GJ, Nettleton JA, Ross JA, Harnack LJ, Jacobs DR Jr, Scrafford CG et al (2008) Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women’s Health Study. Int J Cancer 23:664–671
6. Fink N, Steck SE, Wolff MS, Britton JA, Kabat GC, Gaudet MM et al (2007) Dietary flavonoid intake and breast cancer survival among women on Long Island. Cancer Epidemiol Biomarkers Prev 16:2285–2292
7. Neuhouser ML (2004) Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer 50:1–7
8. Sun M, Nie S, Pan X, Zhang R, Fan Z, Wang S (2014) Quercetin-nanostructured lipid carriers: characteristics and anti-breast cancer activities in vitro. Collid Surf B 113:15–24
9. Purushothaman A, Nandhakumar E, Sachdanandam P (2013) Phytochemical analysis and anticancer capacity of Shemamruthaa, a herbal formulation against DMBA- induced mammary carcinoma in rats. Asian Pac J Trop Med 6:925–933
10. Roy S, Banerjee B, Vedasiromoni JR (2014) Cytotoxic and apoptogenic effect of Swietenia mahagoni (L.) Jacq. leaf extract in human leukemic cell lines U937, K562 and HL-60. Environ Toxicol Pharmacol 37:234–247
11. Li Y, Duan S, Jia H, Bai C, Zhang L, Wang Z (2014) Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells. Acta Biochim Biophys Sin (Shanghai) 46:460–470
12. Zhang Y, Li Q, Ge Y, Chen Y, Chen J, Dong Y, Shi W (2013) Silibinin triggers apoptosis and cell-cycle arrest of SGC7901 cells. Phytother Res 27:397–403
13. Russo J, Russo IH (2000) Atlas and histologic classification of tumors of the rat mammary gland. J Mammary Gland Biol Neoplasia 5:187–200
14. Murín R, Drgová A, Kaplán P, Dobrota D, Lehotský J (2001) Ischemia/Reperfusion-induced oxidative stress causes structural changes of brain membrane proteins and lipids. Gen Physiol Biophys 20:431–438
15. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63
16. Kisková T, Jendželovský R, Rentsen E, Maier-Salamon A, Kokošová N, Papčová Z et al (2014) Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. Eur J Cancer Prev 23:506–513
17. Kisková T, Ekmekcioglu C, Garajová M, Orendáš P, Bojková B, Bobrov N et al (2012) A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Eur J Cancer Prev 21:163–170
18. Bilotto S, Spagnuolo C, Russo M, Tedesco I, Laratta B, Russo GL (2013) Dietary phytochemicals in chemoprevention of cancer: an update. IEMAMC 13:2–24
19. Russo GL (2007) Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 74:533–544
20. Ziegler CC, Rainwater L, Whelan J, McEntee MF (2004) Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 134:5–10
21. Kubatka P, Kapinová A, Kružliak P, Kello M, Výbohová D, Kajo K, Novák M, Chripková M, Adamkov M, Péč M, Mojžiš J, Bojková B, Kassayová M, Stollárová N, Dobrota D (2015) Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model. Nutrition 31:560–569
22. Zhang J, Park HS, Kim JA, Hong GE, Nagappan A, Park KI, Kim GS (2014) Flavonoids identified from korean Scutellaria baicalensis induce apoptosis by ROS generation and caspase activation on human fibrosarcoma cells. Am J Chin Med 42:465–483
23. Sudan S, Rupasinghe HP (2014) Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells. Nutr Cancer 66:1237–1246
24. Oh SB, Hwang C, Song SY, Jung YY, Yun HM, Sok C et al (2014) Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3. Cancer Lett 353:95–103
25. Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, Yoon JH et al (2014) HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells. Int J Oncol 44:473–480
26. Chen ZT, Tao ZZ, Chen SM, Chen C, Li F, Xiao BK (2013) Indole-3-carbinol inhibits nasopharyngeal carcinoma growth through cell cycle arrest in vivo and in vitro. PLoS One 8:e82288
27. Cserni G, Voeroes A, Liepniece-Karele I, Bianchi S, Vezzosi V, Grabau D et al (2014) Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values. Breast 23:259–263
28. Wang Z, Wang N, Han S, Wang D, Mo S, Yu L et al (2013) Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One 8:e68566
29. Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S et al (2013) A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep 30:2357–2364
30. Mojžiš J, Šarisský M, Pilátová M, Voharová V, Varinská L, Mojzisová G et al (2008) In vitro antiproliferative and antiangiogenic effects of Flavin7. Physiol Res 57:413–420
31. Hussain SP, Lorne J, Harris CC (2003) Radical causes of cancer. Nat Rev Cancer 3:276–284
32. Malencik DA, Anderson SR (2003) Dityrosine as a product of oxidative stress and fluorescent probe. Amino Acids 25:233–247