In vitro antiproliferative and antiangiogenic effects of Flavin7®

Physiological Research

Volumn 57, Issue 3, 2008, Pages 413-420

  Mojzis, Jan ^a   Sarissky M ^a   Pilatova M ^a   Voharova V ^a   Varinska L ^a   Mojzisova G ^a   Ostro, A ^a   Urdzik P ^a   Dankovcik R ^a   Mirossay, L ^a  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

Author keywords

Antiangiogenic; Antiproliferative; Flavin7; Polyphenols

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; FLAVIN7; FLAVONOID; GELATINASE B; PROTEINASE INHIBITOR; RIBOFLAVIN DERIVATIVE; STILBENE DERIVATIVE;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; DIET SUPPLEMENTATION; DNA FRAGMENTATION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; ENZYMOLOGY; HELA CELL; HUMAN; LEUKEMIA CELL LINE; PATHOLOGY;

ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DIETARY SUPPLEMENTS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FLAVINS; FLAVONOIDS; HELA CELLS; HUMANS; JURKAT CELLS; MATRIX METALLOPROTEINASE 9; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEASE INHIBITORS; STILBENES;

EID: 45849144088     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. AHMAD KA, HARRIS NH, JOHNSON AD, LINDVALL HC, WANG G, AHMED K. Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3- gallate in prostate cancer cells. Mol Cancer Ther 6: 1006-1012, 2007.
2. CAVALLARO A, AINIS T, BOTTARI C, FIMIANI V: Effect of resveratrol on some activities of isolated and in whole blood human neutrophils. Physiol Res 52: 555-562, 2003.
3. CHEUNG KJ, LI G: The tumour suppressor p33ING1 does not regulate migration and angiogenesis in melanoma cells. Int J Oncol 21: 1361-1365, 2002.
4. COLLEN A, HANEMAAIJER R, LUPU F, QUAX PH, VAN LENT N, GRIMBERGEN J, PETERS E, KOOLWIJK P, VAN HINSBERGH VW: Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix. Blood 101:1810-1817, 2003.
5. DAS A, BANIK NL, RAY SK. Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. Int J Cancer 119: 2575-2585, 2006.
6. FOLKMAN J: Angiogenesis inhibitors: a new class of drugs. Cancer Biol Ther 2 (Suppl 1): S127-S133, 2003.
7. FOLKMAN J. Angiogenesis. Annu Rev Med 57: 1-18, 2006.
8. FOTSIS T, PEPPER MS, AKTAS E, BREIT S, RASKU S, ADLERCREUTZ H, WAHALA K, MONTESANO R, SCHWEIGERER L: Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57: 2916-2921, 1997.
9. GRANADO-SERRANO AB, MARTIN MA, BRAVO L, GOYA L, RAMOS S. Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr 136: 2715-2721, 2006.
10. GERRITSEN ME: Flavonoids: inhibitors of cytokine induced gene expression. Adv Exp Med Biol 439: 183-190, 1998.
11. IOANNIDES C, YOXALL V: Antimutagenic activity of tea: role of polyphenols. Curr Opin Clin Nutr Metab Care 6: 649-656, 2003.
12. KANADASWAMI C, LEE LT, LEE PP, HWANG JJ, KE FC, HUANG YT, LEE MT: The antitumor activities of flavonoids. In Vivo 19: 895-909, 2005.
13. LI M, ZHANG Z, HILL DL, CHEN X, WANG H, ZHANG R: Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels. Cancer Res 65: 8200-8208, 2005.
14. LI Y, LIU J, LIU X, XING K, WANG Y, LI F, YAO L. Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Appl Biochem Biotechnol 135: 181-192, 2006.
15. MAK P, LEUNG YK, TANG WY, HARWOOD C, HO SM. Apigenin suppresses cancer cell growth through ERbeta. Neoplasia 8: 896-904, 2006.
16. MARIN V, KAPLANSKI G, GRES S, FARNARIER C, BONGRAND P: Endothelial cell culture: protocol to obtain and cultivate human umbilical endothelial cells. J Immunol Methods 254: 183-190, 2001.
17. MOSMANN T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
18. NAM RK, FLESHNER N, RAKOVITCH E, KLOTZ L, TRACHTENBERG J, CHOO R, MORTON G, DANJOUX C: Prevalence and patterns of the use of complementary therapies among prostate cancer patients: An epidemiological analysis. J Urol 161: 1521-1524, 1999.
19. NEWCOMB EW, ALI MA, SCHNEE T, LAN L, LUKYANOV Y, FOWKES M, MILLER DC, ZAGZAG D. Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy. Neuro Oncol 7: 225-235, 2005.
20. OAK MH, EL BEDOUI J, SCHINI-KERTH VB: Antiangiogenic properties of natural polyphenols from red wine and green tea. J Nutr Biochem 16: 1-8, 2005.
21. RISBERG T, LUND E, WIST E, KAASA S, WILSGAARD T: Cancer patients' use of non-proven therapy: a 5-year follow-up study. J Clin Oncol 16: 6-12, 1998.
22. TAN WF, LIN LP, LI MH, ZHANG YX, TONG YG, XIAO D, DING J: Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol 459: 255-262, 2003.
23. VIJAYABABU MR, ARUNKUMAR A, KANAGARAJ P, VENKATARAMAN P, KRISHNAMOORTHY G, ARUNAKARAN J: Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem 287: 109-116, 2006.