Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells

Acta Biochimica et Biophysica Sinica

Volumn 46, Issue 6, 2014, Pages 460-470

  Li, Yuying ^a   Duan, Shizhao ^a   Jia, Haiyan ^a   Bai, Chongzhi ^b   Zhang, Liwei ^a   Wang, Zhuanhua ^a  

^a SHANXI UNIVERSITY   (China)

^b Shanxi Institute of Traditional Chinese Medicine   (China)

Author keywords

Anticancer; Buckwheat's flavonoids; Cell cycle; p53; ROS

Indexed keywords

ANTIOXIDANT; FLAVONOID; PRIMER DNA; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CELL CYCLE G2 PHASE; CELL DIVISION; DRUG EFFECTS; FLOW CYTOMETRY; HUMAN; LIVER CELL CARCINOMA; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANTIOXIDANTS; APOPTOSIS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL LINE, TUMOR; DNA PRIMERS; FLAVONOIDS; FLOW CYTOMETRY; G2 PHASE; HUMANS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84901649320     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmu023     Document Type: Article

References (32)

1. Harborne JB and Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2000, 55: 481-504
2. Li N, Liu JH, Zhang J and Yu BY. Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids. J Agric Food Chem 2008, 56: 3876-3883. (Pubitemid 351860197)
3. Hanneken A, Lin FF, Johnson J and Maher P. Flavonoids protect human retinal pigment epithelial cells from oxidative stress-induced death. Invest Ophthalmol Via Sci 2006, 47: 3164-3177. (Pubitemid 351639797)
4. Han RM, Tian YX, Liu Y, Chen CH, Ai XC, Zhang JP and Skibsted LH. Comparison of flavonoids and isoflavonoids as antioxidants. J Agric Food Chem 2009, 57: 3780-3785
5. Nishimura J, Saegusa Y, Dewa Y, Jin M, Kawai M, Kemmochi S and Harada T, et al. Antioxidant enzymatically modified isoquercetin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats. Arch Toxicol 2010, 84: 143-153
6. Guo DD, Wu CH, Li JY, Guo AR, Li QN, Jiang H and Chen BA, et al. Synergistic effect of functionalized nickel nanoparticles and quercetin on inhibition of the SMMC-7721 cells proliferation. Nanoscale Res Lett 2009, 4: 1395-1402
7. Paula CZ, Teresa F, Paula AA, Victoria C, Sofia G, Eloisi CL and Marcelo W, et al. Ligaria cuneifolia flavonoid fractions modulate cell growth of normal lymphocytes and tumor cells as well as multidrug resistant cells. Immunobiology 2005, 209: 737-749
8. Li D, Li XL and Ding XL. Composition and antioxidative properties of the flavonoid-rich fractions from tartary buckwheat grains. Food Sci Biotechnol 2010, 19: 711-716
9. Skrabanja V, Liljeberg Elmstahl HG, Kreft I and Bjorck IM. Nutritional properties of starch in buckwheat products: Studies in vitro and in vivo. J Agric Food Chem 2001, 49: 490-496. (Pubitemid 32104553)
10. Li YY, Zhang Z, Wang ZH, Wang HW, Zhang L and Zhu L. rBTI induces apoptosis in human solid tumor cell lines by loss in mitochondrial transmembrane potential and caspase activation. Toxicol Lett 2009, 18: 166-175
11. Li YQ, Yang P, Gao F, Zhang ZW and Wu B. Probing the interaction between 3 flavonoids and pancreatic lipase by methods of fluorescence spectroscopy and enzymatic kinetics. Eur Food Res Technol 2011, 233: 63-69
12. Ren W, Qiao Z, Wang H, Zhu L and Zhang L. Flavonoids: Promising anticancer agents. Med Res Rev 2003, 23: 519-534. (Pubitemid 36706514)
13. Casgrande F and Darbon JM. Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclindependent kinases CDK2 and CDK1. Biochem Pharmacol 2000, 61: 1205-1215
14. Ficarra R, Tommasini S, Raneri D, Calabro ML, Di Bella MR, Rustichelli C and Gamberini MC, et al. Study of flavonoids/betacyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation. J Pharmaceutic Biomed Anal 2002, 29: 1005-1014. (Pubitemid 34756653)
15. Theodoratou E, Kyle J, Cetnarskyj R, Farrington SM, Tenesa A, Barnetson R and Porteous M, et al. Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2007, 16: 684-693. (Pubitemid 46650569)
16. Chen YC, Shen SC, Chow JM, Ko CH and Tseng SW. Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. Int J Oncol 2004, 25: 661-670
17. Neuhouser ML. Flavonoids and cancer prevention: What is the evidence in humans. Pharmaceutical Biol 2004, 42: 36-45. (Pubitemid 40103536)
18. Hodnick WF, Kung FS, Roetter WJ, Bohmont CW and Pardini RS. Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids a structure-Activity study. J Biochem Pharm 1986, 35: 2345-2357. (Pubitemid 16041954)
19. Murakami A, Ashida H and Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett 2008, 269: 315-325
20. Chowdhury R, Chowdhury S, Roychoudhury P, Mandal C and Chaudhuri K. Arsenic induced apoptosis in malignant melanoma cells is enhanced by menadione through ROS generation, p38 signaling and p53 activation. Apoptosis 2009, 14: 108-123
21. Zhao L, Chen Z, Wang J, YANG L, Zhao Q, Qi Q and Mu R, et al. Synergistic effect of 5-fluorouracil and the flavanoid oroxylin on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. Cancer Chemother Pharmacol 2010, 65: 481-489
22. Haddad AQ, Fleshner N, Nelson C, Saour B, Musquera M, Venkateswaran V and Klotz L. Antiproliferative mechanisms of the flavonoids 2, 2-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr Cancer 2010, 62: 668-681
23. Fang J, Nakamura H and Iyer AK. Tumor-Targeted induction of oxystress for cancer therapy. J Drug Target 2007, 15: 475-486. (Pubitemid 47213870)
24. Sharma A, Rajappa M, Saxena A and Sharma M. Antioxidant status in advanced cervical cancer patients undergoing neoadjuvant chemoradiation. Br J Biomed Sci 2007, 64: 23-27. (Pubitemid 46952968)
25. Batcioglu K, Mehmet N, Ozturk IC, Yilmaz M, Aydogdu N, Erguvan R and Uyumlu B, et al. Lipid peroxidation and antioxidant status in stomach cancer. Cancer Invest 2006, 24: 18-21. (Pubitemid 43247268)
26. Schwartz GK and Shah MA. Targeting the cell cycle: A new approach to cancer therapy. J Clin Oncol 2005, 23: 9408-9421
27. Haddad AQ, Venkateswaran V, Viswanathan L, Teahan SJ, Fleshner NE and Klotz LH. Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines. Prostate Cancer Prostatic Dis 2006, 9: 68-76. (Pubitemid 43378873)
28. Kuo HM, Chang LS, Lin YL, Lu HF, Yang JS, Lee JH and Chung JG. Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway. Anticancer Res 2007, 27: 395-405
29. Wang W, VanAlstyne PC, Irons KA, Chen S, Stewart JW and Birt DF. Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer 2004, 48: 106-114. (Pubitemid 38823552)
30. Yoshida M, Yamamoto M and Nikaido T. Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res 1992, 52: 6676-6681
31. Jaganathan SK and Mandal M. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. Invest New Drugs 2010, 28: 624-633
32. Takagaki N, Sowa Y, Oki T, Nakanishi R, Yogosawa S and Sakai T. Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway. Int J Oncol 2005, 26: 185-189