메뉴 건너뛰기




Volumn 16, Issue 1, 2015, Pages

Expression and cellular localization of hepcidin mRNA and protein in normal rat brain

Author keywords

Blood brain barrier; Brain iron homeostasis; Defensin; Ferroportin; Hepcidin; Inflammatory cytokines; Neurogenesis; Pericytes; Sub ventricular zone

Indexed keywords

HEPCIDIN; MESSENGER RNA; PROTEIN; HAMP PROTEIN, HUMAN; HAMP PROTEIN, RAT;

EID: 84928569217     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-015-0161-7     Document Type: Article
Times cited : (57)

References (42)
  • 1
    • 84857373097 scopus 로고    scopus 로고
    • Non-transferrin bound iron: a key role in iron overload and iron toxicity
    • Brissot P, Ropert M, Le Lan C, Loreal O. Non-transferrin bound iron: a key role in iron overload and iron toxicity. Biochim Biophys Acta. 2012;1820(3):403-10.
    • (2012) Biochim Biophys Acta , vol.1820 , Issue.3 , pp. 403-410
    • Brissot, P.1    Ropert, M.2    Lan, C.3    Loreal, O.4
  • 2
    • 77954249308 scopus 로고    scopus 로고
    • Two to tango: regulation of Mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Two to tango: regulation of Mammalian iron metabolism. Cell. 2010;142(1):24-38.
    • (2010) Cell , vol.142 , Issue.1 , pp. 24-38
    • Hentze, M.W.1    Muckenthaler, M.U.2    Galy, B.3    Camaschella, C.4
  • 3
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480(2-3):147-50.
    • (2000) FEBS Lett , vol.480 , Issue.2-3 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.J.3    Schulz, A.4    Forssmann, W.G.5    Schulz-Knappe, P.6
  • 4
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276(11):7806-10.
    • (2001) J Biol Chem , vol.276 , Issue.11 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 5
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276(11):7811-9.
    • (2001) J Biol Chem , vol.276 , Issue.11 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6
  • 6
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med. 2011;62:347-60.
    • (2011) Annu Rev Med , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 7
    • 84892657750 scopus 로고    scopus 로고
    • The liver: conductor of systemic iron balance
    • Meynard D, Babitt JL, Lin HY. The liver: conductor of systemic iron balance. Blood. 2014;123(2):168-76.
    • (2014) Blood , vol.123 , Issue.2 , pp. 168-176
    • Meynard, D.1    Babitt, J.L.2    Lin, H.Y.3
  • 8
    • 58149308295 scopus 로고    scopus 로고
    • Pro-hepcidin is unable to degrade the iron exporter ferroportin unless maturated by a furin-dependent process
    • Gagliardo B, Kubat N, Faye A, Jaouen M, Durel B, Deschemin JC, et al. Pro-hepcidin is unable to degrade the iron exporter ferroportin unless maturated by a furin-dependent process. J Hepatol. 2009;50(2):394-401.
    • (2009) J Hepatol , vol.50 , Issue.2 , pp. 394-401
    • Gagliardo, B.1    Kubat, N.2    Faye, A.3    Jaouen, M.4    Durel, B.5    Deschemin, J.C.6
  • 9
    • 4344600507 scopus 로고    scopus 로고
    • Hepcidin in iron metabolism
    • Ganz T. Hepcidin in iron metabolism. Curr Opin Hematol. 2004;11(4):251-4.
    • (2004) Curr Opin Hematol , vol.11 , Issue.4 , pp. 251-254
    • Ganz, T.1
  • 10
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-3.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 13
    • 84895755870 scopus 로고    scopus 로고
    • Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells
    • McCarthy RC, Kosman DJ. Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS One. 2014;9(2):e89003.
    • (2014) PLoS One , vol.9 , Issue.2
    • McCarthy, R.C.1    Kosman, D.J.2
  • 14
    • 79952673685 scopus 로고    scopus 로고
    • Identifying a window of vulnerability during fetal development in a maternal iron restriction model
    • Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, et al. Identifying a window of vulnerability during fetal development in a maternal iron restriction model. PLoS One. 2011;6(3):e17483.
    • (2011) PLoS One , vol.6 , Issue.3
    • Mihaila, C.1    Schramm, J.2    Strathmann, F.G.3    Lee, D.L.4    Gelein, R.M.5    Luebke, A.E.6
  • 15
    • 79953898190 scopus 로고    scopus 로고
    • Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity
    • Munoz P, Humeres A, Elgueta C, Kirkwood A, Hidalgo C, Nunez MT. Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity. J Biol Chem. 2011;286(15):13382-92.
    • (2011) J Biol Chem , vol.286 , Issue.15 , pp. 13382-13392
    • Munoz, P.1    Humeres, A.2    Elgueta, C.3    Kirkwood, A.4    Hidalgo, C.5    Nunez, M.T.6
  • 16
    • 77955508573 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment
    • Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology. 2010;139(2):393-408. 408 e391-392.
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 393-408
    • Pietrangelo, A.1
  • 17
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • Moos T, Morgan EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol. 2000;20(1):77-95.
    • (2000) Cell Mol Neurobiol , vol.20 , Issue.1 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 18
    • 73149083742 scopus 로고    scopus 로고
    • Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
    • Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology. 2009;50(6):1992-2000.
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1992-2000
    • Wallace, D.F.1    Summerville, L.2    Crampton, E.M.3    Frazer, D.M.4    Anderson, G.J.5    Subramaniam, V.N.6
  • 19
    • 84902194073 scopus 로고    scopus 로고
    • Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype
    • Zumerle S, Mathieu JR, Delga S, Heinis M, Viatte L, Vaulont S, et al. Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype. Blood. 2014;123(23):3646-50.
    • (2014) Blood , vol.123 , Issue.23 , pp. 3646-3650
    • Zumerle, S.1    Mathieu, J.R.2    Delga, S.3    Heinis, M.4    Viatte, L.5    Vaulont, S.6
  • 20
    • 33748569185 scopus 로고    scopus 로고
    • Distribution of the iron-regulating protein hepcidin in the murine central nervous system
    • Zechel S, Huber-Wittmer K, von Bohlen und O, Halbach O. Distribution of the iron-regulating protein hepcidin in the murine central nervous system. J Neurosci Res. 2006;84(4):790-800.
    • (2006) J Neurosci Res , vol.84 , Issue.4 , pp. 790-800
    • Zechel, S.1    Huber-Wittmer, K.2    Bohlen und, O.3    Halbach, O.4
  • 22
    • 47949130644 scopus 로고    scopus 로고
    • Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain
    • Wang Q, Du F, Qian ZM, Ge XH, Zhu L, Yung WH, et al. Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain. Endocrinology. 2008;149(8):3920-5.
    • (2008) Endocrinology , vol.149 , Issue.8 , pp. 3920-3925
    • Wang, Q.1    Du, F.2    Qian, Z.M.3    Ge, X.H.4    Zhu, L.5    Yung, W.H.6
  • 23
    • 21444448913 scopus 로고    scopus 로고
    • Catfish hepcidin gene is expressed in a wide range of tissues and exhibits tissue-specific upregulation after bacterial infection
    • Bao B, Peatman E, Li P, He C, Liu Z. Catfish hepcidin gene is expressed in a wide range of tissues and exhibits tissue-specific upregulation after bacterial infection. Dev Comp Immunol. 2005;29(11):939-50.
    • (2005) Dev Comp Immunol , vol.29 , Issue.11 , pp. 939-950
    • Bao, B.1    Peatman, E.2    Li, P.3    He, C.4    Liu, Z.5
  • 24
    • 34948830136 scopus 로고    scopus 로고
    • Identification and expression analysis of hepcidin-like cDNAs from pigeon (Columba livia)
    • Fu YM, Li SP, Wu YF, Chang YZ. Identification and expression analysis of hepcidin-like cDNAs from pigeon (Columba livia). Mol Cell Biochem. 2007;305(1-2):191-7.
    • (2007) Mol Cell Biochem , vol.305 , Issue.1-2 , pp. 191-197
    • Fu, Y.M.1    Li, S.P.2    Wu, Y.F.3    Chang, Y.Z.4
  • 25
    • 85005921759 scopus 로고    scopus 로고
    • The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease
    • Raha AA, Vaishnav RA, Friedland RP, Bomford A, Raha-Chowdhury R. The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. Acta Neuropathol Commun. 2013;1(1):55.
    • (2013) Acta Neuropathol Commun , vol.1 , Issue.1 , pp. 55
    • Raha, A.A.1    Vaishnav, R.A.2    Friedland, R.P.3    Bomford, A.4    Raha-Chowdhury, R.5
  • 26
    • 3242778563 scopus 로고    scopus 로고
    • Defensins: antimicrobial peptides of vertebrates
    • Ganz T. Defensins: antimicrobial peptides of vertebrates. C R Biol. 2004;327(6):539-49.
    • (2004) C R Biol , vol.327 , Issue.6 , pp. 539-549
    • Ganz, T.1
  • 27
    • 66649091212 scopus 로고    scopus 로고
    • Altered iron metabolism is part of the choroid plexus response to peripheral inflammation
    • Marques F, Falcao AM, Sousa JC, Coppola G, Geschwind D, Sousa N, et al. Altered iron metabolism is part of the choroid plexus response to peripheral inflammation. Endocrinology. 2009;150(6):2822-8.
    • (2009) Endocrinology , vol.150 , Issue.6 , pp. 2822-2828
    • Marques, F.1    Falcao, A.M.2    Sousa, J.C.3    Coppola, G.4    Geschwind, D.5    Sousa, N.6
  • 28
    • 80053030878 scopus 로고    scopus 로고
    • Hepcidin is involved in iron regulation in the ischemic brain
    • Ding H, Yan CZ, Shi H, Zhao YS, Chang SY, Yu P, et al. Hepcidin is involved in iron regulation in the ischemic brain. PLoS One. 2011;6(9):e25324.
    • (2011) PLoS One , vol.6 , Issue.9
    • Ding, H.1    Yan, C.Z.2    Shi, H.3    Zhao, Y.S.4    Chang, S.Y.5    Yu, P.6
  • 29
    • 84885121954 scopus 로고    scopus 로고
    • Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron
    • Lieblein-Boff JC, McKim DB, Shea DT, Wei P, Deng Z, Sawicki C, et al. Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron. J Neurosci. 2013;33(41):16334-45.
    • (2013) J Neurosci , vol.33 , Issue.41 , pp. 16334-16345
    • Lieblein-Boff, J.C.1    McKim, D.B.2    Shea, D.T.3    Wei, P.4    Deng, Z.5    Sawicki, C.6
  • 30
    • 84885953717 scopus 로고    scopus 로고
    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
    • Urrutia P, Aguirre P, Esparza A, Tapia V, Mena NP, Arredondo M, et al. Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. J Neurochem. 2013;126(4):541-9.
    • (2013) J Neurochem , vol.126 , Issue.4 , pp. 541-549
    • Urrutia, P.1    Aguirre, P.2    Esparza, A.3    Tapia, V.4    Mena, N.P.5    Arredondo, M.6
  • 31
    • 34248596015 scopus 로고    scopus 로고
    • Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain
    • Clardy SL, Wang X, Zhao W, Liu W, Chase GA, Beard JL, et al. Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain. J Neural Transm Suppl. 2006;71:173-96.
    • (2006) J Neural Transm Suppl , vol.71 , pp. 173-196
    • Clardy, S.L.1    Wang, X.2    Zhao, W.3    Liu, W.4    Chase, G.A.5    Beard, J.L.6
  • 32
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nat Neurosci. 2011;14(11):1398-405.
    • (2011) Nat Neurosci , vol.14 , Issue.11 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 33
    • 0034090265 scopus 로고    scopus 로고
    • Blood-brain barrier transport of 125I-labeled basic fibroblast growth factor
    • Deguchi Y, Naito T, Yuge T, Furukawa A, Yamada S, Pardridge WM, et al. Blood-brain barrier transport of 125I-labeled basic fibroblast growth factor. Pharm Res. 2000;17(1):63-9.
    • (2000) Pharm Res , vol.17 , Issue.1 , pp. 63-69
    • Deguchi, Y.1    Naito, T.2    Yuge, T.3    Furukawa, A.4    Yamada, S.5    Pardridge, W.M.6
  • 34
    • 0042232110 scopus 로고    scopus 로고
    • Studies on the internalization mechanism of cationic cell-penetrating peptides
    • Drin G, Cottin S, Blanc E, Rees AR, Temsamani J. Studies on the internalization mechanism of cationic cell-penetrating peptides. J Biol Chem. 2003;278(33):31192-201.
    • (2003) J Biol Chem , vol.278 , Issue.33 , pp. 31192-31201
    • Drin, G.1    Cottin, S.2    Blanc, E.3    Rees, A.R.4    Temsamani, J.5
  • 35
    • 0025295847 scopus 로고
    • Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins
    • Triguero D, Buciak J, Pardridge WM. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem. 1990;54(6):1882-8.
    • (1990) J Neurochem , vol.54 , Issue.6 , pp. 1882-1888
    • Triguero, D.1    Buciak, J.2    Pardridge, W.M.3
  • 36
    • 0023200855 scopus 로고
    • Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport
    • Kumagai AK, Eisenberg JB, Pardridge WM. Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport. J Biol Chem. 1987;262(31):15214-9.
    • (1987) J Biol Chem , vol.262 , Issue.31 , pp. 15214-15219
    • Kumagai, A.K.1    Eisenberg, J.B.2    Pardridge, W.M.3
  • 37
    • 0035833068 scopus 로고    scopus 로고
    • Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
    • Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol. 2001;435(4):406-17.
    • (2001) J Comp Neurol , vol.435 , Issue.4 , pp. 406-417
    • Cameron, H.A.1    McKay, R.D.2
  • 40
    • 67650450676 scopus 로고    scopus 로고
    • Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update
    • Lessmann V, Brigadski T. Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update. Neurosci Res. 2009;65(1):11-22.
    • (2009) Neurosci Res , vol.65 , Issue.1 , pp. 11-22
    • Lessmann, V.1    Brigadski, T.2
  • 41
    • 65549122626 scopus 로고    scopus 로고
    • Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice
    • Zhao JW, Raha-Chowdhury R, Fawcett JW, Watts C. Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice. Eur J Neurosci. 2009;29(9):1853-69.
    • (2009) Eur J Neurosci , vol.29 , Issue.9 , pp. 1853-1869
    • Zhao, J.W.1    Raha-Chowdhury, R.2    Fawcett, J.W.3    Watts, C.4
  • 42
    • 22744443932 scopus 로고    scopus 로고
    • CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease
    • Raha-Chowdhury R, Andrews SR, Gruen JR. CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. Brain Res Mol Brain Res. 2005;138(1):70-83.
    • (2005) Brain Res Mol Brain Res , vol.138 , Issue.1 , pp. 70-83
    • Raha-Chowdhury, R.1    Andrews, S.R.2    Gruen, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.