Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain

Journal of Neural Transmission, Supplement

Volumn , Issue 71, 2006, Pages 173-196

  Clardy, S L ^a   Wang, X ^a   Zhao, W ^a   Liu, W ^a   Chase, G A ^a   Beard, J L ^b   True Felt, B ^c   Connor, J R ^a,d  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN METABOLISM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; IRON DEFICIENCY; IRON METABOLISM; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; NEUROLOGICAL COMPLICATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; ANIMAL; ANIMAL BEHAVIOR; BRAIN; COMPARATIVE STUDY; DNA MICROARRAY; GENE EXPRESSION REGULATION; IRON INTAKE; MALE; METABOLISM; METHODOLOGY; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BRAIN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IRON; IRON, DIETARY; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34248596015     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-33328-0_19     Document Type: Article

References (108)

1. Aldred AR, Dickson PW, et al. (1987) Distribution of transferrin synthesis in brain and other tissues in the rat. J Biol Chem 262: 5293-5297
2. Anderson GW, Schoonover CM, et al. (2003) Control of thyroid hormone action in the developing rat brain. Thyroid 13: 1039-1056
3. Andrews NC (2000) Iron metabolism: iron deficiency and iron overload. Annu Rev Genomics Hum Genet 1: 75-98
4. Aniello F, Couchie D, et al. (1991) Regulation of five tubulin isotypes by thyroid hormone during brain development. J Neurochem 57: 1781-1786
5. Balazs R (1971) Biochemical effects of thyroid hormones in the developing brain. UCLA Forum Med Sci 14: 273-320
6. Balazs R, Brooksbank BW, et al. (1969) The effect of thyroid deficiency on myelination in the rat brain. J Physiol 201: 28-29
7. Bartlett WP, Li X-S, et al. (1991) Expression of transferrin mRNA in the CNS of normal and jimpy mice. J Neurochem 57: 318-322
8. Baud O, Fayol L, et al. (2003) Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. J Comp Neurol 465: 445-454
9. Beard J, Tobin B, et al. (1989) Evidence for thyroid hormone deficiency in iron-deficient anemic rats. J Nutr 119: 772-778
10. Beard JL, Connor JR (2003) Iron status and neural functioning. Annu Rev Nutr 23: 41-58
11. Beard JL, Hendricks MK, et al. (2005) Maternal iron deficiency anemia affects postpartum emotions and cognition. J Nutr 135: 267-272
12. Beard JL, Wiesinger JA, et al. (2003) Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats. Dev Neurosci 25: 308-315
13. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Statist Soc Series B: 289-300
14. Bolstad B, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185-193
15. Burhans MS, Dailey C, et al. (2005) Iron deficiency: differential effects on monoamine transporters. Nutr Neurosci 8: 31-38
16. Cheepsunthorn P, Radov L, et al. (2001) Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. GHa 35: 53-62
17. Chen Q, Connor JR, et al. (1995) Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats. J Nutr 125: 1529-1535
18. Cohen RI, Chandross KJ (2000) Fibroblast growth factor-9 modulates the expression of myelin related proteins and multiple fibroblast growth factor receptors in developing oligodendrocytes. J Neurosci Res 61: 273-287
19. Connor JR, Menzies SL, et al. (1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res 31: 75-83
20. Crowe A, Morgan EH (1992) Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res 592: 8-16
21. Dallman PR, Siimes MA, et al. (1975) Brain iron: persistent deficiency following short term iron deprivation in the young rat. Br J Heamatol 31: 209-215
22. de Deungria M, Rao R, et al. (2000) Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selected regions of neonatal rat brain. Pediatr Res 48: 169-176
23. Erikson K, Jones BC, Beard JL (2000) Dopamine reuptake is altered in iron deficiency anemia. J Nutr 130: 2831-2837
24. Erikson KM, Pinero DJ, et al. (1997) Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr 127: 2030-2038
25. Erikson KM, Syversen T, et al. (2004) Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency. J Nutr Biochem 15: 335-341
26. Espinosa de los Monteras A, Kumar S, et al. (1990) Transferrin gene expression and secretion by rat brain cells in vitro. J Neurosci Res 25: 576-580
27. Estivill-Torrus G, Pearson H, et al. (2002) Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development 129: 455-466
28. Faivre C, Legrand C, Rabie A (1984) In Purkinje cell dendrites of the young rat, thyroid hormone controls the resistance of microtubules to fixation at low temperature. Int J Dev Neurosci 2: 427-436
29. Felt BT, Lozoff B (1996) Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development. J Nutr 126: 693-701
30. Fernandez-Valle C, Gorman D, et al. (1997) Actin plays a role in both changes in cell shape and gene-expression associated with Schwann cell myelination. J Neurosci 17: 241-250
31. Fleming RE, Migas MC, et al. (2000) Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci USA 97: 2214-2219
32. Fortun J, Li J, et al. (2005) Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model. J Neurochem 92: 1531-1541
33. Galloway PG, Mulvihill P, et al. (1990) Immunochemical demonstration of tropomyosin in the neurofibrillary pathology of Alzheimer's disease. Am J Pathol 137: 291-300
34. Galloway PG, Perry G (1991) Tropomyosin distinguishes Lewy bodies of Parkinson disease from other neurofibrillary pathology. Brain Res 541: 347-349
35. Gao B, Hagenbuch B, et al. (2000) Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 294: 73-79
36. Gerlach M, Riederer P, et al. (1991) MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease. Eur J Pharmacol 208: 273-286
37. Han J, Day JR, et al. (2003) Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Nutr Neurosci 6: 1-10
38. Hediger MA, Romero MF, et al. (2004) The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins introduction. Pflugers Arch 447: 465-468
39. Holz A, Schaeren-Wiemers N, et al. (1996) Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. J Neurosci 16: 467-477
40. Irizarry R, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264
41. Jellinger K, Paulus W, et al. (1990) Brain iron and ferritin in Parkinson's and Alzheimer's diseases. J Neural Transm Park Dis Dement Sect 2: 327-340
42. Jones BC, Reed CL, et al. (2003) Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice. Nutr Neurosci 6: 369-377
43. Jorgenson LA, Wobken JD, et al. (2003) Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons. Dev Neurosci 25: 412-420
44. Kabashi E, Agar JN, et al. (2004) Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis. J Neurochem 89: 1325-1335
45. Kakunaga S, Ikeda W, et al. (2005) Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J Cell Sci 118: 1267-1277
46. Kakyo M, Sakagami H, et al. (1999) Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2). FEBS Lett 445: 343-346
47. Kaladhar M, Narasinga Rao BS (1982) Effects of iron deficiency on serotonin uptake in vitro by rat brain synaptic vesicles. J Neurochem 38: 1576-1581
48. Kalivendi SV, Kotamraju S, et al. (2003) 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. Biochem J 371: 151-164
49. Khanna S, Roy S, et al. (2003) Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem 278: 43508-43515
50. Kwak MK, Wakabayashi N, et al. (2003) Antioxidants enhance mammalian proteasome expression through the Keapl-Nrf2 signaling pathway. Mol Cell Biol 23: 8786-8794
51. Kwik-Uribe CL, Gietzen D, et al. (2000) Chronic marginal iron intakes during early development in mice result in persistent changes in dopamine metabolism and myelin composition. J Nutr 130: 2821-2830
52. Kwik-Uribe CL, Golub MS, et al. (2000) Chronic marginal iron intakes during early development in mice alter brain iron concentrations and behavior despite postnatal iron supplementation. J Nutr 130: 2040-2048
53. Larkin E, Rao GA (1990) Importance of fetal and neonatal iron: Adequacy for normal development of central nervouse system. Brain, Behavior and Iron in the Infant Diet. J. Dobbing. London, UK, Springer-Verlag: 43-63
54. LeVine SM, Goldman JE (1988) Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum. J Comp Neurol 277: 441-455
55. LeVine SM, Macklin WB (1990) Iron-enriched oligodendrocytes: a reexamination of their spatial distribution. J Neurosci Res 26: 508-512
56. Li C, Wong WH (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 98: 31-36
57. Li C, Wong WH (2003) DNA-Chip Analyzer (dChip) The analysis of gene expression data: methods and software. G. Parmigiani, Garrett, ES, Irizarry, R and Zeger, SL., Springer
58. Li N, Hartley DP, et al. (2002) Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. J Pharmacol Exp Ther 301: 551-560
59. Lotze MT, Tracey KJ (2005) High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5: 331-342
60. Lozoff B, Jimenez E, et al. (2000) Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 105: E51
61. MacInnis BL, Campenot RB (2005) Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway. Mol Cell Neurosci 28: 430-439
62. Matus A (2000) Actin-based plasticity in dendritic spines. Science 290: 754-758
63. Mizuno T, Yamashita T, et al. (2004) Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein. J Neurochem 91: 395-403
64. Moos T, Oates PS, et al. (1999) Iron-independent neuronal expression of transferrin receptor mRNA in the rat. Brain Res Mol Brain Res 72: 231-234
65. Morath DJ, Mayer-Proschel M (2002) Iron deficiency during embryogenesis and consequences for oligodendrocyte generation in vivo. Dev Neurosci 24: 197-207
66. Mortusewicz O, Schermelleh L, et al. (2005) Recruitment of DNA methyltransferase I to DNA repair sites. Proc Natl Acad Sci USA
67. Noe B, Hagenbuch B, et al. (1997) Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA 94: 10346-10350
68. Ortiz E, Pasquini JM, et al. (2004) Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J Neurosci Res 77: 681-689
69. Palti H, Meijer A, et al. (1985) Learning achievement and behavior at school of anemic and non-anemic infants. Early Hum Dev 10: 217-223
70. Pedraza L, Fidler L, et al. (1997) The active transport of myelin basic protein into the nucleus suggests a regulatory role in myelination. Neuron 18: 579-589
71. Perez EM, Hendricks MK, et al. (2005) Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. J Nutr 135: 850-855
72. Pham-Dinh D, Mattei MG, et al. (1993) Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Proc Natl Acad Sci USA 90: 7990-7994
73. Pinero DJ, Hu J, et al. (2000) Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains. Cell Mol Biol (Noisy-le-grand) 46: 761-776
74. Pinero DJ, Li NQ, et al. (2000) Variations in dietary iron alter brain iron metabolism in developing rats. J Nutr 130: 254-263
75. Rao R, de Ungria M, et al. (1999) Perinatal brain iron deficiency increases the vulnerability of rat hippocampus to hypoxic ischemic insult. J Nutr 129: 199-206
76. Rao R, Tkac I, et al. (2003) Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J Nutr 133: 3215-3221
77. Reichel C, Gao B, et al. (1999) Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 117: 688-695
78. Roskams AJ, Connor JR (1992) Transferrin receptor expression in myelin deficient (md) rats. J Neurosci Res 31: 421-427
79. Rosman NP, Malone MJ, et al. (1972) The effect of thyroid deficiency on myelination of brain. A morphological and biochemical study. Neurology 22: 99-106
80. Schaeren-Wiemers N, Bonnet A, et al. (2004) The raft-associated protein MAL is required for maintenance of proper axon-glia interactions in the central nervous system. J Cell Biol 166: 731-742
81. Schneider A, Montague P, et al. (1992) Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene. Nature 358: 758-761
82. Shah GN, Li J, et al. (1997) Cloning and characterization of a complementary DNA for a thyroid hormone-responsive protein in mature rat cerebral tissue. Biochem J 327: 617-623
83. Shang T, Kotamraju S, et al. (2004) 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. J Biol Chem 279: 19099-19112
84. Shiota C, Ikenaka K, et al. (1991) Developmental expression of myelin protein genes in dysmyelinating mutant mice: analysis by nuclear run-off transcription assay, in situ hybridization, and immunohistochemistry. J Neurochem 56: 818-826
85. Siddappa AJ, Rao RB, et al. (2003) Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain. Pediatr Res 53: 800-807
86. Stamm S, Casper D, et al. (1993) Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain. Proc Natl Acad Sci USA 90: 9857-9861
87. Steele-Perkins G, Plachez C, et al. (2005) The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol Cell Biol 25: 685-698
88. Takahashi H, Sekino Y, et al. (2003) Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. J Neurosci 23: 6586-6595
89. Taneja V, Mishra K, et al. (1986) Effect of early iron deficiency in rat on the gamma-aminobutyric acid shunt in brain. J Neurochem 46: 1670-1674
90. Tang YP, Ma YL, et al. (2001) mRNA differential display identification of thyroid hormone-responsive protein (THRP) gene in association with early phase of long-term potentiation. Hippocampus 11: 637-646
91. Thompson K, Menzies S, et al. (2003) Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J Neurosci Res 71: 46-63
92. Tsung A, Sahai R, et al. (2005) The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201: 1135-1143
93. Tukey J (1977) Exploratory Data Analysis. Reading, MA, Addison-Wesley
94. Tusher VG, Tibshirani R, et al. (2001) Significance analysts of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98: 5116-5121
95. Vannucci SJ, Simpson IA (2003) Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 285: E1127-E1134
96. Wang W, Stock RE, et al. (2004) A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression. J Biol Chem 279: 53491-53497
97. Weinberg J, Levine S, et al. (1979) Long-term consequences of early iron deficiency in the rat. Pharmacol Biochem Behav 11: 631-638
98. Xu ZQ, Zheng K, et al. (2005) Electrophysiological studies on galanin effects in brain - progress during the last six years. Neuropeptides 39: 267-273
99. Yao I, Hata Y, et al. (1999) MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein. J Biol Chem 274: 11889-11896
100. Youdim MB, Ben-Shachar D (1987) Minimal brain damage induced by early iron deficiency: modified dopaminergic neurotransmission. Isr J Med Sci 23: 19-25
101. Youdim MB, Ben-Shachar D, et al. (1989) Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am J Clin Nutr 50 [Suppl 3]: 607-615; discussion 615-617
102. Youdim MB, Yehuda S (2000) The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamine-opiate system. Cell Mol Biol (Noisy-le-grand) 46: 491-500
103. Youdim MB, Yehuda S, et al. (1981) Iron deficiency-induced circadian rhythm reversal of dopaminergic-mediated behaviours and thermoregulation in rats. Eur J Pharmacol 74: 295-301
104. Zambrzycka A, Kacprzak M (2003) Apolipoprotein E4 and A beta peptide 1-42 inhibit polyphosphoinositide biosynthesis in rat brain cortex. Pol J Pharmacol 55: 911-913
105. Zarghooni M, Soosaipillai A, et al. (2002) Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients. Clin Biochem 35: 225-231
106. Zhang EY, Knipp GT, et al. (2002) Structural biology and function of solute transporters: implications for identifying and designing substrates. Drug Metab Rev 34: 709-750
107. Zhang S, Grosse F (1994) Nuclear DNA helicase II unwinds both DNA and RNA. Biochemistry 33: 3906-3912
108. Zimmermann MB, Kohrle J (2002) The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid 12: 867-878