Neuroprotective impact of a vitamin trace element composition - A randomized, double blind, placebo controlled clinical trial with healthy volunteers

Neuroendocrinology Letters

Volumn 36, Issue 1, 2015, Pages 31-40

  Muss, Claus ^a,b   Mosgoeller, Wilhelm ^c   Endler, Thomas ^d  

^a Internationale Gesellschaft für angewandte Präventionsmedizin I GAP   (Austria)

^b St Elisabeth University   (Slovakia)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d Labor Endler   (Austria)

Author keywords

Blood brain barrier; Coenzym Q10 (Ubiquinone); Homocysteine; Lipidperoxidation; Mitochondrial dysfunction; Neurodegeneration; Superoxid dismutase activity; Vitamin B1; Vitamin B12 (Cobalamin); Vitamin B6 (Pyridoxin); Vitamin B9 (Folic acid); Vitamin E (Tocopherol)

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BIOTIN; CALCIUM; CARNITINE; CHROMIUM; COBALAMIN; COPPER; FOLIC ACID; HOMOCYSTEINE; IODINE; IRON; MAGNESIUM; MOLYBDENUM; OMEGA 3 FATTY ACID; PLACEBO; POTASSIUM; SELENIUM; SUPEROXIDE DISMUTASE; TOCOPHEROL; TRYPTOPHAN; UBIDECARENONE; VITAMIN; VITAMIN B GROUP; VITAMIN D; VITAMIN K GROUP; ZINC; CYANOCOBALAMIN; NEUROPROTECTIVE AGENT; PYRIDOXINE; TRACE ELEMENT;

ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NITROSATIVE STRESS; NORMAL HUMAN; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; ADULT; AGED; DRUG EFFECTS; METABOLISM; MIDDLE AGED;

ADULT; AGED; DOUBLE-BLIND METHOD; FEMALE; FOLIC ACID; HEALTHY VOLUNTEERS; HOMOCYSTEINE; HUMANS; LIPID PEROXIDATION; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; PYRIDOXINE; SUPEROXIDE DISMUTASE; TOCOPHEROLS; TRACE ELEMENTS; VITAMIN B 12; VITAMINS;

EID: 84928562253     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Aliev G, Priyadarshini M, Reddy VP, Grieg NH, Kaminsky Y, Cacabelos R, Ashraf GM, Jabir NR, et al. (2014). Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease. Current medicinal chemistry 21:2208-2217.
2. Anchisi L, Dessi S, Pani A, Mandas A (2012). Cholesterol homeostasis: a key to prevent or slow down neurodegeneration. Frontiers in physiology 3:486.
3. Baluchnejadmojarad T, Roghani M (2013). Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat. Journal of molecular neuroscience: MN 49:194-201.
4. Bhadri N, Sanji T, Madakasira Guggilla H, Razdan R (2013). Amelioration of behavioural, biochemical, and neurophysiological deficits by combination of monosodium glutamate with resveratrol/alpha-lipoic acid/coenzyme Q10 in rat model of cisplatininduced peripheral neuropathy. TheScientificWorldJournal 2013:565813.
5. Bjelakovic G, Nikolova D, Gluud C (2014). Antioxidant supplements and mortality. Current opinion in clinical nutrition and metabolic care 17:40-44.
6. Caldwell CC, Yao J, Brinton RD (2014). Targeting the Prodromal Stage of Alzheimer's Disease: Bioenergetic and Mitochondrial Opportunities. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics.
7. Choi SI, Ju WK, Choi EK, Kim J, Lea HZ, Carp Rl, Wisniewski HM, Kim YS (1998). Mitochondrial dysfunction induced by oxidative stress in the brains of hamsters infected with the 263 K scrapie agent. Acta neuropathologica 96:279-286.
8. Diaz-Rubio ME, Perez-Jimenez J, Martinez-Bartolome MA, Alvarez I, Saura-Calixto F (2014). Regular Consumption of an Antioxidant-rich Juice Improves Oxidative Status and Causes Metabolome Changes in Healthy Adults. Plant foods for human nutrition.
9. Enciu AM, Gherghiceanu M, Popescu BO (2013). Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration. Oxidative medicine and cellular longevity 2013:297512.
10. Gasparova Z, Janega P, Stara V, Ujhazy E (2012). Early and late stage of neurodegeneration induced by trimethyltin in hippocampus and cortex of male Wistar rats. Neuro endocrinology letters 33:689-696.
11. Gasparova Z, Stara V, Janega P, Navarova J, Sedlackova N, Mach M, Ujhazy E (2014). Pyridoindole antioxidant-induced preservation of rat hippocampal pyramidal cell number linked with reduction of oxidative stress yet without influence on cognitive deterioration in Alzheimer-like neurodegeneration. Neuro endocrinology letters 35:454-462.
12. Gil-Mohapel J, Brocardo PS, Christie BR (2014). The role of oxidative stress in Huntington's disease: are antioxidants good therapeutic candidates? Current drug targets 15:454-468.
13. Gilgun-Sherki Y, Melamed E, Often D (2003). Antioxidant treatment in Alzheimer's disease: current state. Journal of molecular neuroscience: MN 21:1-11.
14. Gonzalez-Escamilla G, Atienza M, Garcia-Solis D, Cantero JL (2014). Cerebral and blood correlates of reduced functional connectivity in mild cognitive impairment. Brain structure & function.
15. Guallar E, Stranges S, Mulrow C, Appel U, Miller ER, 3rd (2013). Enough is enough: Stop wasting money on vitamin and mineral supplements. Annals of internal medicine 159:850-851.
16. Haorah J, Rump TJ, Xiong H (2013). Reduction of brain mitochondrial beta-oxidation impairs complex I and V in chronic alcohol intake: the underlying mechanism for neurodegeneration. PloS one 8:e70833.
17. Herrmann W, Obeid R (2011). HCY: a biomarker in neurodegenerative diseases. Clinical chemistry and laboratory medicine: CCLM/FESCC 49:435-441.
18. Hohsfield LA, Humpe IC (2010). HCY enhances transmigration of rat monocytes through a brain capillary endothelial cell monolayer via ICAM-1. Current neurovascular research 7:192-200.
19. Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD (2006). Elevated levels of HCY compromise blood-brain barrier integrity in mice. Blood 107:591-593.
20. Kruman, Li, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP (2000). HCY elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. The Journal of neuroscience: the official journal of the Society for Neuroscience 20:6920-6926.
21. Kruman, Li, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, et al. (2002). Folic acid deficiency and HCY impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. The Journal of neuroscience: the official journal of the Society for Neuroscience 22:1752-1762.
22. Lee D, Shim MS, Kim KY, Noh YH, Kim H, Kim SY, Weinreb RN, Ju WK (2014). Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Investigative ophthalmology & visual science 55:993-1005.
23. Lehner C, Gehwolf R, Tempfer H, Krizbai I, Hennig B, Bauer HC, Bauer H (2011). Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases. Antioxidants & redox signaling 15:1305-1323.
24. Lopez-Erauskin J, Fourcade S, Galino J, Ruiz M, Schluter A, Naudi A, Jove M, Portero-Otin M, et al. (2011). Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. Annals of neurology 70:84-92.
25. Maler JM, Seifert W, Huther G, Wiltfang J, Ruther E, Kornhuber J, Bleich S (2003). HCY induces cell death of rat astrocytes in vitro. Neuroscience letters 347:85-88.
26. Mancuso C, Barone E, Guido P, Miceli F, Di Domenico F, Perluigi M, Santangelo R, Preziosi P (2012). Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro. Neuroscience letters 518:101-105.
27. Marin T, Contreras P, Castro JF, Chamorro D, Balboa E, Bosch-Morato M, Munoz FJ, Alvarez AR, et al. (2014). Vitamin E dietary supplementation improves neurological symptoms and decreases c-Abl/p73 activation in Niemann-Pick C mice. Nutrients 6:3000-3017.
28. Mattson MP, Kruman, Li, Duan W (2002). Folic acid and HCY in age-related disease. Ageing research reviews 1:95-111.
29. Muthukumaran K, Leahy S, Harrison K, Sikorska M, Sandhu JK, Cohen J, Keshan C, Lopatin D, et al. (2014). Orally delivered water soluble Coenzyme Q10 (Ubisol-QIO) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson's disease. BMC neuroscience 15:21.
30. Shen L, Ji HF (2012). Vitamin E: supplement versus diet in neurodegenerative diseases. Trends in molecular medicine 18:443-445.
31. Wang P, Xie K, Wang C, Bi J (2014). Oxidative stress induced by lipid peroxidation is related with inflammation of demyelination and neurodegeneration in multiple sclerosis. European neurology 72:249-254.
32. Zhang XM, Huang GW, Tian ZH, Ren DL, JXW (2009). Folate deficiency induces neural stem cell apoptosis by increasing HCY in vitro. Journal of clinical biochemistry and nutrition 45:14-19.