메뉴 건너뛰기




Volumn 49, Issue 3, 2011, Pages 435-441

Homocysteine: A biomarker in neurodegenerative diseases

Author keywords

Alzheimer's disease; cognitive impairment; dementia; folate; homocysteine; stroke; vitamin B12; vitamin deficiency

Indexed keywords

BIOLOGICAL MARKER; HOMOCYSTEINE; VITAMIN B GROUP;

EID: 79952783461     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.084     Document Type: Review
Times cited : (125)

References (74)
  • 1
    • 33646747001 scopus 로고    scopus 로고
    • Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
    • DOI 10.1016/j.febslet.2006.04.088, PII S001457930600545X
    • Obeid R, Herrmann W. Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 2006;580:2994-3005. (Pubitemid 43744523)
    • (2006) FEBS Letters , vol.580 , Issue.13 , pp. 2994-3005
    • Obeid, R.1    Herrmann, W.2
  • 2
    • 33746310315 scopus 로고    scopus 로고
    • Alzheimer's disease
    • DOI 10.1016/S0140-6736(06)69113-7, PII S0140673606691137
    • Blennow K, de Leon MJ, Zetterberg H. Alzheimer's disease. Lancet 2006;368:387-403. (Pubitemid 44108123)
    • (2006) Lancet , vol.368 , Issue.9533 , pp. 387-403
    • Blennow, K.1    De Leon, M.J.2    Zetterberg, H.3
  • 3
    • 0026823074 scopus 로고
    • Immunohistochemical evidence of oxidative wcorrectedx stress in Alzheimer's disease
    • Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative wcorrectedx stress in Alzheimer's disease. Am J Pathol 1992;140:621-8.
    • (1992) Am J Pathol , vol.140 , pp. 621-628
    • Pappolla, M.A.1    Omar, R.A.2    Kim, K.S.3    Robakis, N.K.4
  • 4
    • 0030898724 scopus 로고    scopus 로고
    • An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease
    • Lyras L, Cairns NJ, Jenner A, Jenner P, Halliwell B. An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J Neurochem 1997;68: 2061-9. (Pubitemid 27176143)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.5 , pp. 2061-2069
    • Lyras, L.1    Cairns, N.J.2    Jenner, A.3    Jenner, P.4    Halliwell, B.5
  • 5
    • 0026646605 scopus 로고
    • Isolation and quantification of soluble Alzheimer's betapeptide from biological fluids
    • Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, et al. Isolation and quantification of soluble Alzheimer's betapeptide from biological fluids. Nature 1992;359:325-7.
    • (1992) Nature , vol.359 , pp. 325-327
    • Seubert, P.1    Vigo-Pelfrey, C.2    Esch, F.3    Lee, M.4    Dovey, H.5    Davis, D.6
  • 6
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 2002;297:353-6. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 8
    • 77957742136 scopus 로고    scopus 로고
    • Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairment
    • Johnson JK, Pa J, Boxer AL, Kramer JH, Freeman K, Yaffe K. Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairment. Dement Geriatr Cogn Disord 2010;30:344-51.
    • (2010) Dement Geriatr Cogn Disord , vol.30 , pp. 344-351
    • Johnson, J.K.1    Pa, J.2    Boxer, A.L.3    Kramer, J.H.4    Freeman, K.5    Yaffe, K.6
  • 9
    • 1842528072 scopus 로고    scopus 로고
    • Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology
    • Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA. Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 2004;62:1148-55. (Pubitemid 38456510)
    • (2004) Neurology , vol.62 , Issue.7 , pp. 1148-1155
    • Schneider, J.A.1    Wilson, R.S.2    Bienias, J.L.3    Evans, D.A.4    Bennett, D.A.5
  • 10
    • 33646696167 scopus 로고    scopus 로고
    • Reducing the risk of dementia: Efficacy of long-term treatment of hypertension
    • DOI 10.1161/01.STR.0000217653.01615.93, PII 0000767020060500000017
    • Peila R, White LR, Masaki K, Petrovitch H, Launer LJ. Reducing the risk of dementia: Efficacy of long-term treatment of hypertension. Stroke 2006;37:1165-70. (Pubitemid 43731856)
    • (2006) Stroke , vol.37 , Issue.5 , pp. 1165-1170
    • Peila, R.1    White, L.R.2    Masaki, K.3    Petrovitch, H.4    Launer, L.J.5
  • 12
    • 33846102164 scopus 로고    scopus 로고
    • Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200. (Pubitemid 46067634)
    • (2007) American Journal of Clinical Nutrition , vol.85 , Issue.1 , pp. 193-200
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 14
    • 36448952023 scopus 로고    scopus 로고
    • Chronic kidney disease is associated with white matter hyperintensity volume: The Northern Manhattan Study (NOMAS)
    • DOI 10.1161/STROKEAHA.107.493593, PII 0000767020071200000003
    • Khatri M, Wright CB, Nickolas TL, Yoshita M, Paik MC, Kranwinkel G, et al. Chronic kidney disease is associated with white matter hyperintensity volume: The Northern Manhattan Study (NOMAS). Stroke 2007;38:3121-6. (Pubitemid 350175724)
    • (2007) Stroke , vol.38 , Issue.12 , pp. 3121-3126
    • Khatri, M.1    Wright, C.B.2    Nickolas, T.L.3    Yoshita, M.4    Paik, M.C.5    Kranwinkel, G.6    Sacco, R.L.7    Decarli, C.8
  • 17
    • 78649422312 scopus 로고    scopus 로고
    • Functional expressions of the aging brain
    • Folstein M, Folstein S. Functional expressions of the aging brain. Nutr Rev 2010;68(Suppl 2):S70-3.
    • (2010) Nutr Rev , vol.68 , Issue.SUPPL. 2
    • Folstein, M.1    Folstein, S.2
  • 18
    • 43549091613 scopus 로고    scopus 로고
    • Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    • DOI 10.1001/archneur.65.5.642
    • Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, et al. Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol 2008;65:642-9. (Pubitemid 351679660)
    • (2008) Archives of Neurology , vol.65 , Issue.5 , pp. 642-649
    • Seshadri, S.1    Wolf, P.A.2    Beiser, A.S.3    Selhub, J.4    Au, R.5    Jacques, P.F.6    Yoshita, M.7    Rosenberg, I.H.8    D'Agostino, R.B.9    DeCarli, C.10
  • 19
    • 77958567930 scopus 로고    scopus 로고
    • Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial
    • Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial. PLoS ONE 2010;5: E12244.
    • (2010) PLoS ONE , vol.5
    • Smith, A.D.1    Smith, S.M.2    De Jager, C.A.3    Whitbread, P.4    Johnston, C.5    Agacinski, G.6
  • 20
    • 34247328566 scopus 로고    scopus 로고
    • Plasma homocysteine is elevated in elderly patients with memory complaints and vascular disease
    • DOI 10.1159/000100927
    • Nilsson K, Gustafson L, Hultberg B. Plasma homocysteine is elevated in elderly patients with memory complaints and vascular disease. Dement Geriatr Cogn Disord 2007;23:321-6. (Pubitemid 46631939)
    • (2007) Dementia and Geriatric Cognitive Disorders , vol.23 , Issue.5 , pp. 321-326
    • Nilsson, K.1    Gustafson, L.2    Hultberg, B.3
  • 21
    • 1342310863 scopus 로고    scopus 로고
    • 12 Status in the Elderly as Judged by Available Biochemical Markers
    • DOI 10.1373/clinchem.2003.021717
    • Obeid R, Schorr H, Eckert R, Herrmann W. Vitamin B12 status in the elderly as judged by available biochemical markers. Clin Chem 2004;50:238-41. (Pubitemid 38125734)
    • (2004) Clinical Chemistry , vol.50 , Issue.1 , pp. 238-241
    • Obeid, R.1    Schorr, H.2    Eckert, R.3    Herrmann, W.4
  • 24
    • 48249125816 scopus 로고    scopus 로고
    • Causes of vitamin B12 and folate deficiency
    • Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull 2008;29:S20-34.
    • (2008) Food Nutr Bull , vol.29
    • Allen, L.H.1
  • 25
    • 77953929752 scopus 로고    scopus 로고
    • Long-term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: Randomised placebo controlled trial
    • de JJ, Kooy A, Lehert P, Wulffele MG, van der KJ, Bets D, et al. Long-term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: Randomised placebo controlled trial. Br Med J 2010;340:c2181.
    • (2010) Br Med J , vol.340
    • De, J.J.1    Kooy, A.2    Lehert, P.3    Wulffele, M.G.4    Van Der, K.J.5    Bets, D.6
  • 27
    • 33845496742 scopus 로고    scopus 로고
    • Methylmalonic acid and cognitive function in the medical research council cognitive function and ageing study
    • McCracken C, Hudson P, Ellis R, McCaddon A. Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study. Am J Clin Nutr 2006; 84:1406-11. (Pubitemid 44912825)
    • (2006) American Journal of Clinical Nutrition , vol.84 , Issue.6 , pp. 1406-1411
    • McCracken, C.1    Hudson, P.2    Ellis, R.3    McCaddon, A.4
  • 28
    • 3242784006 scopus 로고    scopus 로고
    • Total homocysteine and cognition in a tri-ethnic cohort: The Northern Manhattan Study
    • Wright CB, Lee HS, Paik MC, Stabler SP, Allen RH, Sacco RL. Total homocysteine and cognition in a tri-ethnic cohort: The Northern Manhattan Study. Neurology 2004;63:254-60. (Pubitemid 38971123)
    • (2004) Neurology , vol.63 , Issue.2 , pp. 254-260
    • Wright, C.B.1    Lee, H.-S.2    Paik, M.C.3    Stabler, S.P.4    Allen, R.H.5    Sacco, R.L.6
  • 30
    • 33846021288 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia: A critical review of old and new aspects
    • DOI 10.2174/138920007779315008
    • Herrmann W, Herrmann M, Obeid R. Hyperhomocysteinaemia: A critical review of old and new aspects. Curr Drug Metab 2007;8:17-31. (Pubitemid 46043889)
    • (2007) Current Drug Metabolism , vol.8 , Issue.1 , pp. 17-31
    • Herrmann, W.1    Herrmann, M.2    Obeid, R.3
  • 32
    • 0036892748 scopus 로고    scopus 로고
    • Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage
    • DOI 10.1002/jnr.10416
    • Ho PI, Ortiz D, Rogers E, Shea TB. Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res 2002;70:694-702. (Pubitemid 35397143)
    • (2002) Journal of Neuroscience Research , vol.70 , Issue.5 , pp. 694-702
    • Ho, P.I.1    Ortiz, D.2    Rogers, E.3    Shea, T.B.4
  • 33
    • 0342437533 scopus 로고    scopus 로고
    • Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils
    • DOI 10.1016/S0169-328X(96)00245-8, PII S0169328X96002458
    • Rao AM, Baskaya MK, Maley ME, Kindy MS, Dempsey RJ. Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils. Brain Res Mol Brain Res 1997;44:134-8. (Pubitemid 27050869)
    • (1997) Molecular Brain Research , vol.44 , Issue.1 , pp. 134-138
    • Rao, A.M.1    Baskaya, M.K.2    Maley, M.E.3    Kindy, M.S.4    Dempsey, R.J.5
  • 34
    • 0021076323 scopus 로고
    • The effect of S-adenosyl-L-methionine on ischemia-induced disturbances of brain phospholipid in the gerbil
    • DOI 10.1007/BF00964161
    • Trovarelli G, De Medio GE, Porcellati S, Stramentinoli G, Porcellati G. The effect of S-adenosyl-L-methionine on ischemiainduced disturbances of brain phospholipid in the gerbil. Neurochem Res 1983;8:1597-609. (Pubitemid 14157631)
    • (1983) Neurochemical Research , vol.8 , Issue.12 , pp. 1597-1609
    • Trovarelli, G.1    De Medio, G.E.2    Porcellati, S.3
  • 35
    • 0025606597 scopus 로고
    • Cerebrospinal fluid S-adenosylmethionine in depression and dementia: Effects of treatment with parenteral and oral S-adenosylmethionine
    • Bottiglieri T, Godfrey P, Flynn T, Carney MW, Toone BK, Reynolds EH. Cerebrospinal fluid S-adenosylmethionine in depression and dementia: Effects of treatment with parenteral and oral S-adenosylmethionine. J Neurol Neurosurg Psychiatry 1990;53:1096-8.
    • (1990) J Neurol Neurosurg Psychiatry , vol.53 , pp. 1096-1098
    • Bottiglieri, T.1    Godfrey, P.2    Flynn, T.3    Carney, M.W.4    Toone, B.K.5    Reynolds, E.H.6
  • 42
    • 13444260835 scopus 로고    scopus 로고
    • 12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur studies of successful aging
    • DOI 10.1016/j.amjmed.2004.08.019
    • Kado DM, Karlamangla AS, Huang MH, Troen A, Rowe JW, Selhub J, et al. Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 2005;118:161-7. (Pubitemid 40202865)
    • (2005) American Journal of Medicine , vol.118 , Issue.2 , pp. 161-167
    • Kado, D.M.1    Karlamangla, A.S.2    Huang, M.-H.3    Troen, A.4    Rowe, J.W.5    Selhub, J.6    Seeman, T.E.7
  • 43
    • 0037309445 scopus 로고    scopus 로고
    • Homocysteine, white matter hyperintensities, and cognition in healthy elderly people
    • DOI 10.1002/ana.10440
    • Dufouil C, Alperovitch A, Ducros V, Tzourio C. Homocysteine, white matter hyperintensities, and cognition in healthy elderly people. Ann Neurol 2003;53:214-21. (Pubitemid 36164003)
    • (2003) Annals of Neurology , vol.53 , Issue.2 , pp. 214-221
    • Dufouil, C.1    Alperovitch, A.2    Ducros, V.3    Tzourio, C.4
  • 44
    • 66749189122 scopus 로고    scopus 로고
    • Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: A prospective study
    • Kivipelto M, Annerbo S, Hultdin J, Backman L, Viitanen M, Fratiglioni L, et al. Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: A prospective study. Eur J Neurol 2009;16:808-13.
    • (2009) Eur J Neurol , vol.16 , pp. 808-813
    • Kivipelto, M.1    Annerbo, S.2    Hultdin, J.3    Backman, L.4    Viitanen, M.5    Fratiglioni, L.6
  • 45
    • 78049519410 scopus 로고    scopus 로고
    • Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study
    • Hooshmand B, Solomon A, Kareholt I, Leiviska J, Rusanen M, Ahtiluoto S, et al. Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study. Neurology 2010;75:1408-14.
    • (2010) Neurology , vol.75 , pp. 1408-1414
    • Hooshmand, B.1    Solomon, A.2    Kareholt, I.3    Leiviska, J.4    Rusanen, M.5    Ahtiluoto, S.6
  • 48
    • 48249091668 scopus 로고    scopus 로고
    • The worldwide challenge of the dementias: A role for B vitamins and homocysteine?
    • Smith AD. The worldwide challenge of the dementias: A role for B vitamins and homocysteine? Food Nutr Bull 2008;29: S143-72.
    • (2008) Food Nutr Bull , vol.29
    • Smith, A.D.1
  • 51
    • 36849077234 scopus 로고    scopus 로고
    • The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases
    • DOI 10.1515/CCLM.2007.356
    • Obeid R, McCaddon A, Herrmann W. The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and neuropsychiatric diseases. Clin Chem Lab Med 2007;45:1590-606. (Pubitemid 350232981)
    • (2007) Clinical Chemistry and Laboratory Medicine , vol.45 , Issue.12 , pp. 1590-1606
    • Obeid, R.1    McCaddon, A.2    Herrmann, W.3
  • 52
    • 0036094732 scopus 로고    scopus 로고
    • Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease
    • Hogervorst E, Ribeiro HM, Molyneux A, Budge M, Smith AD. Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease. Arch Neurol 2002;59:787-93. (Pubitemid 34517761)
    • (2002) Archives of Neurology , vol.59 , Issue.5 , pp. 787-793
    • Hogervorst, E.1    Ribeiro, H.M.2    Molyneux, A.3    Budge, M.4    David Smith, A.5
  • 56
    • 17444438459 scopus 로고    scopus 로고
    • Homocysteine in cerebral macroangiography and microangiopathy
    • DOI 10.1016/S0140-6736(99)00309-8
    • Fassbender K, Mielke O, Bertsch T, Nafe B, Froschen S, Hennerici M. Homocysteine in cerebral macroangiography and microangiopathy. Lancet 1999;353:1586-7. (Pubitemid 29219212)
    • (1999) Lancet , vol.353 , Issue.9164 , pp. 1586-1587
    • Fassbender, K.1    Mielke, O.2    Bertsch, T.3    Nafe, B.4    Froschen, S.5    Hennerici, M.6
  • 60
    • 65249094749 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy and stroke risk, severity, and disability. Additional findings from the HOPE 2 trial
    • Saposnik G, Ray JG, Sheridan P, McQueen M, Lonn E. Homocysteine- lowering therapy and stroke risk, severity, and disability. Additional findings from the HOPE 2 trial. Stroke 2009; 40:1365-72.
    • (2009) Stroke , vol.40 , pp. 1365-1372
    • Saposnik, G.1    Ray, J.G.2    Sheridan, P.3    McQueen, M.4    Lonn, E.5
  • 61
    • 77957949167 scopus 로고    scopus 로고
    • Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37,485 individuals
    • Clarke R, Halsey J, Lewington S, Lonn E, Armitage J, Manson JE, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37,485 individuals. Arch Intern Med 2010;170:1622-31.
    • (2010) Arch Intern Med , vol.170 , pp. 1622-1631
    • Clarke, R.1    Halsey, J.2    Lewington, S.3    Lonn, E.4    Armitage, J.5    Manson, J.E.6
  • 62
    • 34249730020 scopus 로고    scopus 로고
    • Efficacy of folic acid supplementation in stroke prevention: A meta-analysis
    • DOI 10.1016/S0140-6736(07)60854-X, PII S014067360760854X
    • Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, et al. Efficacy of folic acid supplementation in stroke prevention: A metaanalysis. Lancet 2007;369:1876-82. (Pubitemid 46829358)
    • (2007) Lancet , vol.369 , Issue.9576 , pp. 1876-1882
    • Wang, X.1    Qin, X.2    Demirtas, H.3    Li, J.4    Mao, G.5    Huo, Y.6    Sun, N.7    Liu, L.8    Xu, X.9
  • 63
    • 77953133802 scopus 로고    scopus 로고
    • Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: A meta-analysis
    • Lee M, Hong KS, Chang SC, Saver JL. Efficacy of homocysteine- lowering therapy with folic acid in stroke prevention: A meta-analysis. Stroke 2010;41:1205-12.
    • (2010) Stroke , vol.41 , pp. 1205-1212
    • Lee, M.1    Hong, K.S.2    Chang, S.C.3    Saver, J.L.4
  • 64
    • 33645743547 scopus 로고    scopus 로고
    • Improvement in stroke mortality in Canada and the United States, 1990 to 2002
    • DOI 10.1161/CIRCULATIONAHA.105.570846, PII 0000301720060314000011
    • Yang Q, Botto LD, Erickson JD, Berry RJ, Sambell C, Johansen H, et al. Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation 2006;113:1335-43. (Pubitemid 43739455)
    • (2006) Circulation , vol.113 , Issue.10 , pp. 1335-1343
    • Yang, Q.1    Botto, L.D.2    Erickson, J.D.3    Berry, R.J.4    Sambell, C.5    Johansen, H.6    Friedman, J.M.7
  • 65
    • 27744532252 scopus 로고    scopus 로고
    • Improvement in stroke and ischemic heart disease mortality in the United States 1990-2001
    • Yang Q, Friedmann JM, Botto LD. Improvement in stroke and ischemic heart disease mortality in the United States 1990- 2001. Clin Chem Lab Med 2005;43:A14.
    • (2005) Clin Chem Lab Med , vol.43
    • Yang, Q.1    Friedmann, J.M.2    Botto, L.D.3
  • 66
    • 59649085600 scopus 로고    scopus 로고
    • Plasma Abeta, homocysteine, and cognition: The vitamin intervention for stroke prevention (VISP) trial
    • Viswanathan A, Raj S, Greenberg SM, Stampfer M, Campbell S, Hyman BT, et al. Plasma Abeta, homocysteine, and cognition: The Vitamin Intervention for Stroke Prevention (VISP) trial. Neurology 2009;72:268-72.
    • (2009) Neurology , vol.72 , pp. 268-272
    • Viswanathan, A.1    Raj, S.2    Greenberg, S.M.3    Stampfer, M.4    Campbell, S.5    Hyman, B.T.6
  • 69
    • 78149472628 scopus 로고    scopus 로고
    • B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial
    • Almeida OP, Marsh K, Alfonso H, Flicker L, Davis TM, Hankey GJ. B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial. Ann Neurol 2010;68: 503-10.
    • (2010) Ann Neurol , vol.68 , pp. 503-510
    • Almeida, O.P.1    Marsh, K.2    Alfonso, H.3    Flicker, L.4    Davis, T.M.5    Hankey, G.J.6
  • 70
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • DOI 10.1016/S0166-2236(03)00032-8
    • Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003;26:137-46. (Pubitemid 36183675)
    • (2003) Trends in Neurosciences , vol.26 , Issue.3 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 71
    • 77149130504 scopus 로고    scopus 로고
    • B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A
    • Nicolia V, Fuso A, Cavallaro RA, Di LA, Scarpa S. B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A. J Alzheimers Dis 2010;19:895-907.
    • (2010) J Alzheimers Dis , vol.19 , pp. 895-907
    • Nicolia, V.1    Fuso, A.2    Cavallaro, R.A.3    Di, L.A.4    Scarpa, S.5
  • 73
    • 59049103180 scopus 로고    scopus 로고
    • Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood of rats: Protective effect of folic acid
    • Matte C, Mackedanz V, Stefanello FM, Scherer EB, Andreazza AC, Zanotto C, et al. Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood of rats: Protective effect of folic acid. Neurochem Int 2009;54:7-13.
    • (2009) Neurochem Int , vol.54 , pp. 7-13
    • Matte, C.1    Mackedanz, V.2    Stefanello, F.M.3    Scherer, E.B.4    Andreazza, A.C.5    Zanotto, C.6
  • 74
    • 67349202867 scopus 로고    scopus 로고
    • Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study
    • Stanojlovic O, Rasic-Markovic A, Hrncic D, Susic V, Macut D, Radosavljevic T, et al. Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study. Cell Mol Neurobiol 2009;29:329-39.
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 329-339
    • Stanojlovic, O.1    Rasic-Markovic, A.2    Hrncic, D.3    Susic, V.4    Macut, D.5    Radosavljevic, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.