Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 24, 2008, Pages 12059-12063

  Cao, Jun ^a   Liu, Yong ^b   Jia, Li ^a   Jiang, Li Ping ^a   Geng, Cheng Yan ^a   Yao, Xiao Feng ^a   Kong, Ying ^a   Jiang, Bao Na ^a   Zhong, Lai Fu ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Acrylamide; Antigenotoxicity; Antioxidant; Curcumin; Cytotoxicity; HepG2 cells

Indexed keywords

CURCUMA LONGA; RODENTIA;

ACRYLAMIDE; CURCUMIN; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ARTICLE; CELL SURVIVAL; CHEMISTRY; COMET ASSAY; CURCUMA LONGA; DNA DAMAGE; DNA FRAGMENTATION; DRUG EFFECT; HUMAN; METABOLISM; TUMOR CELL LINE;

ACRYLAMIDE; CELL LINE, TUMOR; CELL SURVIVAL; COMET ASSAY; CURCUMA; CURCUMIN; DNA DAMAGE; DNA FRAGMENTATION; FREE RADICAL SCAVENGERS; HUMANS; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

EID: 58849166247     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf8026827     Document Type: Article

References (34)

1. Tareke, E.; Rydberg, P.; Karlsson, P.; Eriksson, S.; Tornqvist, M. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J. Agric. Food Chem. 2002, 50 (17), 4998-5006.
2. James, E. K. Acrylamide Carcinogenicity. J. Agric. Food Chem. 2008, 56 (15), 5984-5988.
3. Dearfield, K. L.; Douglas, G. R.; Ehling, U. H.; Moore, M. M.; Sega, G. A.; Brusick, D. J. Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mutat. Res. 1995, 330 (1-2), 71-99.
4. Tsuda, H.; Shimizu, C. S.; Taketomi, M. K.; Hasegawa, M. M.; Hamada, A.; Kawata, K. M.; Inui, N. Acrylamide; induction of DNA damage, chromosomal aberrations and cell transformation without gene mutations. Mutagenesis 1993, 8 (1), 23-29.
5. Baum, M.; Fauth, E.; Fritzen, S.; Herrmann, A.; Mertes, P.; Merz, K.; Rudolphi, M.; Zankl, H.; Eisenbrand, G. Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood. Mutat. Res. 2005, 580 (1-2), 61-69.
6. Koyama, N.; Sakamoto, H.; Sakuraba, M.; Koizumi, T.; Takashima, Y.; Hayashi, M.; Matsufuji, H.; Yamagata, K.; Masuda, S.; Kinae, N.; Honma, M. Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells. Mutat. Res. 2006, 603 (2), 151-158.
7. Mersch-Sundermann, V.; Knasmuller, S.; Wu, X. J.; Darroudi, F.; Kassie, F. Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 2004, 198 (1-3), 329-340.
8. Jiang, L.; Cao, J.; An, Y.; Geng, C.; Qu, S.; Jiang, L.; Zhong, L. Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cells. Toxicol. In Vitro 2007, 21 (8), 1486-1492.
9. Chan, W. H.; Wu, H. J.; Hsuuw, Y. D. Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cells. Ann. N.Y. Acad. Sci. 2005, 1042, 372-378.
10. Sreejayan; Rao, M. N. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol. 1994, 46 (12), 1013-1016.
11. Polasa, K.; Naidu, A. N.; Ravindranath, I.; Krishnaswamy, K. Inhibition of B(a)P induced strand breaks in presence of curcumin. Mutat. Res. 2004, 557 (2), 203-213.
12. Abraham, S. K.; Sarma, L.; Kesavan, P. C. Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage. Mutat. Res. 1993, 303 (3), 109-112.
13. Antunes, L. M.; Araujo, M. C.; Darin, J. D.; Bianchi, M. L. Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis in Wistar rat bone marrow cells. Mutat. Res. 2000, 465 (1-2), 131-137.
14. Anto, R. J.; George, J.; Babu, K. V.; Rajasekharan, K. N.; Kuttan, R. Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. Mutat. Res. 1996, 370 (2), 127-131.
15. Cao, J.; Jia, L.; Zhou, H. M.; Liu, Y.; Zhong, L. F. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol. Sci. 2006, 91 (2), 476-483.
16. Cao, J.; Jiang, L. P.; Liu, Y.; Yang, G.; Yao, X. F.; Zhong, L. F. Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells. Toxicon 2007, 49 (8), 1219-1222.
17. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65 (1-2), 55-63.
18. Sohn, J. H.; Han, K. L.; Lee, S. H.; Hwang, J. K. Protective effects of panduratin A against oxidative damage of tert-butylhydroperoxide in human HepG2 cells. Biol. Pharm. Bull. 2005, 28 (6), 1083-1086.
19. Miyajima, A.; Nakashima, J.; Yoshioka, K.; Tachibana, M.; Tazaki, H.; Murai, M. Role of reactive oxygen species in cis-dichlorodiammineplatinum- induced cytotoxicity on bladder cancer cells. Br. J. Cancer 1997, 76 (2), 206-210.
20. Singh, N. P.; Stephens, R. E. Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching. Mutat. Res. 1997, 383 (2), 167-175.
21. Uhl, M.; Helma, C.; Knasmuller, S. Evaluation of the single cell gel electrophoresis assay with human hepatoma (Hep G2) cells. Mutat. Res. 2000, 468 (2), 213-225.
22. Gupta, D.; Crosby, M. E.; Almasan, A.; Macklis, R. M.; Supinski, G.; Nethery, D.; DiMarco, A. Regulation of CD20 expression by radiation-induced changes in intracellular redox status. Free Radical Biol. Med. 2008, 44 (4), 614-623.
23. Friedman, M. Chemistry, biochemistry, and safety of acrylamide. A review. J. Agric. Food Chem. 2003, 51 (16), 4504-4526.
24. Besaratinia, A.; Pfeifer, G. P. Genotoxicity of acrylamide and glycidamide. J Natl Cancer Inst 2004, 96 (13), 1023-1029.
25. Ghanayem, B. I.; Witt, K. L.; Kissling, G. E.; Tice, R. R.; Recio, L. Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect. Mutat. Res. 2005, 578 (1-2), 284-297.
26. Srivastava, S.; Sabri, M. I.; Agrawal, A. K.; Seth, P. K. Effect of single and repeated doses of acrylamide and bis-acrylamide on glutathione-S-transferase and dopamine receptors in rat brain. Brain Res. 1986, 371 (2), 319-323.
27. Park, J.; Kamendulis, L. M.; Friedman, M. A.; Klaunig, J. E. Acrylamide-induced cellular transformation. Toxicol. Sci. 2002, 65 (2), 177-183.
28. Speit, G.; Dennog, C.; Radermacher, P.; Rothfuss, A. Genotoxicity of hyperbaric oxygen. Mutat. Res. 2002, 512 (2-3), 111-9.
29. Weisburger, J. H. Antimutagenesis and anticarcinogenesis, from the past to the future. Mutat. Res. 2001, 480-481, 23-35.
30. Rukkumani, R.; Aruna, K.; Varma, P. S.; Rajasekaran, K. N.; Menon, V. P. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J. Pharm. Pharm. Sci. 2004, 7 (2), 274-283.
31. Gebhart, E. Anticlastogenicity in cultured mammalian cells. Mutat. Res. 1992, 267 (2), 211-20.
32. Biswas, S. K.; McClure, D.; Jimenez, L. A.; Megson, I. L.; Rahman, I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid. Redox Signal. 2005, 7 (1-2), 32-41.
33. Blasiak, J.; Gloc, E.; Wozniak, K.; Czechowska, A. Genotoxicity of acrylamide in human lymphocytes. Chem,-Biol. Interact, 2004, 149 (2-3), 137-149.
34. Friedman, M.; Levin, C. E. Review of methods for the reduction of dietary content and toxicity of acrylamide. J. Agric. Food Chem. 2008, 56 (15), 6113-6140.