Diphlorethohydroxycarmalol inhibits interleukin-6 production by regulating NF-κB, STAT5 and SOCS1 in lipopolysaccharide-stimulated RAW264.7 cells

Marine Drugs

Volumn 13, Issue 4, 2015, Pages 2141-2157

  Kang, Na Jin ^a   Han, Sang Chul ^b   Kang, Gyeoung Jin ^b   Koo, Dong Hwan ^a   Koh, Young Sang ^a,b   Hyun, Jin Won ^a,b   Lee, Nam Ho ^a   Ko, Mi Hee ^c   Kang, Hee Kyoung ^a,b   Yoo, Eun Sook ^a,b  

^a Jeju National University   (South Korea)

^b Jeju National University School of Medicine   (South Korea)

^c JejuTechnopark   (South Korea)

Author keywords

Diphlorethohydroxycarmalol (DPHC); IL 6; Inflammation; Jak STAT; LPS; NF B; SOCS

Indexed keywords

CYTOKINE; DIPHLORETHOHYDROXYCARMALOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE 2; LIPOPOLYSACCHARIDE; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TANNIN DERIVATIVE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; INTERLEUKIN-6, MOUSE; LIPOPOLYSACCHARIDE, ESCHERICHIA COLI 0111 B4; NONSTEROID ANTIINFLAMMATORY AGENT; SOCS1 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONCENTRATION (PARAMETERS); CYTOKINE PRODUCTION; DOWN REGULATION; MACROPHAGE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BROWN ALGA; CHEMISTRY; CUTANEOUS DRUG ADMINISTRATION; DERMATITIS, ATOPIC; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PACIFIC OCEAN; PATHOLOGY; RAW 264.7 CELL LINE; SKIN; SOUTH KOREA;

ISHIGE; PHAEOPHYCEAE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DERMATITIS, ATOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; HETEROCYCLIC COMPOUNDS, 3-RING; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED BALB C; NF-KAPPA B; PACIFIC OCEAN; PHAEOPHYTA; RAW 264.7 CELLS; REPUBLIC OF KOREA; SKIN; SPECIFIC PATHOGEN-FREE ORGANISMS; STAT5 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84928502999     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13042141     Document Type: Article

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