Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway

Marine Drugs

Volumn 11, Issue 9, 2013, Pages 3272-3287

  Chae, Doobyeong ^a   Manzoor, Zahid ^a   Kim, Sung Chun ^b   Kim, Sohyun ^a   Oh, Tae Heon ^b   Yoo, Eun Sook ^a   Kang, Hee Kyoung ^a   Hyun, Jin Won ^a   Lee, Nam Ho ^b   Ko, Mi Hee ^c   Koh, Young Sang ^a  

^a Jeju National University School of Medicine   (South Korea)

^b Jeju National University   (South Korea)

^c Jeju Biodiversity Research Institute   (South Korea)

Author keywords

Activator protein 1; Apo 9 fucoxanthinone; ERK1 2; Inflammation; Pro inflammatory cytokine; Sargassum muticum

Indexed keywords

ANTIINFLAMMATORY AGENT; APO 9' FUCOXANTHINONE; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLANT EXTRACT; PROTEIN P40; SARGASSUM MUTICUM EXTRACT; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NOS2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DENDRITIC CELL; DENSITOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IC 50; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SARGASSUM; SARGASSUM MUTICUM; ANIMAL; BROWN ALGA; CELL LINE; CELL STRAIN HEK293; CHEMISTRY; DRUG EFFECT; HUMAN; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; DRUG EFFECTS; HEK293 CELL LINE;

ALGAE; SARGASSUM MUTICUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CPG ISLANDS; HEK293 CELLS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-2; INTERLEUKIN-6; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHAEOPHYTA; PHOSPHORYLATION; PLANT EXTRACTS; SARGASSUM; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84885068163     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11093272     Document Type: Article

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