Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 47, 2005, Pages 17089-17094

  Kimura, Akihiro ^a,b   Naka, Tetsuji ^b   Muta, Tatsushi ^d   Takeuchi, Osamu ^c   Akira, Shizuo ^c   Kawase, Ichiro ^b   Kishimoto, Tadamitsu ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Innate immunity; Jak2; Stat5; Toll like receptor signal

Indexed keywords

BETA INTERFERON; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE 2; JANUS KINASE INHIBITOR; LIPOPOLYSACCHARIDE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN P50; STAT PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; INNATE IMMUNITY; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELL LINE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOKINES; DOWN-REGULATION; INTERLEUKIN-6; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MICE; MICE, MUTANT STRAINS; NF-KAPPA B P50 SUBUNIT; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 28044461950     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508517102     Document Type: Article

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