CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection

Journal of Virology

Volumn 78, Issue 14, 2004, Pages 7528-7535

  Debes, Gudrun F ^a,b,e   Bonhagen, Kerstin ^b   Wolff, Thorsten ^c   Kretschmer, Ute ^a,b   Krautwald, Stefan ^d   Kamradt, Thomas ^b   Hamann, Alf ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^c ROBERT KOCH INSTITUTE   (Germany)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; L SELECTIN; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL TYPE; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; FEMALE; INFLAMMATION; INFLUENZA; INFLUENZA VIRUS A; LUNG PARENCHYMA; LYMPH NODE; MALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT INFECTION; VIRUS IMMUNITY;

ANIMALS; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; IMMUNOLOGIC MEMORY; INFLUENZA A VIRUS; INTERFERON TYPE II; L-SELECTIN; LUNG; LYMPH NODES; MALE; MICE; ORGAN SPECIFICITY; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, CHEMOKINE; SPLEEN; T-LYMPHOCYTES, REGULATORY;

EID: 3142717603     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.14.7528-7535.2004     Document Type: Article

References (44)

1. Ager, A., and M. T. Drayson. 1988. Lymphocyte migration in the rat, p. 19. In A. J. Husband (ed.), Migration and homing of lymphoid cells, vol. 1. CRC Press, Boca Raton, Fla.
2. Balmelli, C., S. Demotz, H. Acha-Orbea, P. De Grandi, and D. Nardelli-Haefliger. 2002. Trachea, lung, and tracheobronchial lymph nodes are the major sites where antigen-presenting cells are detected after nasal vaccination of mice with human papillomavirus type 16 virus-like particles. J. Virol. 76:12596-12602.
3. Baumgarth, N., and A. Kelso. 1996. Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection. Eur. J. Immunol. 26:2189-2197.
4. +-T-cell-deficient mice. J. Virol. 76:12388-12393.
5. Bot, A., S. Bot, and C. A. Bona. 1998. Protective role of gamma interferon during the recall response to influenza virus. J. Virol. 72:6637-6645.
6. Campbell, D. J., G. F. Debes, B. Johnston, E. Wilson, and E. C. Butcher. 2003. Targeting T cell responses by selective chemokine receptor expression. Semin. Immunol. 15:277-286.
7. Campbell, J. J., C. E. Brightling, F. A. Symon, S. Qin, K. E. Murphy, M. Hodge, D. P. Andrew, L. Wu, E. C. Butcher, and A. J. Wardlaw. 2001. Expression of chemokine receptors by lung T cells from normal and asthmatic subjects. J. Immunol. 166:2842-2848.
8. Campbell, J. J., and E. C. Butcher. 2000. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12:336-341.
9. Campbell, J. J., K. E. Murphy, E. J. Kunkel, C. E. Brightling, D. Soler, Z. Shen, J. Boisvert, H. B. Greenberg, M. A. Vierra, S. B. Goodman, M. C. Genovese, A. J. Wardlaw, E. C. Butcher, and L. Wu. 2001. CCR7 expression and memory T cell diversity in humans. J. Immunol. 166:877-884.
10. + memory T cells in nonlymphoid tissues express a highly activated phenotype. J. Immunol. 169:6655-6658.
11. Chao, C. C., R. Jensen, and M. O. Dailey. 1997. Mechanisms of L-selectin regulation by activated T cells. J. Immunol. 159:1686-1694.
12. Clemons, K. V., G. Grunig, R. A. Sobel, L. F. Mirels, D. M. Rennick, and D. A. Stevens. 2000. Role of IL-10 in invasive aspergillosis: increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis. Clin. Exp. Immunol. 122:186-191.
13. Constant, S. L., J. L. Brogdon, D. A. Piggott, C. A. Herrick, I. Visintin, N. H. Ruddle, and K. Bottomly. 2002. Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. J. Clin. Investig. 110:1441-1448.
14. D'Ambrosio, D., M. Mariani, P. Panina-Bordignon, and F. Sinigaglia. 2001. Chemokines and their receptors guiding T lymphocyte recruitment in lung inflammation. Am. J. Respir. Crit. Care Med. 164:1266-1275.
15. + T cells express functional CCR7. J. Immunol. 168:5441-5447.
16. + T-cell mechanisms in the control of respiratory virus infections. Immunol. Rev. 159:105-117.
17. Fernandes, D. M., and C. L. Baldwin. 1995. Interleukin-10 downregulates protective immunity to Brucella abortus. Infect. Immun. 63:1130-1133.
18. Förster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23-33.
19. + T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J. Immunol. 157:798-805.
20. + T helper type 2 T lymphocytes do not promote recovery from experimental virus infection. J. Exp. Med. 180:1273-1282.
21. Gunn, M. D., S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L. T. Williams, and H. Nakano. 1999. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189:451-460.
22. Gunn, M. D., K. Tangemann, C. Tam, J. G. Cyster, S. D. Rosen, and L. T. Williams. 1998. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc. Natl. Acad. Sci. USA 95:258-263.
23. + T cells in the lung airways depends on proliferation. J. Immunol. 169:4976-4981.
24. + T cells persist in the lungs following recovery from respiratory virus infections. J. Immunol. 166:1813-1822.
25. + T cells that persist in the lungs. J. Exp. Med. 193:981-986.
26. Infante-Duarte, C., and T. Kamradt. 1999. Th1/Th2 balance in infection. Springer Semin. Immunopathol. 21:317-338.
27. Itakura, M., A. Tokuda, H. Kimura, S. Nagai, H. Yoneyama, N. Onai, S. Ishikawa, T. Kuriyama, and K. Matsushima. 2001. Blockade of secondary lymphoid tissue chemokine exacerbates Propionibacterium acnes-induced acute lung inflammation. J. Immunol. 166:2071-2079.
28. Kim, C. H., L. Rott, E. J. Kunkel, M. C. Genovese, D. P. Andrew, L. Wu, and E. C. Butcher. 2001. Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Investig. 108:1331-1339.
29. Lehmann, C., A. Wilkening, D. Leiber, A. Markus, N. Krug, R. Pabst, and T. Tschernig. 2001. Lymphocytes in the bronchoalveolar space reenter the lung tissue by means of the alveolar epithelium, migrate to regional lymph nodes, and subsequently rejoin the systemic immune system. Anat. Rec. 264:229-236.
30. Liang, S., K. Mozdzanowska, G. Palladino, and W. Gerhard. 1994. Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity. J. Immunol. 152:1653-1661.
31. Lo, J. C., R. K. Chin, Y. Lee, H. S. Kang, Y. Wang, J. V. Weinstock, T. Banks, C. F. Ware, G. Franzoso, and Y. X. Fu. 2003. Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J. Clin. Investig. 112:1495-1505.
32. Lund, F. E., S. Partida-Sanchez, B. O. Lee, K. L. Kusser, L. Hartson, R. J. Hogan, D. L. Woodland, and T. D. Randall. 2002. Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immunol. 169:5236-5243.
33. Nicholson, K. G. 1998. Human influenza, p. 219-264. In K. G. Nicholson, R. G. Webster, and A. J. Hay (ed.), Textbook of influenza. Blackwell Sciences Ltd., Oxford, United Kingdom.
34. Pabst, R., and R. M. Binns. 1995. Lymphocytes migrate from the bronchoalveolar space to regional bronchial lymph nodes. Am. J. Respir. Crit. Care Med. 151:495-499.
35. Porgador, A., H. F. Staats, Y. Itoh, and B. L. Kelsall. 1998. Intranasal immunization with cytotoxic T-lymphocyte epitope peptide and mucosal adjuvant cholera toxin: selective augmentation of peptide-presenting dendritic cells in nasal mucosa-associated lymphoid tissue. Infect. Immun. 66:5876-5881.
36. Reinhardt, R. L., D. C. Bullard, C. T. Weaver, and M. K. Jenkins. 2003. Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J. Exp. Med. 197:751-762.
37. Román, E., E. Miller, A. Harmsen, J. Wiley, U. H. Von Andrian, G. Huston, and S. L. Swain. 2002. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J. Exp. Med. 196:957-968.
38. Saeki, H., A. M. Moore, M. J. Brown, and S. T. Hwang. 1999. Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162:2472-2475.
39. Sallusto, F., D. Lenig, R. Förster, M. Lipp, and A. Lanzavecchia. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708-712.
40. + T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions. J. Exp. Med. 198:1011-1021.
41. Sewnath, M. E., D. P. Olszyna, R. Birjmohun, F. J. ten Kate, D. J. Gouma, and T. van Der Poll. 2001. IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J. Immunol. 166:6323-6331.
42. - memory T cells do not differ in immediate effector cell function. J. Immunol. 169:638-641.
43. Von Andrian, U. H., and T. R. Mempel. 2003. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3:867-878.
44. Zuercher, A. W., S. E. Coffin, M. C. Thurnheer, P. Fundova, and J. J. Cebra. 2002. Nasal-associated lymphoid tissue is a mucosal inductive site for virus-specific humoral and cellular immune responses. J. Immunol. 168:1796-1803.