Product formation by the promiscuous lanthipeptide synthetase ProcM is under kinetic control

Journal of the American Chemical Society

Volumn 137, Issue 15, 2015, Pages 5140-5148

  Yu, Yi ^a   Mukherjee, Subha ^b   Van Der Donk, Wilfred A ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CYCLIZATION; LIGANDS; REGIOSELECTIVITY; ZINC;

CYCLIZATION RATES; HIGH SELECTIVITY; KINETIC CONTROL; NATURAL PRODUCTS; PRODUCT FORMATION; RING TOPOLOGY; SINGLE PRODUCT; THERMODYNAMIC CONTROL;

SUBSTRATES;

ALANINE; HISTIDINE; LANTHIONINE; LANTHIPEPTIDE SYNTHETASE; SYNTHETASE; UNCLASSIFIED DRUG; ZINC; LIGASE; PEPTIDE;

ARTICLE; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; MUTATION; STEREOCHEMISTRY; THERMODYNAMICS; BIOCATALYSIS; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; GENETICS; KINETICS; LIQUID CHROMATOGRAPHY; METABOLISM; PROCHLOROCOCCUS; PROTEIN PROCESSING;

BIOCATALYSIS; CHROMATOGRAPHY, LIQUID; KINETICS; LIGASES; MUTATION; PEPTIDES; PROCHLOROCOCCUS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84928479646     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b01409     Document Type: Article

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