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Volumn 22, Issue 11, 2013, Pages 1478-1489

Insights into the evolution of lanthipeptide biosynthesis

Author keywords

Cyclic peptide; Dehydration; Glutamylation; Kinase; Labionin; Lanthionine; Lantibiotics; Nisin; Phosphothreonine lyase; Posttranslational modification

Indexed keywords

AMINO ACID; ENZYME; LANTHIPEPTIDE; LANTIBIOTIC; NATURAL PRODUCT; PEPTIDE; SULFIDE; UNCLASSIFIED DRUG;

EID: 84892704003     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2358     Document Type: Review
Times cited : (45)

References (62)
  • 2
    • 74049115080 scopus 로고    scopus 로고
    • Follow the leader: The use of leader peptides to guide natural product biosynthesis
    • Oman TJ, van der Donk WA (2010) Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol 6:9-18.
    • (2010) Nat Chem Biol , vol.6 , pp. 9-18
    • Oman, T.J.1    Van Der Donk, W.A.2
  • 3
    • 84861649020 scopus 로고    scopus 로고
    • Discovery, biosynthesis, and engineering of lantipeptides
    • Knerr PJ, van der Donk WA (2012) Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem 81:479-505.
    • (2012) Annu Rev Biochem , vol.81 , pp. 479-505
    • Knerr, P.J.1    Van Der Donk, W.A.2
  • 4
    • 0023912839 scopus 로고
    • Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
    • Schnell N, Entian K-D, Schneider U, Götz F, Zahner H, Kellner R, Jung G (1988) Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature 333:276-278.
    • (1988) Nature , vol.333 , pp. 276-278
    • Schnell, N.1    Entian, K.-D.2    Schneider, U.3    Götz, F.4    Zahner, H.5    Kellner, R.6    Jung, G.7
  • 5
    • 78651404410 scopus 로고    scopus 로고
    • Morphogenetic signaling molecules of the streptomycetes
    • Willey JM, Gaskell AA (2011) Morphogenetic signaling molecules of the streptomycetes. Chem Rev 111:174-187.
    • (2011) Chem Rev , vol.111 , pp. 174-187
    • Willey, J.M.1    Gaskell, A.A.2
  • 8
    • 38949166717 scopus 로고    scopus 로고
    • Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin
    • Lubelski J, Rink R, Khusainov R, Moll GN, Kuipers OP (2008) Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin. Cell Mol Life Sci 65:455-476.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 455-476
    • Lubelski, J.1    Rink, R.2    Khusainov, R.3    Moll, G.N.4    Kuipers, O.P.5
  • 11
    • 79953242162 scopus 로고    scopus 로고
    • Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrugresistant Gram-positive pathogens
    • Jabes D, Brunati C, Candiani G, Riva S, Romano G, Donadio S (2011) Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrugresistant Gram-positive pathogens. Antimicrob Agents Chemother 55:1671-1676.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 1671-1676
    • Jabes, D.1    Brunati, C.2    Candiani, G.3    Riva, S.4    Romano, G.5    Donadio, S.6
  • 12
    • 70349096824 scopus 로고    scopus 로고
    • Emerging treatments in cystic fibrosis
    • Jones AM, Helm JM (2009) Emerging treatments in cystic fibrosis. Drugs 69:1903-1910.
    • (2009) Drugs , vol.69 , pp. 1903-1910
    • Jones, A.M.1    Helm, J.M.2
  • 14
    • 0034673170 scopus 로고    scopus 로고
    • Reactions of Pseudomonas 7A glutaminaseasparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu
    • Ortlund E, Lacount MW, Lewinski K, Lebioda L (2000) Reactions of Pseudomonas 7A glutaminaseasparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu. Biochemistry 39:1199-1204.
    • (2000) Biochemistry , vol.39 , pp. 1199-1204
    • Ortlund, E.1    Lacount, M.W.2    Lewinski, K.3    Lebioda, L.4
  • 15
    • 0034604269 scopus 로고    scopus 로고
    • Identification of catalytic nucleophile of Escherichia coli gamma-glutamyltranspeptidase by gammamonofluorophosphono derivative of glutamic acid: Nterminal thr-391 in small subunit is the nucleophile
    • Inoue M, Hiratake J, Suzuki H, Kumagai H, Sakata K (2000) Identification of catalytic nucleophile of Escherichia coli gamma-glutamyltranspeptidase by gammamonofluorophosphono derivative of glutamic acid: Nterminal thr-391 in small subunit is the nucleophile. Biochemistry 39:7764-7771.
    • (2000) Biochemistry , vol.39 , pp. 7764-7771
    • Inoue, M.1    Hiratake, J.2    Suzuki, H.3    Kumagai, H.4    Sakata, K.5
  • 16
    • 0344823660 scopus 로고    scopus 로고
    • SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins
    • Okeley NM, Paul M, Stasser JP, Blackburn N, van der Donk WA (2003) SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry 42:13613-13624.
    • (2003) Biochemistry , vol.42 , pp. 13613-13624
    • Okeley, N.M.1    Paul, M.2    Stasser, J.P.3    Blackburn, N.4    Van Der Donk, W.A.5
  • 17
    • 33644854595 scopus 로고    scopus 로고
    • Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis
    • Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK (2006) Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science 311:1464-1467.
    • (2006) Science , vol.311 , pp. 1464-1467
    • Li, B.1    Yu, J.P.2    Brunzelle, J.S.3    Moll, G.N.4    Van Der Donk, W.A.5    Nair, S.K.6
  • 18
    • 0032587329 scopus 로고    scopus 로고
    • Zinc-catalyzed sulfur alkylation: Insights from protein farnesyltransferase
    • Hightower KE, Fierke CA (1999) Zinc-catalyzed sulfur alkylation: insights from protein farnesyltransferase. Curr Opin Chem Biol 3:176-181.
    • (1999) Curr Opin Chem Biol , vol.3 , pp. 176-181
    • Hightower, K.E.1    Fierke, C.A.2
  • 19
  • 20
    • 0034682901 scopus 로고    scopus 로고
    • Characterization of p40/GPR69A as a peripheral membrane protein related to the lantibiotic synthetase component C
    • Bauer H, Mayer H, Marchler-Bauer A, Salzer U, Prohaska R (2000) Characterization of p40/GPR69A as a peripheral membrane protein related to the lantibiotic synthetase component C. Biochem Biophys Res Commun 275:69-74.
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 69-74
    • Bauer, H.1    Mayer, H.2    Marchler-Bauer, A.3    Salzer, U.4    Prohaska, R.5
  • 21
    • 0035897569 scopus 로고    scopus 로고
    • Characterization of rat LANCL1, a novel member of the lanthionine synthetase C-like protein family, highly expressed in testis and brain
    • Mayer H, Bauer H, Breuss J, Ziegler S, Prohaska R (2001) Characterization of rat LANCL1, a novel member of the lanthionine synthetase C-like protein family, highly expressed in testis and brain. Gene 269:73-80.
    • (2001) Gene , vol.269 , pp. 73-80
    • Mayer, H.1    Bauer, H.2    Breuss, J.3    Ziegler, S.4    Prohaska, R.5
  • 23
    • 3843091511 scopus 로고    scopus 로고
    • The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor
    • Kodani S, Hudson ME, Durrant MC, Buttner MJ, Nodwell JR, Willey JM (2004) The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor. Proc Natl Acad Sci USA 101:11448-11453.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11448-11453
    • Kodani, S.1    Hudson, M.E.2    Durrant, M.C.3    Buttner, M.J.4    Nodwell, J.R.5    Willey, J.M.6
  • 24
    • 77950563372 scopus 로고    scopus 로고
    • Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights
    • Goto Y, Li B, Claesen J, Shi Y, Bibb MJ, van der Donk WA (2010) Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol 8:e1000339.
    • (2010) PLoS Biol , vol.8
    • Goto, Y.1    Li, B.2    Claesen, J.3    Shi, Y.4    Bibb, M.J.5    Van Der Donk, W.A.6
  • 25
    • 77953528770 scopus 로고    scopus 로고
    • In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification
    • Müller WM, Schmiederer T, Ensle P, Süssmuth RD (2010) In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification. Angew Chem Int Ed 49:2436-2440.
    • (2010) Angew Chem Int Ed , vol.49 , pp. 2436-2440
    • Müller, W.M.1    Schmiederer, T.2    Ensle, P.3    Süssmuth, R.D.4
  • 26
    • 79952097307 scopus 로고    scopus 로고
    • Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family
    • Goto Y, Ökesli A, van der Donk WA (2011) Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family. Biochemistry 50:891-898.
    • (2011) Biochemistry , vol.50 , pp. 891-898
    • Goto, Y.1    Ökesli, A.2    Van Der Donk, W.A.3
  • 27
    • 33847154642 scopus 로고    scopus 로고
    • The phosphothreonine lyase activity of a bacterial type III effector family
    • Li H, Xu H, Zhou Y, Zhang J, Long C, Li S, Chen S, Zhou JM, Shao F (2007) The phosphothreonine lyase activity of a bacterial type III effector family. Science 315:1000-1003.
    • (2007) Science , vol.315 , pp. 1000-1003
    • Li, H.1    Xu, H.2    Zhou, Y.3    Zhang, J.4    Long, C.5    Li, S.6    Chen, S.7    Zhou, J.M.8    Shao, F.9
  • 28
    • 84868094646 scopus 로고    scopus 로고
    • Biosynthesis of the class III lantipeptide catenulipeptin
    • Wang H, van der Donk WA (2012) Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol 7: 1529-1535.
    • (2012) ACS Chem Biol , vol.7 , pp. 1529-1535
    • Wang, H.1    Van Der Donk, W.A.2
  • 29
    • 84866449155 scopus 로고    scopus 로고
    • Curvopeptin: A new lanthionine-containing class III lantibiotic and its co-substrate promiscuous synthetase
    • Krawczyk B, Völler GH, Völler J, Ensle P, Süssmuth RD (2012) Curvopeptin: a new lanthionine-containing class III lantibiotic and its co-substrate promiscuous synthetase. ChemBioChem 13:2065-2071.
    • (2012) ChemBioChem , vol.13 , pp. 2065-2071
    • Krawczyk, B.1    Völler, G.H.2    Völler, J.3    Ensle, P.4    Süssmuth, R.D.5
  • 30
    • 38449108932 scopus 로고    scopus 로고
    • Evolutionary mechanisms underlying secondary metabolite diversity
    • 121-140
    • Jenke-Kodama H, Müller R, Dittmann E (2008) Evolutionary mechanisms underlying secondary metabolite diversity. Prog Drug Res 65:119, 121-140.
    • (2008) Prog Drug Res , vol.65 , pp. 119
    • Jenke-Kodama, H.1    Müller, R.2    Dittmann, E.3
  • 31
    • 0027385948 scopus 로고
    • Model studies of lantibiotic biogenesis
    • Toogood PL (1993) Model studies of lantibiotic biogenesis. Tetrahedron Lett 34:7833-7836.
    • (1993) Tetrahedron Lett , vol.34 , pp. 7833-7836
    • Toogood, P.L.1
  • 32
    • 0034676587 scopus 로고    scopus 로고
    • Facile chemoselective synthesis of dehydroalanine-containing peptides
    • Okeley NM, Zhu Y, van der Donk WA (2000) Facile chemoselective synthesis of dehydroalanine-containing peptides. Org Lett 2:3603-3606.
    • (2000) Org Lett , vol.2 , pp. 3603-3606
    • Okeley, N.M.1    Zhu, Y.2    Van Der Donk, W.A.3
  • 34
    • 0037129424 scopus 로고    scopus 로고
    • Biomimetic stereoselective formation of methyllanthionine
    • Zhou H, van der Donk WA (2002) Biomimetic stereoselective formation of methyllanthionine. Org Lett 4: 1335-1338.
    • (2002) Org Lett , vol.4 , pp. 1335-1338
    • Zhou, H.1    Van Der Donk, W.A.2
  • 35
    • 0142094530 scopus 로고    scopus 로고
    • Biomimetic studies on the mechanism of stereoselective lanthionine formation
    • Zhu Y, Gieselman M, Zhou H, Averin O, van der Donk WA (2003) Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem 1:3304-3315.
    • (2003) Org Biomol Chem , vol.1 , pp. 3304-3315
    • Zhu, Y.1    Gieselman, M.2    Zhou, H.3    Averin, O.4    Van Der Donk, W.A.5
  • 37
    • 84878560267 scopus 로고    scopus 로고
    • Ribosomally synthesized and post-translationally modified peptide natural products: New insights into the role of leader and core peptides during biosynthesis
    • Yang X, van der Donk WA (2013) Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chem Eur J 19:7662-7677.
    • (2013) Chem Eur J , vol.19 , pp. 7662-7677
    • Yang, X.1    Van Der Donk, W.A.2
  • 38
    • 70350031573 scopus 로고    scopus 로고
    • Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin
    • Lubelski J, Khusainov R, Kuipers OP (2009) Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin. J Biol Chem 284:25962-25972.
    • (2009) J Biol Chem , vol.284 , pp. 25962-25972
    • Lubelski, J.1    Khusainov, R.2    Kuipers, O.P.3
  • 39
    • 69349105507 scopus 로고    scopus 로고
    • Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry
    • Lee MV, Ihnken LA, You YO, McClerren AL, van der Donk WA, Kelleher NL (2009) Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc 131:12258-12264.
    • (2009) J Am Chem Soc , vol.131 , pp. 12258-12264
    • Lee, M.V.1    Ihnken, L.A.2    You, Y.O.3    McClerren, A.L.4    Van Der Donk, W.A.5    Kelleher, N.L.6
  • 40
    • 84862528396 scopus 로고    scopus 로고
    • Deuterium labeled peptides give insights into the directionality of class III lantibiotic synthetase LabKC
    • Krawczyk B, Ensle P, Müller WM, Süssmuth RD (2012) Deuterium labeled peptides give insights into the directionality of class III lantibiotic synthetase LabKC. J Am Chem Soc 134:9922.
    • (2012) J Am Chem Soc , vol.134 , pp. 9922
    • Krawczyk, B.1    Ensle, P.2    Müller, W.M.3    Süssmuth, R.D.4
  • 42
    • 36048994654 scopus 로고    scopus 로고
    • NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides
    • Rink R, Kluskens LD, Kuipers A, Driessen AJ, Kuipers OP, Moll GN (2007) NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides. Biochemistry 46:13179-13189.
    • (2007) Biochemistry , vol.46 , pp. 13179-13189
    • Rink, R.1    Kluskens, L.D.2    Kuipers, A.3    Driessen, A.J.4    Kuipers, O.P.5    Moll, G.N.6
  • 44
    • 43549100204 scopus 로고    scopus 로고
    • Use of lantibiotic synthetases for the preparation of bioactive constrained peptides
    • Levengood MR, van der Donk WA (2008) Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett 18:3025-3028.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 3025-3028
    • Levengood, M.R.1    Van Der Donk, W.A.2
  • 45
    • 47249108199 scopus 로고    scopus 로고
    • The importance of the leader sequence for directing lanthionine formation in lacticin 481
    • Patton GC, Paul M, Cooper LE, Chatterjee C, van der Donk WA (2008) The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry 47:7342-7351.
    • (2008) Biochemistry , vol.47 , pp. 7342-7351
    • Patton, G.C.1    Paul, M.2    Cooper, L.E.3    Chatterjee, C.4    Van Der Donk, W.A.5
  • 46
    • 0027327107 scopus 로고
    • Structure, organization, and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis
    • Piard JC, Kuipers OP, Rollema HS, Desmazeaud MJ, de Vos WM (1993) Structure, organization, and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis. J Biol Chem 268: 16361-16368.
    • (1993) J Biol Chem , vol.268 , pp. 16361-16368
    • Piard, J.C.1    Kuipers, O.P.2    Rollema, H.S.3    Desmazeaud, M.J.4    De Vos, W.M.5
  • 47
    • 0027199706 scopus 로고
    • Genetics of bacteriocins produced by lactic acid bacteria
    • Klaenhammer TR (1993) Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol Rev 12: 39-85.
    • (1993) FEMS Microbiol Rev , vol.12 , pp. 39-85
    • Klaenhammer, T.R.1
  • 51
    • 77952511174 scopus 로고    scopus 로고
    • Expansion of ribosomally produced natural products: A nitrile hydratase-and Nif11-related precursor family
    • Haft DH, Basu MK, Mitchell DA (2010) Expansion of ribosomally produced natural products: a nitrile hydratase-and Nif11-related precursor family. BMC Biol 8: 70
    • (2010) BMC Biol , vol.8 , pp. 70
    • Haft, D.H.1    Basu, M.K.2    Mitchell, D.A.3
  • 52
    • 84861624891 scopus 로고    scopus 로고
    • Structural characterization of four prochlorosins: A novel class of lantipeptides produced by planktonic marine cyanobacteria
    • Tang W, van der Donk WA (2012) Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry 51:4271-4279.
    • (2012) Biochemistry , vol.51 , pp. 4271-4279
    • Tang, W.1    Van Der Donk, W.A.2
  • 54
    • 0000816291 scopus 로고    scopus 로고
    • Alkyl transfer to metal thiolates: Kinetics, active species identification, and relevance to the DNA methyl phosphotriester repair center of Escherichia coli Ada
    • Wilker JJ, Lippard SJ (1997) Alkyl transfer to metal thiolates: kinetics, active species identification, and relevance to the DNA methyl phosphotriester repair center of Escherichia coli Ada. Inorg Chem 36:969-978.
    • (1997) Inorg Chem , vol.36 , pp. 969-978
    • Wilker, J.J.1    Lippard, S.J.2
  • 55
    • 0034839228 scopus 로고    scopus 로고
    • Methylation of neutral pseudotetrahedral zinc thiolate complexes: Model reactions for alkyl group transfer to sulfur by zinc-containing enzymes
    • Warthen CR, Hammes BS, Carrano CJ, Crans DC (2001) Methylation of neutral pseudotetrahedral zinc thiolate complexes: model reactions for alkyl group transfer to sulfur by zinc-containing enzymes. J Biol Inorg Chem 6:82-90.
    • (2001) J Biol Inorg Chem , vol.6 , pp. 82-90
    • Warthen, C.R.1    Hammes, B.S.2    Carrano, C.J.3    Crans, D.C.4
  • 56
    • 0035914908 scopus 로고    scopus 로고
    • Functional modeling of cobalamine-independent methionine synthase with pyrazolylborate-zinc-thiolate complexes
    • Brand U, Rombach M, Seebacher J, Vahrenkamp H (2001) Functional modeling of cobalamine-independent methionine synthase with pyrazolylborate-zinc-thiolate complexes. Inorg Chem 40:6151-6157.
    • (2001) Inorg Chem , vol.40 , pp. 6151-6157
    • Brand, U.1    Rombach, M.2    Seebacher, J.3    Vahrenkamp, H.4
  • 57
    • 0037389593 scopus 로고    scopus 로고
    • Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates
    • Chiou SJ, Riordan CG, Rheingold AL (2003) Synthetic modeling of zinc thiolates: quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates. Proc Natl Acad Sci USA 100:3695-3700.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3695-3700
    • Chiou, S.J.1    Riordan, C.G.2    Rheingold, A.L.3
  • 58
    • 13844316746 scopus 로고    scopus 로고
    • Enterococcal cytolysin: A novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells
    • Cox CR, Coburn PS, Gilmore MS (2005) Enterococcal cytolysin: a novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells. Curr Protein Pept Sci 6:77-84.
    • (2005) Curr Protein Pept Sci , vol.6 , pp. 77-84
    • Cox, C.R.1    Coburn, P.S.2    Gilmore, M.S.3
  • 59
    • 84874115767 scopus 로고    scopus 로고
    • The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry
    • Tang W, van der Donk WA (2013) The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol 9:157-159.
    • (2013) Nat Chem Biol , vol.9 , pp. 157-159
    • Tang, W.1    Van Der Donk, W.A.2
  • 60
    • 84861445578 scopus 로고    scopus 로고
    • Characterization of new class III lantibiotics-erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing
    • Völler GH, Krawczyk JM, Pesic A, Krawczyk B, Nachtigall J, Süssmuth RD (2012) Characterization of new class III lantibiotics- erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing. ChemBioChem 13:1174-1183.
    • (2012) ChemBioChem , vol.13 , pp. 1174-1183
    • Völler, G.H.1    Krawczyk, J.M.2    Pesic, A.3    Krawczyk, B.4    Nachtigall, J.5    Süssmuth, R.D.6
  • 62
    • 0030041310 scopus 로고    scopus 로고
    • Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR
    • Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K (1996) Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR. J Biochem 119:226-230.
    • (1996) J Biochem , vol.119 , pp. 226-230
    • Hosoda, K.1    Ohya, M.2    Kohno, T.3    Maeda, T.4    Endo, S.5    Wakamatsu, K.6


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