The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review)

International Journal of Molecular Medicine

Volumn 35, Issue 6, 2015, Pages 1483-1492

  Briggs, Michael D ^a   Bell, Peter A ^a   Pirog, Katarzyna A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cartilage; Disease mechanisms; Endoplasmic reticulum stress; Mouse models; Multiple epiphyseal dysplasia; Pseudoachondroplasia; Skeletal dysplasia

Indexed keywords

APOPTOSIS; BONE DISEASE; BONE DYSPLASIA; BONE LENGTH; CARTILAGE CELL; CELL PROLIFERATION; DISEASE SEVERITY; ENDOPLASMIC RETICULUM STRESS; GENE LOCUS; GENETIC DISORDER; GENOTYPE; HOMOLOGOUS RECOMBINATION; HUMAN; MISSENSE MUTATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PSEUDOACHONDROPLASIA; REVIEW; UNFOLDED PROTEIN RESPONSE; ACHONDROPLASIA; ANIMAL; CHONDRODYSPLASIA; DISEASE MODEL; GENETICS; METABOLISM; MOUSE; MUTATION; PATHOLOGY;

CARTILAGE OLIGOMERIC MATRIX PROTEIN; COMP PROTEIN, HUMAN; MATN3 PROTEIN, MOUSE; MATRILIN;

ACHONDROPLASIA; ANIMALS; CARTILAGE OLIGOMERIC MATRIX PROTEIN; DISEASE MODELS, ANIMAL; HUMANS; MATRILIN PROTEINS; MICE; MUTATION; OSTEOCHONDRODYSPLASIAS;

EID: 84928390200     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2158     Document Type: Review

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