A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

DMM Disease Models and Mechanisms

Volumn 6, Issue 6, 2013, Pages 1414-1425

  Gualeni, Benedetta ^a,c   Rajpar, M Helen ^a   Kellogg, Aaron ^b   Bell, Peter A ^a,c   Arvan, Peter ^b   Boot Handford, Raymond P ^a   Briggs, Michael D ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; THYROGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL PROLIFERATION; CELLULAR PARAMETERS; CELLULAR STRESS RESPONSE; CHONDRODYSPLASIA; CHRONIC STRESS; CONTROLLED STUDY; CYTOARCHITECTURE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GROWTH PLATE; GROWTH PLATE DYSPLASIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; BONE DEVELOPMENT; CELL PROLIFERATION; CHONDROCYTES; ENDOPLASMIC RETICULUM; GROWTH PLATE; MICE; MICE, TRANSGENIC; TRANSCRIPTION, GENETIC;

EID: 84888880961     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.013342     Document Type: Article

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