Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Liang, Guoyan ^a   Lian, Chengjie ^a   Huang, Di ^a   Gao, Wenjie ^a   Liang, Anjing ^a   Peng, Yan ^a   Ye, Wei ^a   Wu, Zizhao ^a   Su, Peiqiang ^b   Huang, Dongsheng ^a  

^a SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; COLLAGEN TYPE 2 ALPHA 1; PROCOLLAGEN; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARTILAGE CELL; CHONDRODYSPLASIA; ELECTRON MICROSCOPY; EMBRYO; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FETUS; GENE MUTATION; HETEROZYGOTE; HISTOLOGY; HOMOZYGOTE; HYPERTROPHY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; PATHOGENESIS; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; COLLAGEN TYPE II; DNA PRIMERS; ENDOPLASMIC RETICULUM STRESS; GENE KNOCK-IN TECHNIQUES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MODELS, ANIMAL; OSTEOCHONDRODYSPLASIAS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE;

EID: 84900331094     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086894     Document Type: Article

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