Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model

Neuroscience

Volumn 298, Issue , 2015, Pages 12-25

  Li, Y ^a,b,c   Guo, Y ^a,b,c   Wang, X ^a   Yu, X ^a,b,c   Duan, W ^a,b,c   Hong, K ^a,b,c   Wang, J ^a   Han, H ^a   Li, C ^a,b,c  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Key Laboratory of Hebei Neurology   (China)

^c Hebei Institute of Cardiocerebrovascular Diseases   (China)

Author keywords

Amyotrophic lateral sclerosis; Glial activation; Motor deficiency; SOD1 G93A transgenic mouse; Trehalose

Indexed keywords

DRINKING WATER; MUTANT PROTEIN; PROTEIN P62; SUPEROXIDE DISMUTASE; TREHALOSE; GLIAL FIBRILLARY ACIDIC PROTEIN; SOD1 G93A PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; AUTOPHAGY; BIOACCUMULATION; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME REPRESSION; FEMALE; GLIOSIS; LIGHT CHAIN; MOTONEURON; MOTOR DYSFUNCTION; MOUSE; MOUSE MODEL; MSOD1 MOUSE; NEUROPROTECTION; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROTAROD TEST; SCORING SYSTEM; SOD1 GENE; TRANSGENIC MOUSE; TREATMENT OUTCOME; AGE; ANIMAL; BODY WEIGHT; C57BL MOUSE; CELL CULTURE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOVEMENT DISORDERS; NEUROLOGIC EXAMINATION; NONPARAMETRIC TEST; PATHOLOGY; SURVIVAL ANALYSIS;

AGE FACTORS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; BODY WEIGHT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; MOVEMENT DISORDERS; NEUROLOGIC EXAMINATION; STATISTICS, NONPARAMETRIC; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS; TREHALOSE;

EID: 84928325579     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.03.061     Document Type: Article

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