The disaccharide trehalose inhibits proinflammatory phenotype activation in macrophages and prevents mortality in experimental septic shock

Shock

Volumn 27, Issue 1, 2007, Pages 91-96

  Minutoli, Letteria ^a   Altavilla, Domenica ^a   Bitto, Alessandra ^a   Polito, Francesca ^a   Bellocco, Ersilia ^b   Laganà, Giuseppina ^b   Giuliani, Daniela ^c   Fiumara, Tiziana ^a   Magazù, Salvatore ^b   Ruggeri, Pietro ^b   Guarini, Salvatore ^c   Squadrito, Francesco ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Endotoxin shock; ERK 1 2; JNK; LPS; Macrophages; TNF ; Trehalose

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BETA ACTIN; ENDOTOXIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; NITRITE; STRESS ACTIVATED PROTEIN KINASE; SUCROSE; TREHALOSE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENVIRONMENTAL STRESS; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; INFLAMMATION; MACROPHAGE ACTIVATION; MALE; MORTALITY; NONHUMAN; PERITONEUM; PHENOTYPE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA ENTERITIDIS; SEPTIC SHOCK; SUPERNATANT; WESTERN BLOTTING;

ANIMALS; DISEASE MODELS, ANIMAL; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; MACROPHAGES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, SEPTIC; TREHALOSE;

EID: 33845702456     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000235092.76292.bc     Document Type: Article

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