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84922381210
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Sympathetic nervous system and hypertension
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Hirooka Y, Kishi T, Ito K, Sunagawa K. Potential clinical application of recently discovered brain mechanisms involved in hypertension. Hypertension. 2013;62(6):995–1002.
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84860609944
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The human sympathetic nervous system: its relevance in hypertension and heart failure
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Parati G, Esler M. The human sympathetic nervous system: its relevance in hypertension and heart failure. Eur Heart J. 2012;33(9):1058–66. doi:10.1093/eurheartj/ehs041.
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NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension
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COI: 1:CAS:528:DC%2BC38XpsV2iu7s%3D, PID: 22723696
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Ye ZY, Li DP, Byun HS, Li L, Pan HL. NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension. J Neurosci. 2012;32(25):8560–8.
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Regulation of hypothalamic presympathetic neurons and sympathetic outflow by group II metabotropic glutamate receptors in spontaneously hypertensive rats
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COI: 1:CAS:528:DC%2BC3sXhtFamtr7P, PID: 23716583
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Ye ZY, Li DP, Pan HL. Regulation of hypothalamic presympathetic neurons and sympathetic outflow by group II metabotropic glutamate receptors in spontaneously hypertensive rats. Hypertension. 2013;62(2):255–62.
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GluR5 upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats
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Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL. mGluR5 upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats. J Neurosci. 2014;34(12):4309–17.
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Exercise training normalizes an increased neuronal excitability of NTS-projecting neurons of the hypothalamic paraventricular nucleus in hypertensive rats
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Stern JE, Sonner PM, Son SJ, Silva FC, Jackson K, Michelini LC. Exercise training normalizes an increased neuronal excitability of NTS-projecting neurons of the hypothalamic paraventricular nucleus in hypertensive rats. J Neurophysiol. 2012;107(10):2912–21.
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GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice
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COI: 1:CAS:528:DC%2BC2cXnsV2nuw%3D%3D, PID: 24270178
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Davern PJ, Chowdhury S, Jackson KL, Nguyen-Huu TP, Head GA. GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice. J Hypertens. 2014;32(2):352–62.
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10
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84855916560
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Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension
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COI: 1:CAS:528:DC%2BC38XovV2ksw%3D%3D, PID: 22219297
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Li DP, Byan HS, Pan HL. Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension. J Neurosci. 2012;32(1):372–80.
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Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension
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COI: 1:CAS:528:DC%2BC38XntFSnsb0%3D
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Ye ZY, Li L, Li DP, Pan HL. Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension. JBC. 2012;287(21):17438–46.
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84906342430
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Protein kinase CK2 contributes to diminished small conductance Ca2 + -activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension
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COI: 1:CAS:528:DC%2BC2cXhtlOmsL%2FK, PID: 24806793
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Pachuau J, Li DP, Chen SR, Lee HA, Pan HL. Protein kinase CK2 contributes to diminished small conductance Ca2 + -activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. J Neurochem. 2014;130(5):657–67.
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13
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84866466565
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Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus
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COI: 1:CAS:528:DC%2BC38XhsVWjsLrP, PID: 23028831
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Kawabe T, Kawabe K, Sapru HN. Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus. PLoS One. 2012;7(9):e45180.
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Kawabe, T.1
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14
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84871666264
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Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat
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COI: 1:CAS:528:DC%2BC3sXotVaitg%3D%3D, PID: 23300873
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Kawabe T, Kawabe K, Sapru HN. Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat. PLoS One. 2012;7(12):e53111.
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84880964075
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Tonic gamma-aminobutyric acid-ergic activity in the hypothalamic arcuate nucleus is attenuated in the spontaneously hypertensive rat
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COI: 1:CAS:528:DC%2BC3sXhtFamtr7K, PID: 23774228, This report provides the first documentation that imparied hypothalamic arcuate nucleus signaling contributes to the pathophysiology of hypertension in the spontaneosly hypertensive rat. The impact of arcuate nucleus signaling in other forms of hypertension remains to be established but potentially represents new hypertensive hypothalamic signaling paradigm
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Kawabe T, Kawabe K, Sapru HN. Tonic gamma-aminobutyric acid-ergic activity in the hypothalamic arcuate nucleus is attenuated in the spontaneously hypertensive rat. Hypertension. 2013;62(2):281–7. This report provides the first documentation that imparied hypothalamic arcuate nucleus signaling contributes to the pathophysiology of hypertension in the spontaneosly hypertensive rat. The impact of arcuate nucleus signaling in other forms of hypertension remains to be established but potentially represents new hypertensive hypothalamic signaling paradigm.
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Hypertension
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Kawabe, T.1
Kawabe, K.2
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16
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84872608393
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Renin-angiotensin system modulates neurotransmitters in the paraventricular nucleus and contributes to angiotensin II-induced hypertensive response
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COI: 1:CAS:528:DC%2BC3sXhtFWmsb4%3D, PID: 22971929
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Qi J, Zhang DM, Suo YP, Song XA, Yu XJ, Elks C, et al. Renin-angiotensin system modulates neurotransmitters in the paraventricular nucleus and contributes to angiotensin II-induced hypertensive response. Cardiovasc Toxicol. 2013;13(1):48–54.
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Elks, C.6
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83655184676
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Angiotensin II-induced hypertension is modulated by nuclear factor-kappaB in the paraventricular nucleus
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COI: 1:CAS:528:DC%2BC3MXhs1WksrvJ, PID: 22106405
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Cardinale JP, Sriramula S, Mariappan N, Agarwal D, Francis J. Angiotensin II-induced hypertension is modulated by nuclear factor-kappaB in the paraventricular nucleus. Hypertension. 2012;59(1):113–21.
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Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation
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Sriramula S, Xia H, Xu P, Lazartigues E. Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. Hypertension. 2014. doi:10.1161/HYPERTENSIONAHA.114.04691.
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Sriramula, S.1
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84898057871
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Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension
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COI: 1:CAS:528:DC%2BC2cXksVWrt7g%3D, PID: 24576725
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Su Q, Qin DN, Wang FX, Ren J, Li HB, Zhang M, et al. Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. Toxicol Appl Pharmacol. 2014;276(2):115–20.
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Zhang, M.6
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20
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84875218053
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Early interference with p44/42 mitogen-activated protein kinase signaling in hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension
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COI: 1:CAS:528:DC%2BC3sXktVGntr0%3D, PID: 23438934
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Yu Y, Xue BJ, Zhang ZH, Wei SG, Beltz TG, Guo F, et al. Early interference with p44/42 mitogen-activated protein kinase signaling in hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension. Hypertension. 2013;61(4):842–9.
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Guo, F.6
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21
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84907833438
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Direct pro-inflammatory effects of prorenin on microglia
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Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity
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PID: 23486953
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de Kloet AD, Pati D, Wang L, Hiller H, Sumners C, Frazier CJ, et al. Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity. J Neurosci. 2013;33(11):4825–33.
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84894481809
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Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-alpha
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COI: 1:CAS:528:DC%2BC2cXit1yktL4%3D, PID: 24324037
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Bardgett ME, Holbein WW, Herrera-Rosales M, Toney GM. Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-alpha. Hypertension. 2014;63(3):527–34.
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Toney, G.M.4
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24
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84873454911
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SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats
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COI: 1:CAS:528:DC%2BC3sXhvVyrtb4%3D, PID: 23114721
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Yuan N, Zhang F, Zhang LL, Gao J, Zhou YB, Han Y, et al. SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats. Pflugers Arch. 2013;465(2):261–70.
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25
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84874622902
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Membrane trafficking of NADPH oxidase p47(phox) in paraventricular hypothalamic neurons parallels local free radical production in angiotensin II slow-pressor hypertension
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COI: 1:CAS:528:DC%2BC3sXhtl2jsLjO, PID: 23467347
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Coleman CG, Wang G, Faraco G, Marques Lopes J, Waters EM, Milner TA, et al. Membrane trafficking of NADPH oxidase p47(phox) in paraventricular hypothalamic neurons parallels local free radical production in angiotensin II slow-pressor hypertension. J Neurosci. 2013;33(10):4308–16.
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Waters, E.M.5
Milner, T.A.6
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26
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84861780179
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Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension
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COI: 1:CAS:528:DC%2BC38XhtVGnsb3M, PID: 22447945
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Northcott CA, Billecke S, Craig T, Hinojosa-Laborde C, Patel KP, Chen AF, et al. Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension. Am J Physiol Heart Circ Physiol. 2012;302(11):H2276–84.
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Northcott, C.A.1
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Hinojosa-Laborde, C.4
Patel, K.P.5
Chen, A.F.6
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27
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84892948187
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Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats
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COI: 1:CAS:528:DC%2BC2cXjt1CmtQ%3D%3D, PID: 24218431
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Zhou YB, Sun HJ, Chen D, Liu TY, Han Y, Wang JJ, et al. Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats. Hypertension. 2014;63(2):330–7.
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Zhou, Y.B.1
Sun, H.J.2
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Han, Y.5
Wang, J.J.6
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28
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84876739898
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Arginine vasopressin (AVP) expressional changes in the hypothalamic paraventricular and supraoptic nuclei of stroke-prone spontaneously hypertensive rats
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PID: 22822466
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Yi SS, Kim HJ, Do SG, Lee YB, Ahn HJ, Hwang IK, et al. Arginine vasopressin (AVP) expressional changes in the hypothalamic paraventricular and supraoptic nuclei of stroke-prone spontaneously hypertensive rats. Anat Cell Biol. 2012;45(2):114–20.
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Hwang, I.K.6
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29
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84865314925
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Increased expression of the mineralocorticoid receptor in the brain of spontaneously hypertensive rats
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COI: 1:CAS:528:DC%2BC38Xht1Sktr7I, PID: 22564091
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Pietranera L, Brocca ME, Cymeryng C, Gomez-Sanchez E, Gomez-Sanchez CE, Roig P, et al. Increased expression of the mineralocorticoid receptor in the brain of spontaneously hypertensive rats. J Neuroendocrinol. 2012;24(9):1249–58.
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Cymeryng, C.3
Gomez-Sanchez, E.4
Gomez-Sanchez, C.E.5
Roig, P.6
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30
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84906087416
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Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats
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COI: 1:CAS:528:DC%2BC2cXhtlKjt7jL, PID: 24973408
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Chen A, Huang BS, Wang HW, Ahmad M, Leenen FH. Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats. J Physiol. 2014;592(Pt 16):3523–36.
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J Physiol
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Chen, A.1
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Leenen, F.H.5
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31
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84890435055
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GABAergic excitation of vasopressin neurons: possible mechanism underlying sodium-dependent hypertension
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COI: 1:CAS:528:DC%2BC3sXhvVyisr%2FK, PID: 24103391
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Kim YB, Kim YS, Kim WB, Shen FY, Lee SW, Chung HJ, et al. GABAergic excitation of vasopressin neurons: possible mechanism underlying sodium-dependent hypertension. Circ Res. 2013;113(12):1296–307.
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Chung, H.J.6
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32
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84949324436
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High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons
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COI: 1:CAS:528:DC%2BC2MXhsVeisbc%3D, PID: 25619659, This report reveals a novel action of brain derived neurotrphic factor to downregulate KCC2 to abolish aortic barorecepetor evoked GABAergic inhibition of hypothalamic AVP neurons during sodium challenge. Significantly, this study demonstrates altered GABAergic inputs to hypothalamic AVP neurons drives excess AVP release to evoke hypertension via a peripheral V1 receptor mediated vasoconstrictor mechanism. These studies clearly reveal the impact of excess AVP release on the pathophysiology of salt-sensitive hypertension
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Choe KY, Han SY, Gaub P, Shell B, Voisin DL, Knapp BA, et al. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Neuron. 2015;85(3):549–60. This report reveals a novel action of brain derived neurotrphic factor to downregulate KCC2 to abolish aortic barorecepetor evoked GABAergic inhibition of hypothalamic AVP neurons during sodium challenge. Significantly, this study demonstrates altered GABAergic inputs to hypothalamic AVP neurons drives excess AVP release to evoke hypertension via a peripheral V1 receptor mediated vasoconstrictor mechanism. These studies clearly reveal the impact of excess AVP release on the pathophysiology of salt-sensitive hypertension.
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(2015)
Neuron
, vol.85
, Issue.3
, pp. 549-560
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Choe, K.Y.1
Han, S.Y.2
Gaub, P.3
Shell, B.4
Voisin, D.L.5
Knapp, B.A.6
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33
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84870949675
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Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations
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COI: 1:CAS:528:DC%2BC38XhvVeksr%2FJ, PID: 23124030
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Whelton PK, Appel LJ, Sacco RL, Anderson CA, Antman EM, Campbell N, et al. Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations. Circulation. 2012;126(24):2880–9.
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Antman, E.M.5
Campbell, N.6
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34
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84879378546
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Salt in health and disease—a delicate balance
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COI: 1:CAS:528:DC%2BC3sXlt1Sqs78%3D, PID: 23534562
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Kotchen TA, Cowley Jr AW, Frohlich ED. Salt in health and disease—a delicate balance. New Eng J Med. 2013;368(13):1229–37.
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New Eng J Med
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Kotchen, T.A.1
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35
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84863979009
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Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl rats
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COI: 1:CAS:528:DC%2BC38XhtlOmt7zP
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Huang BS, White RA, Leenen FH. Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl rats. Am J Physiol Reg Integr Comp Physiol. 2012;303(2):R236–45.
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Am J Physiol Reg Integr Comp Physiol
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Holbein WW, Toney GM. Activation of the hypothalamic paraventricular nucleus by forebrain hypertonicity selectively increases tonic vasomotor sympathetic nerve activity. Am J Physiol Reg Integr Comp Physiol. 2014. doi:10.1152/ajpregu.00460.2014.
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Toney, G.M.2
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Dietary salt intake exaggerates sympathetic reflexes and increases blood pressure variability in normotensive rats
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Simmonds SS, Lay J, Stocker SD. Dietary salt intake exaggerates sympathetic reflexes and increases blood pressure variability in normotensive rats. Hypertension. 2014;64(3):583–9.
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Brain heterotrimeric Galphai(2)-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress
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Central nervous system Galphai2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway
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Kapusta DR, Pascale CL, Kuwabara JT, Wainford RD. Central nervous system Galphai2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway. Hypertension. 2013;61(2):368–75.
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Wainford RD, Carmichael CY, Pascale CL, Kuwabara JT. Galphai2-protein-mediated signal transduction: central nervous system molecular mechanism countering the development of sodium-dependent hypertension. Hypertension. 2015;65(1):178–86.
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42
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Central losartan attenuates increases in arterial pressure and expression of FosB/DeltaFosB along the autonomic axis associated with chronic intermittent hypoxia
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Knight WD, Saxena A, Shell B, Nedungadi TP, Mifflin SW, Cunningham JT. Central losartan attenuates increases in arterial pressure and expression of FosB/DeltaFosB along the autonomic axis associated with chronic intermittent hypoxia. Am J Physiol Reg Integr Comp Physiol. 2013;305(9):R1051–8.
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Shell, B.3
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Mifflin, S.W.5
Cunningham, J.T.6
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43
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Chronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus
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COI: 1:CAS:528:DC%2BC2cXltFKhug%3D%3D, PID: 24097432
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Sharpe AL, Calderon AS, Andrade MA, Cunningham JT, Mifflin SW, Toney GM. Chronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus. Am J Physiol Heart Circ Physiol. 2013;305(12):H1772–80.
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Cunningham, J.T.4
Mifflin, S.W.5
Toney, G.M.6
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44
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Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem
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Dergacheva O, Dyavanapalli J, Pinol RA, Mendelowitz D. Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem. Hypertension. 2014;64(3):597–603.
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Mendelowitz, D.4
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45
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Functional and structural changes in the brain associated with the increase in muscle sympathetic nerve activity in obstructive sleep apnoea
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PID: 25379440
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Fatouleh RH, Hammam E, Lundblad LC, Macey PM, McKenzie DK, Henderson LA, et al. Functional and structural changes in the brain associated with the increase in muscle sympathetic nerve activity in obstructive sleep apnoea. NeuroImage Clin. 2014;6:275–83.
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McKenzie, D.K.5
Henderson, L.A.6
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46
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Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation
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COI: 1:CAS:528:DC%2BC3sXjtlCktrg%3D, PID: 23418591
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Tanida M, Yamamoto N, Shibamoto T, Rahmouni K. Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation. PLoS One. 2013;8(2):e56660.
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47
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Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects
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COI: 1:CAS:528:DC%2BC3sXltVelsbo%3D, PID: 23541372, This report demonstrates in obesity-induced hypertension leptin activates mTORC1 via a PI3K pathway and that mTORC1 activity is required to mediate leptin induced increases in renal sympathetic nerve activity and blood pressure. The locus of this action has been identified as the hypothalamic ARCN as ARCN blockade of mTORC1 signaling essentially eliminates leptin evoked hypertension and renal sympathoexcitation
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Harlan SM, Guo DF, Morgan DA, Fernandes-Santos C, Rahmouni K. Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects. Cell Metab. 2013;17(4):599–606. This report demonstrates in obesity-induced hypertension leptin activates mTORC1 via a PI3K pathway and that mTORC1 activity is required to mediate leptin induced increases in renal sympathetic nerve activity and blood pressure. The locus of this action has been identified as the hypothalamic ARCN as ARCN blockade of mTORC1 signaling essentially eliminates leptin evoked hypertension and renal sympathoexcitation.
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(2013)
Cell Metab
, vol.17
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, pp. 599-606
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Harlan, S.M.1
Guo, D.F.2
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Fernandes-Santos, C.4
Rahmouni, K.5
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48
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Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of estrogen
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Shi Z, Brooks VL. Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of estrogen. J Physiol. 2014. doi:10.1113/jphysiol.2014.284638.
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J Physiol
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Shi, Z.1
Brooks, V.L.2
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49
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Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits
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COI: 1:CAS:528:DC%2BC2cXjt1Cmuw%3D%3D, PID: 24191287
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Prior LJ, Davern PJ, Burke SL, Lim K, Armitage JA, Head GA. Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits. Hypertension. 2014;63(2):338–45.
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Lim, K.4
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Head, G.A.6
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50
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Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin
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COI: 1:CAS:528:DC%2BC3sXhtVyjtL3I, PID: 23542919
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Luckett BS, Frielle JL, Wolfgang L, Stocker SD. Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. Am J Physiol Heart Circ Physiol. 2013;304(11):H1538–46.
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Luckett, B.S.1
Frielle, J.L.2
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Stocker, S.D.4
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51
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Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation
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Stocker SD, Gordon KW. Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation. J Neurophysiol. 2014. doi:10.1152/jn.00764.2014.
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J Neurophysiol
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Stocker, S.D.1
Gordon, K.W.2
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52
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84910151414
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Glucocorticoids attenuate the central sympathoexcitatory actions of insulin
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COI: 1:CAS:528:DC%2BC2cXitV2gt7vM, PID: 25185805
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Steiner JL, Bardgett ME, Wolfgang L, Lang CH, Stocker SD. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol. 2014;112(10):2597–604.
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J Neurophysiol
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Steiner, J.L.1
Bardgett, M.E.2
Wolfgang, L.3
Lang, C.H.4
Stocker, S.D.5
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53
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The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight and sympathetic nerve activity in male mice
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PID: 25574706
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Muta K, Morgan DA, Rahmouni K. The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight and sympathetic nerve activity in male mice. Endocrinology. 2015. doi:10.1210/en.2014-1660.
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Endocrinology
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Muta, K.1
Morgan, D.A.2
Rahmouni, K.3
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54
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Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood–brain barrier
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COI: 1:CAS:528:DC%2BC2cXit1yktbg%3D, PID: 24343120, This paper reveals for the first time that circulating Ang II, under hypertensive conditions, exerts direct actions in the brain, specifically in the hypothalamus. These studies reveal in the spontaneously hypertensive rat Ang II impairs the integrity of the blood brain barrier in the hypothalamic region via an AT1R mechanism, facilitating increased Ang II levels and Ang II co-localization with neurons and glial in the PVN
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Biancardi VC, Son SJ, Ahmadi S, Filosa JA, Stern JE. Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood–brain barrier. Hypertension. 2014;63(3):572–9. This paper reveals for the first time that circulating Ang II, under hypertensive conditions, exerts direct actions in the brain, specifically in the hypothalamus. These studies reveal in the spontaneously hypertensive rat Ang II impairs the integrity of the blood brain barrier in the hypothalamic region via an AT1R mechanism, facilitating increased Ang II levels and Ang II co-localization with neurons and glial in the PVN.
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(2014)
Hypertension
, vol.63
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, pp. 572-579
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Biancardi, V.C.1
Son, S.J.2
Ahmadi, S.3
Filosa, J.A.4
Stern, J.E.5
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55
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Sensitization of slow pressor angiotensin II (Ang II)-initiated hypertension: induction of sensitization by prior Ang II treatment
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COI: 1:CAS:528:DC%2BC38Xns1aluw%3D%3D, PID: 22215719, This paper reports the impact of central nervous system sensitization on the pathogenesis of Ang II slow pressor hypertension in which prior sensitization with non-pressor Ang II exacerbates the subsequent hypertensive response to slow pressor Ang II infusion. These data highlight the impact of hypothalamic sensitization on the pathophysiology of hypertension—a phenomenon that may have important implications for the central regulation of blood pressure
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Xue B, Zhang Z, Johnson RF, Johnson AK. Sensitization of slow pressor angiotensin II (Ang II)-initiated hypertension: induction of sensitization by prior Ang II treatment. Hypertension. 2012;59(2):459–66. This paper reports the impact of central nervous system sensitization on the pathogenesis of Ang II slow pressor hypertension in which prior sensitization with non-pressor Ang II exacerbates the subsequent hypertensive response to slow pressor Ang II infusion. These data highlight the impact of hypothalamic sensitization on the pathophysiology of hypertension—a phenomenon that may have important implications for the central regulation of blood pressure.
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(2012)
Hypertension
, vol.59
, Issue.2
, pp. 459-466
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Xue, B.1
Zhang, Z.2
Johnson, R.F.3
Johnson, A.K.4
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56
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Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions
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COI: 1:CAS:528:DC%2BC3sXnsFGlug%3D%3D, PID: 23257356, This publication identifies a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus, which require thyroid hormone signaling for correct development. Significantly, this neuronal population has a profound impact on blood pressure regulation as ablation of these cells evokes hypertension via alteration is central autonomic function. Future studies are required to establish the impact of this neuronal population in the pathophysiology of hypertension
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Mittag J, Lyons DJ, Sallstrom J, Vujovic M, Dudazy-Gralla S, Warner A, et al. Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J Clin Invest. 2013;123(1):509–16. This publication identifies a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus, which require thyroid hormone signaling for correct development. Significantly, this neuronal population has a profound impact on blood pressure regulation as ablation of these cells evokes hypertension via alteration is central autonomic function. Future studies are required to establish the impact of this neuronal population in the pathophysiology of hypertension.
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(2013)
J Clin Invest
, vol.123
, Issue.1
, pp. 509-516
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Mittag, J.1
Lyons, D.J.2
Sallstrom, J.3
Vujovic, M.4
Dudazy-Gralla, S.5
Warner, A.6
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