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Volumn 17, Issue 5, 2015, Pages

Hypothalamic Signaling Mechanisms in Hypertension

Author keywords

Arcuate nucleus; Autonomic control; Hypertension; Hypothalamus; Paraventricular nucleus; Signal transduction

Indexed keywords

ANGIOTENSIN II; VASOPRESSIN DERIVATIVE;

EID: 84928251876     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-015-0550-4     Document Type: Review
Times cited : (62)

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    • COI: 1:CAS:528:DC%2BC2cXit1yktbg%3D, PID: 24343120, This paper reveals for the first time that circulating Ang II, under hypertensive conditions, exerts direct actions in the brain, specifically in the hypothalamus. These studies reveal in the spontaneously hypertensive rat Ang II impairs the integrity of the blood brain barrier in the hypothalamic region via an AT1R mechanism, facilitating increased Ang II levels and Ang II co-localization with neurons and glial in the PVN
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    • Xue B, Zhang Z, Johnson RF, Johnson AK. Sensitization of slow pressor angiotensin II (Ang II)-initiated hypertension: induction of sensitization by prior Ang II treatment. Hypertension. 2012;59(2):459–66. This paper reports the impact of central nervous system sensitization on the pathogenesis of Ang II slow pressor hypertension in which prior sensitization with non-pressor Ang II exacerbates the subsequent hypertensive response to slow pressor Ang II infusion. These data highlight the impact of hypothalamic sensitization on the pathophysiology of hypertension—a phenomenon that may have important implications for the central regulation of blood pressure.
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    • COI: 1:CAS:528:DC%2BC3sXnsFGlug%3D%3D, PID: 23257356, This publication identifies a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus, which require thyroid hormone signaling for correct development. Significantly, this neuronal population has a profound impact on blood pressure regulation as ablation of these cells evokes hypertension via alteration is central autonomic function. Future studies are required to establish the impact of this neuronal population in the pathophysiology of hypertension
    • Mittag J, Lyons DJ, Sallstrom J, Vujovic M, Dudazy-Gralla S, Warner A, et al. Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J Clin Invest. 2013;123(1):509–16. This publication identifies a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus, which require thyroid hormone signaling for correct development. Significantly, this neuronal population has a profound impact on blood pressure regulation as ablation of these cells evokes hypertension via alteration is central autonomic function. Future studies are required to establish the impact of this neuronal population in the pathophysiology of hypertension.
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    • Mittag, J.1    Lyons, D.J.2    Sallstrom, J.3    Vujovic, M.4    Dudazy-Gralla, S.5    Warner, A.6


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