SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats

Pflugers Archiv European Journal of Physiology

Volumn 465, Issue 2, 2013, Pages 261-270

  Yuan, Ning ^a   Zhang, Feng ^a   Zhang, Ling Li ^a   Gao, Juan ^a   Zhou, Ye Bo ^a   Han, Ying ^a   Zhu, Guo Qing ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Gene expression; Hypertension; Paraventricular nucleus; Superoxide dismutase; Sympathetic activity

Indexed keywords

ADENOVIRUS VECTOR; ANGIOTENSIN II; COPPER ZINC SUPEROXIDE DISMUTASE; NORADRENALIN; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; ATTENUATION; COPPER ZINC SUPEROXIDE DISMUTASE GENE; GENE ACTIVITY; GENE OVEREXPRESSION; GENE TRANSFER; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART WEIGHT; MALE; NONHUMAN; NORADRENALIN BLOOD LEVEL; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CONDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC BLOCKING; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE;

ANGIOTENSIN II; ANIMALS; ARTERIES; BLOOD PRESSURE; GENE EXPRESSION; GENE TARGETING; GENETIC VECTORS; HEART VENTRICLES; HUMANS; HYPERTENSION; MALE; MYOCYTES, CARDIAC; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, INBRED SHR; RATS, WISTAR; SUPEROXIDE DISMUTASE; SUPEROXIDES; SYMPATHETIC NERVOUS SYSTEM; UP-REGULATION;

EID: 84873454911     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1173-0     Document Type: Article

References (47)

1. Bagnost T, Ma L, da Silva RF, Rezakhaniha R, Houdayer C, Stergiopulos N, Andre C, Guillaume Y, Berthelot A, Demougeot C (2010) Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension. Cardiovasc Res 87:569-577
2. Bell D, Kelso EJ, Argent CC, Lee GR, Allen AR, McDermott BJ (2004) Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat. Cardiovasc Pathol 13:71-78
3. Benarroch EE (2005) Paraventricular nucleus, stress response, and cardiovascular disease. Clin Auton Res 15:254-263
4. Burns J, Sivananthan MU, Ball SG, Mackintosh AF, Mary DA, Greenwood JP (2007) Relationship between central sympathetic drive and magnetic resonance imaging-determined left ventricular mass in essential hypertension. Circulation 115:1999-2005
5. Cassis P, Conti S, Remuzzi G, Benigni A (2010) Angiotensin receptors as determinants of life span. Pflugers Arch 459:325-332
6. 1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats. Exp Physiol 96:94-103
7. Ciriello J, Kline RL, Zhang TX, Caverson MM (1984) Lesions of the paraventricular nucleus alter the development of spontaneous hypertension in the rat. Brain Res 310:355-359
8. Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ (1993) A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 3:219-223
9. Ding Y, Li YL, Zimmerman MC, Davisson RL, Schultz HD (2009) Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits. Cardiovasc Res 81:678-685
10. Du YH, Chen AF (2007) A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes. J Appl Physiol 102:9-10
11. Duan YC, Xu B, Shi Z, Gao J, Zhang SJ, Wang W, Chen Q, Zhu GQ (2009) Nucleus of solitary tract mediates cardiac sympathetic afferent reflex in rats. Pflugers Arch 459:1-9
12. Dumasius V, Jameel M, Burhop J, Meng FJ, Welch LC, Mutlu GG, Factor P (2003) In vivo timing of onset of transgene expression following adenoviral-mediated gene transfer. Virology 308:243-249
13. Esler M, Lambert E, Schlaich M (2010) Point: chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension. J Appl Physiol 109:1996-1998
14. Fan ZD, Zhang L, Shi Z, Gan XB, Gao XY, Zhu GQ (2012) Artificial microRNA interference targeting AT1a receptors in paraventricular nucleus attenuates hypertension in rats. Gene Ther 19:810-817
15. Fisher JP, Fadel PJ (2010) Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension. Exp Physiol 95:572-580
16. Fujimoto H, Taguchi J, Imai Y, Ayabe S, Hashimoto H, Kobayashi H, Ogasawara K, Aizawa T, Yamakado M, Nagai R, Ohno M (2008) Manganese superoxide dismutase polymorphism affects the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery disease. Eur Heart J 29:1267-1274
17. Fujita M, Ando K, Nagae A, Fujita T (2007) Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in salt-sensitive hypertension. Hypertension 50:360-367
18. Fukai T, Ushio-Fukai M (2011) Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 15:1583-1606
19. Gao J, Zhong MK, Fan ZD, Yuan N, Zhou YB, Zhang F, Gao XY, Zhu GQ (2012) SOD1 overexpression in paraventricular nucleus improves post-infarct myocardial remodeling and ventricular function. Pflugers Arch 463:297-307
20. Gao L, Wang W, Liu D, Zucker IH (2007) Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure. Circulation 115:3095-3102
21. Goldstein DS (1983) Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5:86-99
22. Graham D, McBride MW, Brain NJ, Dominiczak AF (2005) Congenic/consomic models of hypertension. Methods Mol Med 108:3-15
23. Grassi G, Seravalle G, Quarti-Trevano F (2010) The 'neuroadrenergic hypothesis' in hypertension: current evidence. Exp Physiol 95:581-586
24. Guo ZL, Moazzami AR (2004) Involvement of nuclei in the hypothalamus in cardiac sympathoexcitatory reflexes in cats. Brain Res 1006:36-48
25. Han Y, Fan ZD, Yuan N, Xie GQ, Gao J, De W, Gao XY, Zhu GQ (2011) Superoxide anions in paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity in renovascular hypertensive rats. J Appl Physiol 110:646-652
26. Han Y, Yuan N, Zhang SJ, Gao J, Shi Z, Zhou YB, Gao XY, Zhu GQ (2011) c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. Pflugers Arch 461:437-446
27. Intengan HD, Schiffrin EL (2001) Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38:581-587
28. Levick SP, Murray DB, Janicki JS, Brower GL (2010) Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart. Hypertension 55:270-276
29. Li DP, Pan HL (2007) Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension. Hypertension 49:916-925
30. Malliani A, Montano N (2002) Emerging excitatory role of cardiovascular sympathetic afferents in pathophysiological conditions. Hypertension 39:63-68
31. Mancia G, Grassi G, Giannattasio C, Seravalle G (1999) Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension 34:724-728
32. Messerli FH, Williams B, Ritz E (2007) Essential hypertension. Lancet 370:591-603
33. Miller AF (2012) Superoxide dismutases: ancient enzymes and new insights. FEBS Lett 586:585-595
34. Mischel NA, Mueller PJ (2011) (In)activity-dependent alterations in resting and reflex control of splanchnic sympathetic nerve activity. J Appl Physiol 111:1854-1862
35. Nagae A, Fujita M, Kawarazaki H, Matsui H, Ando K, Fujita T (2009) Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension. Circulation 119:978-986
36. Preuss HG, Echard B, Bagchi D, Perricone NV (2010) Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats. Int J Med Sci 7:169-180
37. Savage DD, Garrison RJ, Kannel WB, Levy D, Anderson SJ, Stokes J III, Feinleib M, Castelli WP (1987) The spectrum of left ventricular hypertrophy in a general population sample: the Framingham Study. Circulation 75:I26-I33
38. Shi Z, Chen AD, Xu Y, Chen Q, Gao XY, Wang W, Zhu GQ (2009) Long-term administration of tempol attenuates postinfarct ventricular dysfunction and sympathetic activity in rats. Pflugers Arch 458:247-257
39. Shi Z, Chen WW, Xiong XQ, Han Y, Zhou YB, Zhang F, Gao XY, Zhu GQ (2012) Sympathetic activation by chemical stimulation of white adipose tissues in rats. J Appl Physiol 112:1008-1014
40. Smith SH, Bishop SP (1986) Selection criteria for drug-treated animals in two-kidney, one clip renal hypertension. Hypertension 8:700-705
41. Takeda K, Nakata T, Takesako T, Itoh H, Hirata M, Kawasaki S, Hayashi J, Oguro M, Sasaki S, Nakagawa M (1991) Sympathetic inhibition and attenuation of spontaneous hypertension by PVN lesions in rats. Brain Res 543:296-300
42. Toscano MG, Romero Z, Munoz P, Cobo M, Benabdellah K, Martin F (2011) Physiological and tissue-specific vectors for treatment of inherited diseases. Gene Ther 18:117-127
43. Xiong XQ, Chen WW, Han Y, Zhou YB, Zhang F, Gao XY, Zhu GQ (2012) Enhanced adipose afferent reflex contributes to sympathetic activation in diet-induced obesity hypertension. Hypertension 60:1280-1286
44. Yu Y, Zhong MK, Li J, Sun XL, Xie GQ, Wang W, Zhu GQ (2007) Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Arch 454:551-557
45. Zhong MK, Duan YC, Chen AD, Xu B, Gao XY, De W, Zhu GQ (2008) Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats. Exp Physiol 93:746-753
46. Zhou LM, Shi Z, Gao J, Han Y, Yuan N, Gao XY, Zhu GQ (2010) Angiotensin-(1-7) and angiotensin II in the rostral ventrolateral medulla modulate the cardiac sympathetic afferent reflex and sympathetic activity in rats. Pflugers Arch 459:681-688
47. Zhu GQ, Xu Y, Zhou LM, Li YH, Fan LM, Wang W, Gao XY, Chen Q (2009) Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats. Exp Physiol 94:785-794