Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats

Journal of Physiology

Volumn 592, Issue 16, 2014, Pages 3523-3536

  Chen, Aidong ^a   Huang, Bing S ^a   Wang, Hong Wei ^a   Ahmad, Monir ^a   Leenen, Frans H H ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PARVOVIRUS VECTOR; SMALL INTERFERING RNA; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HYPERTENSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MEAN ARTERIAL PRESSURE; NERVE PROJECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR SENSITIVITY; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBFORNICAL ORGAN; SUPRAOPTIC NUCLEUS; WESTERN BLOTTING; WISTAR RAT; ANIMAL; GENETICS; METABOLISM;

ANGIOTENSIN II; ANIMALS; HYPERTENSION; MALE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, MINERALOCORTICOID;

EID: 84906087416     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.275560     Document Type: Article

References (46)

1. Amin MS, Wang HW, Reza E, Whitman SC, Tuana BS & Leenen FHH (2005). Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain. Am J Physiol Heart Circ Physiol 289, R1787-H1797.
2. Bains JS, Potyok A & Ferguson AV (1992). Angiotensin II actions in paraventricular nucleus: functional evidence for neurotransmitter role in efferents originating in subfornical organ. Brain Res 599, 223-229.
3. Biancardi VC, Son SJ, Ahmadi S, Filosa JA & Stern JE (2014). Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier. Hypertension 63, 572-579.
4. Cao X, Peterson JR, Wang G, Anrather J, Young CN, Guruju MR, Burmeister MA, Iadecola C & Davisson RL (2012). Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signalling in the subfornical organ of the brain. Hypertension 59, 869-876.
5. Chiu AT, Dunscomb J, Kosierowski J, Burton CR, Santomenna LD, Corjay MH & Benfield P (1993). The ligand binding signatures of the rat AT1a, AT1b and the human AT1 receptors are essentially identical. Biochem Biophys Res Commun 197, 440-449.
6. Collister JP & Hendel MD (2005). Chronic effects of angiotensin II and AT1 receptor antagonists in subfornical organ-lesioned rats. Clin Exp Pharmacol Physiol 32, 462-466.
7. Davern PJ & Head GA (2007). Fos-related antigen immunoreactivity after acute and chronic angiotensin II-induced hypertension in the rabbit brain. Hypertension 49, 1170-1177.
8. de Backer MWA, Brans MAD, Luijendijk MC, Garner KM & Adan RAH (2010). Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus. Hum Gene Ther 21, 673-682.
9. Ferguson AV (2009). Angiotensinergic regulation of autonomic and neuroendocrine outputs: critical roles for the subfornical organ and paraventricular nucleus. Neuroendocrinology 89, 370-376.
10. Fink GD (1997). Long-term sympatho-excitatory effect of angiotensin II: a mechanism of spontaneous and renovascular hypertension. Clin Exp Pharmacol Physiol 24, 91-95.
11. Füchtbauer L, Groth-Rasmussen M, Holm TH, Løbner M, Toft-Hansen H, Khorooshi R & Owens T (2011). Angiotensin II Type 1 receptor (AT1) signalling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system. Brain Behav Immun 25, 897-904.
12. Gabor A & Leenen FHH (2012). Central neuromodulatory pathways regulating sympathetic activity in hypertension. J Appl Physiol 113, 1294-1303.
13. Gabor A & Leenen FHH (2013). Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension. Hypertension 61, 1083-1090.
14. Hellal-Levy C, Fagart J, Souque A, Rafestin-Oblin ME (2000). Mechanistic aspects of mineralocorticoid receptor activation. Kidney Int 57, 1250-1255.
15. Huang BS, Ahmadi S, Ahmad M, White RA & Leenen FH (2010). Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-'ouabain' pathway. Am J Physiol Heart Circ Physiol 299, H422-H430.
16. Huang BS, Ahmad M, Chen A, White RA & Leenen FHH (2013a). Aldosterone-salt hypertension depends on the SFO, central aldosterone synthase and MR specifically in the PVN. Hypertension 62, A441 (abstract).
17. Huang BS, White RA, Ahmad M & Leenen FHH (2013b). Role of brain corticosterone and aldosterone in central angiotensin II- induced hypertension. Hypertension 62, 564-571.
18. Huang BS, Zheng H, Tan J, Patel KP & Leenen FH (2011). Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone. Exp Physiol 96, 1028-1038.
19. Hwang IK, Yoo KY, Nam YS, Choi JH, Lee IS, Kwon YG, Kang TC, Kim YS & Won MH (2006). Mineralocorticoid and glucocorticoid receptor expressions in astrocytes and microglia in the gerbil hippocampal CA1 region after ischemic insult. Neurosci Res 54, 319-327.
20. Jaffe IZ & Mendelsohn ME (2005). Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ Res 96, 643-650.
21. Jöhren O & Saavedra JM (1996). Expression of AT1A and AT1B angiotensin II receptor messenger RNA in forebrain of 2-wk-old rats. Am J Physiol Endocrinol Metab 271, E104-E112.
22. Keen-Rhinehart E, Kalra SP & Kalra PS (2005). AAV-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats. Peptides 26, 2567-2578.
23. King AJ & Fink GD (2006). Chronic low-dose angiotensin II infusion increases venomotor tone by neurogenic mechanisms. Hypertension 48, 927-933.
24. Ku YH, Jia YF & Chang YZ (1999). Mechanisms underlying pressor response of subfornical organ to angiotensin II. Peptides 20, 171-176.
25. Lenkei Z, Palkovits M, Corvol P, Llorens-Cortes C (1998). Distribution of angiotensin type-1 receptor messenger RNA expression in the adult rat brain. Neuroscience 82, 827-841.
26. Li W, Peng H, Mehaffey EP, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A & Feng Y (2014). Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension. Hypertension 63, 316-323.
27. Li Q, Dale WE, Hasser EM & Blaine EH (1996). Acute and chronic angiotensin hypertension: neural and nonneural components, time course, and dose dependency. Am J Physiol 271, R200-R207.
28. Lob HE, Schultz D, Marvar PJ, Davisson RL & Harrison DG (2013). Role of the NADPH oxidases in the subfornical organ in angiotensin II-induced hypertension. Hypertension 61, 382-387.
29. Meijer OC (2002). Coregulator proteins and corticosteroid action in the brain. J Neuroendocrinol 14, 499-505.
30. Oldfield BJ, Davern PJ, Giles ME, Allen AM, Badoer E & McKinley MJ (2001). Efferent neural projections of angiotensin receptor (AT1) expressing neurones in the hypothalamic paraventricular nucleus of the rat. J Neuroendocrinol 13, 139-146.
31. Rautureaua Y, Paradisa P & Schiffrin EL (2011). Cross-talk between aldosterone and angiotensin signalling in vascular smooth muscle cells. Steroids 76, 834-839.
32. Sriramula S, Cardinale JP, Lazartigues E & Francis J (2011). ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovasc Res 92, 401-408.
33. 1aR) by RNA interference. Hypertension 45, 115-119.
34. Veltmar A, Culman J, Qadri F, Rascher W & Unger T (1984). Involvement of adrenergic and angiotensinergic receptors in the paraventricular nucleus in the angiotensin II-induced vasopressin release. J Pharmacol Exp Ther 263, 1253-1260.
35. Vieira AA, Nahey DB & Collister JP (2010). Role of the organum vasculosum of the lamina terminalis for the chronic cardiovascular effects produced by endogenous and exogenous ANG II in conscious rats. Am J Physiol Regul Integ Comp Physiol 299, R1564-R1571.
36. Wang HW, Amin MS, El-Shahat E, Huang BS, Tuana BS & Leenen FHH (2010). Effects of central sodium on epithelial sodium channels in rat brain. Am J Physiol Regul Integ Comp Physiol 299, R222-R233.
37. Wang X, Skelley L, Cade R & Sun Z (2006). AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage. Gene Ther 13, 1097-1103.
38. Wei SG, Yu Y, Zhang ZH & Felder RB (2009). Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway. Am J Physiol Heart Circ Physiol 296, H1425-H1433.
39. Wright JW, Roberts KA, Stubley LA, Hanesworth JM & Harding JW (1993). Hypothalamic angiotensin release in response to AII or glutamic acid stimulation of the SFO in rats. Brain Res Bull 31, 649-654.
40. Xue B, Beltz TG, Johnson RF, Guo F, Hay M & Johnson AK (2012a). PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice. Am J Physiol Heart Circ Physiol 302, H733-H741.
41. Xue B, Beltz TG, Yu Y, Guo F, Gomez-Sanchez CE, Hay M & Johnson AK (2011). Central interactions of aldosterone and angiotensin II in aldosterone- and angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol 300, H555-H564.
42. Xue B, Zhang Z, Roncari CF, Guo F & Johnson AK (2012). Aldosterone acting through the central nervous system sensitizes angiotensin II-induced hypertension. Hypertension 60, 1023-1030.
43. Yoshika M, Komiyama Y & Takahashi H (2011). An ouabain-like factor is secreted from immortalized hypothalamic cells in an aldosterone-dependent manner. Neurochem Int 59, 104-108.
44. Yu Y, Xue BJ, Zhang ZH, Wei SG, Beltz TG, Guo F, Johnson AK & Felder RB (2013). Early interference with p44/42 mitogen-activated protein kinase signalling in hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension. Hypertension 61, 842-849.
45. Zhang ZH, Yu Y, Kang YM, Wei SG & Felder RB (2008). Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. Am J Physiol Heart Circ Physiol 294, H1067-H1074.
46. Zimmerman MC, Lazartigues E, Sharma RV & Davisson RL (2004). Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res 95, 210-216.