메뉴 건너뛰기




Volumn 9, Issue MAR, 2015, Pages

Living without insulin: The role of leptin signaling in the hypothalamus

Author keywords

Central nervous system; Diabetes mellitus; Diabetes mellitus type 1; Diabetes mellitus type 2; Insulin; Leptin; Leptin receptors

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ALPHA INTERMEDIN; GLUCAGON; GLUCOSE; INSULIN; LEPTIN; MELANOCORTIN RECEPTOR; MUSCARINIC RECEPTOR;

EID: 84928164899     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2015.00108     Document Type: Article
Times cited : (21)

References (85)
  • 1
    • 84893434815 scopus 로고    scopus 로고
    • Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
    • Balland, E., Dam, J., Langlet, F., Caron, E., Steculorum, S., Messina, A., et al. (2014). Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab. 19, 293-301. doi: 10.1016/j.cmet.2013.12.015
    • (2014) Cell Metab. , vol.19 , pp. 293-301
    • Balland, E.1    Dam, J.2    Langlet, F.3    Caron, E.4    Steculorum, S.5    Messina, A.6
  • 2
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    • Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., et al. (2004). Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983-991. doi: 10.1016/j.neuron.2004.06.004
    • (2004) Neuron , vol.42 , pp. 983-991
    • Balthasar, N.1    Coppari, R.2    McMinn, J.3    Liu, S.M.4    Lee, C.E.5    Tang, V.6
  • 3
    • 27544450765 scopus 로고    scopus 로고
    • Divergence of melanocortin pathways in the control of food intake and energy expenditure
    • Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J., Funahashi, H., Williams, T., et al. (2005). Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123, 493-505. doi: 10.1016/j.cell.2005.08.035
    • (2005) Cell , vol.123 , pp. 493-505
    • Balthasar, N.1    Dalgaard, L.T.2    Lee, C.E.3    Yu, J.4    Funahashi, H.5    Williams, T.6
  • 4
    • 0031439778 scopus 로고    scopus 로고
    • Leptin selectively decreases visceral adiposity and enhances insulin action
    • Barzilai, N., Wang, J., Massilon, D., Vuguin, P., Hawkins, M., and Rossetti, L. (1997). Leptin selectively decreases visceral adiposity and enhances insulin action. J. Clin. Invest. 100, 3105-3110. doi: 10.1172/JCI119865
    • (1997) J. Clin. Invest. , vol.100 , pp. 3105-3110
    • Barzilai, N.1    Wang, J.2    Massilon, D.3    Vuguin, P.4    Hawkins, M.5    Rossetti, L.6
  • 5
    • 84863267488 scopus 로고    scopus 로고
    • Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
    • Berglund, E. D., Vianna, C. R., Donato, J. Jr. Kim, M. H., Chuang, J. C., Lee, C. E., et al. (2012). Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J. Clin. Invest. 122, 1000-1009. doi: 10.1172/JCI59816
    • (2012) J. Clin. Invest. , vol.122 , pp. 1000-1009
    • Berglund, E.D.1    Vianna, C.R.2    Donato, J.3    Kim, M.H.4    Chuang, J.C.5    Lee, C.E.6
  • 6
    • 0017902736 scopus 로고
    • Certain pharmacological characteristics of the release of pancreatic glucagon in response to stimulation of the splanchnic nerves
    • Bloom, S. R., and Edwards, A. V. (1978). Certain pharmacological characteristics of the release of pancreatic glucagon in response to stimulation of the splanchnic nerves. J. Physiol. 280, 25-35. doi: 10.1113/jphysiol.1978.sp012370
    • (1978) J. Physiol. , vol.280 , pp. 25-35
    • Bloom, S.R.1    Edwards, A.V.2
  • 7
    • 0015949587 scopus 로고
    • The role of the autonomic innervation in the control of glucagon release during hypoglycaemia in the calf
    • Bloom, S. R., Edwards, A. V., and Vaughan, N. J. (1974). The role of the autonomic innervation in the control of glucagon release during hypoglycaemia in the calf. J. Physiol. 236, 611-623. doi: 10.1113/jphysiol.1974.sp010455
    • (1974) J. Physiol. , vol.236 , pp. 611-623
    • Bloom, S.R.1    Edwards, A.V.2    Vaughan, N.J.3
  • 8
    • 84873162774 scopus 로고    scopus 로고
    • Hypothalamic tanycytes: potential roles in the control of feeding and energy balance
    • Bolborea, M., and Dale, N. (2013). Hypothalamic tanycytes: potential roles in the control of feeding and energy balance. Trends Neurosci. 36, 91-100. doi: 10.1016/j.tins.2012.12.008
    • (2013) Trends Neurosci. , vol.36 , pp. 91-100
    • Bolborea, M.1    Dale, N.2
  • 9
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    • Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., et al. (1996). Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-495. doi: 10.1016/S0092-8674(00)81294-5
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6
  • 10
    • 0033037727 scopus 로고    scopus 로고
    • Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat
    • Chinookoswong, N., Wang, J. L., and Shi, Z. Q. (1999). Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes 48, 1487-1492. doi: 10.2337/diabetes.48.7.1487
    • (1999) Diabetes , vol.48 , pp. 1487-1492
    • Chinookoswong, N.1    Wang, J.L.2    Shi, Z.Q.3
  • 11
    • 33845572889 scopus 로고    scopus 로고
    • Studies on the physiological functions of the melanocortin system
    • Cone, R. D. (2006). Studies on the physiological functions of the melanocortin system. Endocr. Rev. 27, 736-749. doi: 10.1210/er.2006-0034
    • (2006) Endocr. Rev. , vol.27 , pp. 736-749
    • Cone, R.D.1
  • 12
    • 84866076374 scopus 로고    scopus 로고
    • Leptin revisited: its mechanism of action and potential for treating diabetes
    • Coppari, R., and Bjorbaek, C. (2012). Leptin revisited: its mechanism of action and potential for treating diabetes. Nat. Rev. Drug Discov. 11, 692-708. doi: 10.1038/nrd3757
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 692-708
    • Coppari, R.1    Bjorbaek, C.2
  • 13
    • 17844389670 scopus 로고    scopus 로고
    • The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    • Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., et al. (2005). The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 1, 63-72. doi: 10.1016/j.cmet.2004.12.004
    • (2005) Cell Metab. , vol.1 , pp. 63-72
    • Coppari, R.1    Ichinose, M.2    Lee, C.E.3    Pullen, A.E.4    Kenny, C.D.5    McGovern, R.A.6
  • 14
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., et al. (2009). Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517. doi: 10.1056/NEJMoa0810780
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3    Tal, I.4    Rodman, D.5    Goldfine, A.B.6
  • 15
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., et al. (2006). Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49, 191-203. doi: 10.1016/j.neuron.2005.12.021
    • (2006) Neuron , vol.49 , pp. 191-203
    • Dhillon, H.1    Zigman, J.M.2    Ye, C.3    Lee, C.E.4    McGovern, R.A.5    Tang, V.6
  • 16
    • 84907968471 scopus 로고    scopus 로고
    • The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus
    • Dodd, G. T., Worth, A. A., Nunn, N., Korpal, A. K., Bechtold, D. A., Allison, M. B., et al. (2014). The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 20, 639-649. doi: 10.1016/j.cmet.2014.07.022
    • (2014) Cell Metab. , vol.20 , pp. 639-649
    • Dodd, G.T.1    Worth, A.A.2    Nunn, N.3    Korpal, A.K.4    Bechtold, D.A.5    Allison, M.B.6
  • 17
    • 0033525879 scopus 로고    scopus 로고
    • alpha-adrenergic stimulation mediates glucose uptake through phosphatidylinositol 3-kinase in rat heart
    • Doenst, T., and Taegtmeyer, H. (1999). alpha-adrenergic stimulation mediates glucose uptake through phosphatidylinositol 3-kinase in rat heart. Circ. Res. 84, 467-474. doi: 10.1161/01.RES.84.4.467
    • (1999) Circ. Res. , vol.84 , pp. 467-474
    • Doenst, T.1    Taegtmeyer, H.2
  • 18
    • 0031906674 scopus 로고    scopus 로고
    • Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
    • Elmquist, J. K., Ahima, R. S., Elias, C. F., Flier, J. S., and Saper, C. B. (1998). Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc. Natl. Acad. Sci. U.S.A. 95, 741-746. doi: 10.1073/pnas.95.2.741
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 741-746
    • Elmquist, J.K.1    Ahima, R.S.2    Elias, C.F.3    Flier, J.S.4    Saper, C.B.5
  • 19
    • 80052156758 scopus 로고    scopus 로고
    • Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
    • Enriori, P. J., Sinnayah, P., Simonds, S. E., Garcia Rudaz, C., and Cowley, M. A. (2011). Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J. Neurosci. 31, 12189-12197. doi: 10.1523/JNEUROSCI.2336-11.2011
    • (2011) J. Neurosci. , vol.31
    • Enriori, P.J.1    Sinnayah, P.2    Simonds, S.E.3    Garcia Rudaz, C.4    Cowley, M.A.5
  • 21
    • 84883483789 scopus 로고    scopus 로고
    • Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
    • Fujikawa, T., Berglund, E. D., Patel, V. R., Ramadori, G., Vianna, C. R., Vong, L., et al. (2013). Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 18, 431-444. doi: 10.1016/j.cmet.2013.08.004
    • (2013) Cell Metab. , vol.18 , pp. 431-444
    • Fujikawa, T.1    Berglund, E.D.2    Patel, V.R.3    Ramadori, G.4    Vianna, C.R.5    Vong, L.6
  • 22
    • 78049271280 scopus 로고    scopus 로고
    • Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
    • Fujikawa, T., Chuang, J. C., Sakata, I., Ramadori, G., and Coppari, R. (2010). Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc. Natl. Acad. Sci. U.S.A. 107, 17391-17396. doi: 10.1073/pnas.1008025107
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 17391-17396
    • Fujikawa, T.1    Chuang, J.C.2    Sakata, I.3    Ramadori, G.4    Coppari, R.5
  • 24
    • 79957896666 scopus 로고    scopus 로고
    • Sixteen years and counting: an update on leptin in energy balance
    • Gautron, L., and Elmquist, J. K. (2011). Sixteen years and counting: an update on leptin in energy balance. J. Clin. Invest. 121, 2087-2093. doi: 10.1172/JCI45888
    • (2011) J. Clin. Invest. , vol.121 , pp. 2087-2093
    • Gautron, L.1    Elmquist, J.K.2
  • 25
    • 70349337472 scopus 로고    scopus 로고
    • Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
    • German, J., Kim, F., Schwartz, G. J., Havel, P. J., Rhodes, C. J., Schwartz, M. W., et al. (2009). Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology 150, 4502-4511. doi: 10.1210/en.2009-0445
    • (2009) Endocrinology , vol.150 , pp. 4502-4511
    • German, J.1    Kim, F.2    Schwartz, G.J.3    Havel, P.J.4    Rhodes, C.J.5    Schwartz, M.W.6
  • 26
    • 84901281450 scopus 로고    scopus 로고
    • Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions
    • Goncalves, G. H., Li, W., Garcia, A. V., Figueiredo, M. S., and Bjorbaek, C. (2014). Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions. Cell Rep. 7, 1093-1103. doi: 10.1016/j.celrep.2014.04.010
    • (2014) Cell Rep. , vol.7 , pp. 1093-1103
    • Goncalves, G.H.1    Li, W.2    Garcia, A.V.3    Figueiredo, M.S.4    Bjorbaek, C.5
  • 27
    • 84857408775 scopus 로고    scopus 로고
    • Reversal of type 1 diabetes in mice by brown adipose tissue transplant
    • Gunawardana, S. C., and Piston, D. W. (2012). Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 61, 674-682. doi: 10.2337/db11-0510
    • (2012) Diabetes , vol.61 , pp. 674-682
    • Gunawardana, S.C.1    Piston, D.W.2
  • 28
    • 0032830174 scopus 로고    scopus 로고
    • Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats
    • Haque, M. S., Minokoshi, Y., Hamai, M., Iwai, M., Horiuchi, M., and Shimazu, T. (1999). Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats. Diabetes 48, 1706-1712. doi: 10.2337/diabetes.48.9.1706
    • (1999) Diabetes , vol.48 , pp. 1706-1712
    • Haque, M.S.1    Minokoshi, Y.2    Hamai, M.3    Iwai, M.4    Horiuchi, M.5    Shimazu, T.6
  • 29
    • 18344374382 scopus 로고    scopus 로고
    • Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats
    • Hidaka, S., Yoshimatsu, H., Kondou, S., Tsuruta, Y., Oka, K., Noguchi, H., et al. (2002). Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J. 16, 509-518. doi: 10.1096/fj.01-0164com
    • (2002) FASEB J. , vol.16 , pp. 509-518
    • Hidaka, S.1    Yoshimatsu, H.2    Kondou, S.3    Tsuruta, Y.4    Oka, K.5    Noguchi, H.6
  • 30
    • 77950264425 scopus 로고    scopus 로고
    • Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    • Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., et al. (2010). Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 11, 286-297. doi: 10.1016/j.cmet.2010.03.002
    • (2010) Cell Metab. , vol.11 , pp. 286-297
    • Hill, J.W.1    Elias, C.F.2    Fukuda, M.3    Williams, K.W.4    Berglund, E.D.5    Holland, W.L.6
  • 31
    • 70350317881 scopus 로고    scopus 로고
    • Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis
    • Hill, J. W., Xu, Y., Preitner, F., Fukuda, M., Cho, Y. R., Luo, J., et al. (2009). Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology 150, 4874-4882. doi: 10.1210/en.2009-0454
    • (2009) Endocrinology , vol.150 , pp. 4874-4882
    • Hill, J.W.1    Xu, Y.2    Preitner, F.3    Fukuda, M.4    Cho, Y.R.5    Luo, J.6
  • 32
    • 66049133685 scopus 로고    scopus 로고
    • Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
    • Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X. H., et al. (2009). Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab. 9, 537-547. doi: 10.1016/j.cmet.2009.05.003
    • (2009) Cell Metab. , vol.9 , pp. 537-547
    • Huo, L.1    Gamber, K.2    Greeley, S.3    Silva, J.4    Huntoon, N.5    Leng, X.H.6
  • 33
    • 17044452545 scopus 로고
    • Paraventricular nucleus modulation of glycemia and insulinemia in freely moving lean rats
    • Ionescu, E., Coimbra, C. C., Walker, C. D., and Jeanrenaud, B. (1989). Paraventricular nucleus modulation of glycemia and insulinemia in freely moving lean rats. Am. J. Physiol. 257, R1370-R1376.
    • (1989) Am. J. Physiol. , vol.257 , pp. R1370-R1376
    • Ionescu, E.1    Coimbra, C.C.2    Walker, C.D.3    Jeanrenaud, B.4
  • 34
    • 33748757323 scopus 로고    scopus 로고
    • Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids
    • Jamieson, P. M., Li, C., Kukura, C., Vaughan, J., and Vale, W. (2006). Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids. Endocrinology 147, 4578-4588. doi: 10.1210/en.2006-0545
    • (2006) Endocrinology , vol.147 , pp. 4578-4588
    • Jamieson, P.M.1    Li, C.2    Kukura, C.3    Vaughan, J.4    Vale, W.5
  • 35
    • 0030847432 scopus 로고    scopus 로고
    • Acute stimulation of glucose metabolism in mice by leptin treatment
    • Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M., and Charron, M. J. (1997). Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389, 374-377. doi: 10.1038/38717
    • (1997) Nature , vol.389 , pp. 374-377
    • Kamohara, S.1    Burcelin, R.2    Halaas, J.L.3    Friedman, J.M.4    Charron, M.J.5
  • 36
    • 0016287768 scopus 로고
    • Effects of vagal stimulation on glucagon and insulin secretion
    • Kaneto, A., Miki, E., and Kosaka, K. (1974). Effects of vagal stimulation on glucagon and insulin secretion. Endocrinology 95, 1005-1010. doi: 10.1210/endo-95-4-1005
    • (1974) Endocrinology , vol.95 , pp. 1005-1010
    • Kaneto, A.1    Miki, E.2    Kosaka, K.3
  • 37
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon, C. J. (2010). The genetics of ageing. Nature 464, 504-512. doi: 10.1038/nature08980
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 38
    • 33746537247 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    • Kievit, P., Howard, J. K., Badman, M. K., Balthasar, N., Coppari, R., Mori, H., et al. (2006). Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 4, 123-132. doi: 10.1016/j.cmet.2006.06.010
    • (2006) Cell Metab. , vol.4 , pp. 123-132
    • Kievit, P.1    Howard, J.K.2    Badman, M.K.3    Balthasar, N.4    Coppari, R.5    Mori, H.6
  • 39
    • 84903382613 scopus 로고    scopus 로고
    • Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
    • Kim, J. G., Suyama, S., Koch, M., Jin, S., Argente-Arizon, P., Argente, J., et al. (2014). Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat. Neurosci. 17, 908-910. doi: 10.1038/nn.3725
    • (2014) Nat. Neurosci. , vol.17 , pp. 908-910
    • Kim, J.G.1    Suyama, S.2    Koch, M.3    Jin, S.4    Argente-Arizon, P.5    Argente, J.6
  • 40
    • 65249162834 scopus 로고    scopus 로고
    • Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver
    • Klieverik, L. P., Janssen, S. F., van Riel, A., Foppen, E., Bisschop, P. H., Serlie, M. J., et al. (2009). Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc. Natl. Acad. Sci. U.S.A. 106, 5966-5971. doi: 10.1073/pnas.0805355106
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 5966-5971
    • Klieverik, L.P.1    Janssen, S.F.2    van Riel, A.3    Foppen, E.4    Bisschop, P.H.5    Serlie, M.J.6
  • 41
    • 84868012864 scopus 로고    scopus 로고
    • GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure
    • Kong, D., Tong, Q., Ye, C., Koda, S., Fuller, P. M., Krashes, M. J., et al. (2012). GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 151, 645-657. doi: 10.1016/j.cell.2012.09.020
    • (2012) Cell , vol.151 , pp. 645-657
    • Kong, D.1    Tong, Q.2    Ye, C.3    Koda, S.4    Fuller, P.M.5    Krashes, M.J.6
  • 42
    • 0025802636 scopus 로고
    • Involvement of hypothalamic serotonin in activation of the sympathoadrenomedullary system and hypothalamo-pituitary-adrenocortical axis in male Wistar rats
    • Korte, S. M., Van Duin, S., Bouws, G. A., Koolhaas, J. M., and Bohus, B. (1991). Involvement of hypothalamic serotonin in activation of the sympathoadrenomedullary system and hypothalamo-pituitary-adrenocortical axis in male Wistar rats. Eur. J. Pharmacol. 197, 225-228. doi: 10.1016/0014-2999(91)90527-W
    • (1991) Eur. J. Pharmacol. , vol.197 , pp. 225-228
    • Korte, S.M.1    Van Duin, S.2    Bouws, G.A.3    Koolhaas, J.M.4    Bohus, B.5
  • 43
    • 84865850718 scopus 로고    scopus 로고
    • Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus
    • Lee, S., Bookout, A. L., Lee, C. E., Gautron, L., Harper, M. J., Elias, C. F., et al. (2012b). Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus. J. Comp. Neurol. 520, 3617-3632. doi: 10.1002/cne.23116
    • (2012) J. Comp. Neurol , vol.520 , pp. 3617-3632
    • Lee, S.1    Bookout, A.L.2    Lee, C.E.3    Gautron, L.4    Harper, M.J.5    Elias, C.F.6
  • 44
    • 84866299596 scopus 로고    scopus 로고
    • Metabolic manifestations of insulin deficiency do not occur without glucagon action
    • Lee, Y., Berglund, E. D., Wang, M. Y., Fu, X., Yu, X., Charron, M. J., et al. (2012a). Metabolic manifestations of insulin deficiency do not occur without glucagon action. Proc. Natl. Acad. Sci. U.S.A. 109, 14972-14976. doi: 10.1073/pnas.1205983109
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109
    • Lee, Y.1    Berglund, E.D.2    Wang, M.Y.3    Fu, X.4    Yu, X.5    Charron, M.J.6
  • 45
    • 67849092898 scopus 로고    scopus 로고
    • Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
    • Leinninger, G. M., Jo, Y. H., Leshan, R. L., Louis, G. W., Yang, H., Barrera, J. G., et al. (2009). Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab. 10, 89-98. doi: 10.1016/j.cmet.2009.06.011
    • (2009) Cell Metab. , vol.10 , pp. 89-98
    • Leinninger, G.M.1    Jo, Y.H.2    Leshan, R.L.3    Louis, G.W.4    Yang, H.5    Barrera, J.G.6
  • 46
    • 80052707655 scopus 로고    scopus 로고
    • Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance
    • Leinninger, G. M., Opland, D. M., Jo, Y. H., Faouzi, M., Christensen, L., Cappellucci, L. A., et al. (2011). Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab. 14, 313-323. doi: 10.1016/j.cmet.2011.06.016
    • (2011) Cell Metab. , vol.14 , pp. 313-323
    • Leinninger, G.M.1    Opland, D.M.2    Jo, Y.H.3    Faouzi, M.4    Christensen, L.5    Cappellucci, L.A.6
  • 47
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • Lenzen, S. (2008). The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51, 216-226. doi: 10.1007/s00125-007-0886-7
    • (2008) Diabetologia , vol.51 , pp. 216-226
    • Lenzen, S.1
  • 48
    • 84860652458 scopus 로고    scopus 로고
    • Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance
    • Leshan, R. L., Greenwald-Yarnell, M., Patterson, C. M., Gonzalez, I. E., and Myers, M. G. Jr. (2012). Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat. Med. 18, 820-823. doi: 10.1038/nm.2724
    • (2012) Nat. Med. , vol.18 , pp. 820-823
    • Leshan, R.L.1    Greenwald-Yarnell, M.2    Patterson, C.M.3    Gonzalez, I.E.4    Myers, M.G.5
  • 49
    • 0041319087 scopus 로고    scopus 로고
    • Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses
    • Lu, X. Y., Barsh, G. S., Akil, H., and Watson, S. J. (2003). Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J. Neurosci. 23, 7863-7872.
    • (2003) J. Neurosci. , vol.23 , pp. 7863-7872
    • Lu, X.Y.1    Barsh, G.S.2    Akil, H.3    Watson, S.J.4
  • 50
    • 0017165051 scopus 로고
    • Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells
    • Mains, R. E., and Eipper, B. A. (1976). Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells. J. Biol. Chem. 251, 4115-4120.
    • (1976) J. Biol. Chem. , vol.251 , pp. 4115-4120
    • Mains, R.E.1    Eipper, B.A.2
  • 53
    • 84883172997 scopus 로고    scopus 로고
    • Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia
    • Meek, T. H., Matsen, M. E., Dorfman, M. D., Guyenet, S. J., Damian, V., Nguyen, H. T., et al. (2013). Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. Endocrinology 154, 3067-3076. doi: 10.1210/en.2013-1328
    • (2013) Endocrinology , vol.154 , pp. 3067-3076
    • Meek, T.H.1    Matsen, M.E.2    Dorfman, M.D.3    Guyenet, S.J.4    Damian, V.5    Nguyen, H.T.6
  • 54
    • 0032971214 scopus 로고    scopus 로고
    • Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
    • Minokoshi, Y., Haque, M. S., and Shimazu, T. (1999). Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes 48, 287-291. doi: 10.2337/diabetes.48.2.287
    • (1999) Diabetes , vol.48 , pp. 287-291
    • Minokoshi, Y.1    Haque, M.S.2    Shimazu, T.3
  • 55
    • 0032915413 scopus 로고    scopus 로고
    • Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
    • Mizuno, T. M., and Mobbs, C. V. (1999). Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140, 814-817.
    • (1999) Endocrinology , vol.140 , pp. 814-817
    • Mizuno, T.M.1    Mobbs, C.V.2
  • 57
    • 84856975510 scopus 로고    scopus 로고
    • Challenges and opportunities of defining clinical leptin resistance
    • Myers, M. G. Jr. Heymsfield, S. B., Haft, C., Kahn, B. B., Laughlin, M., Leibel, R. L., et al. (2012). Challenges and opportunities of defining clinical leptin resistance. Cell Metab. 15, 150-156. doi: 10.1016/j.cmet.2012.01.002
    • (2012) Cell Metab. , vol.15 , pp. 150-156
    • Myers, M.G.1    Heymsfield, S.B.2    Haft, C.3    Kahn, B.B.4    Laughlin, M.5    Leibel, R.L.6
  • 58
    • 34548604499 scopus 로고    scopus 로고
    • Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    • Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C. Y., et al. (2007). Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449, 228-232. doi: 10.1038/nature06098
    • (2007) Nature , vol.449 , pp. 228-232
    • Parton, L.E.1    Ye, C.P.2    Coppari, R.3    Enriori, P.J.4    Choi, B.5    Zhang, C.Y.6
  • 59
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., et al. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543. doi: 10.1126/science.7624776
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3    Hecht, R.4    Winters, D.5    Boone, T.6
  • 60
    • 84904000735 scopus 로고    scopus 로고
    • Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis
    • Perry, R. J., Zhang, X. M., Zhang, D., Kumashiro, N., Camporez, J. P., Cline, G. W., et al. (2014). Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nat. Med. 20, 759-763. doi: 10.1038/nm.3579
    • (2014) Nat. Med. , vol.20 , pp. 759-763
    • Perry, R.J.1    Zhang, X.M.2    Zhang, D.3    Kumashiro, N.4    Camporez, J.P.5    Cline, G.W.6
  • 61
    • 84908133922 scopus 로고    scopus 로고
    • Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake
    • Rezai-Zadeh, K., Yu, S., Jiang, Y., Laque, A., Schwartzenburg, C., Morrison, C. D., et al. (2014). Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake. Mol. Metab. 3, 681-693. doi: 10.1016/j.molmet.2014.07.008
    • (2014) Mol. Metab. , vol.3 , pp. 681-693
    • Rezai-Zadeh, K.1    Yu, S.2    Jiang, Y.3    Laque, A.4    Schwartzenburg, C.5    Morrison, C.D.6
  • 63
    • 84868122218 scopus 로고    scopus 로고
    • Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature
    • Rother, E., Belgardt, B. F., Tsaousidou, E., Hampel, B., Waisman, A., Myers, M. G. Jr., et al. (2012). Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature. Proc. Natl. Acad. Sci. U.S.A. 109, 18132-18137. doi: 10.1073/pnas.1206147109
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109
    • Rother, E.1    Belgardt, B.F.2    Tsaousidou, E.3    Hampel, B.4    Waisman, A.5    Myers, M.G.6
  • 64
    • 0034899321 scopus 로고    scopus 로고
    • Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice
    • Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Noda, M., Inui, Y., et al. (2001). Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat. Biotechnol. 19, 746-750. doi: 10.1038/90795
    • (2001) Nat. Biotechnol. , vol.19 , pp. 746-750
    • Saito, M.1    Iwawaki, T.2    Taya, C.3    Yonekawa, H.4    Noda, M.5    Inui, Y.6
  • 65
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., et al. (1996). Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45, 531-535. doi: 10.2337/diab.45.4.531
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3    Kuijper, J.L.4    Foster, D.5    Lasser, G.6
  • 66
    • 0034611732 scopus 로고    scopus 로고
    • Central nervous system control of food intake
    • Schwartz, M. W., Woods, S. C., Porte, D. Jr. Seeley, R. J., and Baskin, D. G. (2000). Central nervous system control of food intake. Nature 404, 661-671. doi: 10.1038/35007534
    • (2000) Nature , vol.404 , pp. 661-671
    • Schwartz, M.W.1    Woods, S.C.2    Porte, D.3    Seeley, R.J.4    Baskin, D.G.5
  • 67
    • 84906979430 scopus 로고    scopus 로고
    • MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus
    • Shah, B. P., Vong, L., Olson, D. P., Koda, S., Krashes, M. J., Ye, C., et al. (2014). MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc. Natl. Acad. Sci. U.S.A. 111, 13193-13198. doi: 10.1073/pnas.1407843111
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111
    • Shah, B.P.1    Vong, L.2    Olson, D.P.3    Koda, S.4    Krashes, M.J.5    Ye, C.6
  • 68
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., and Goldstein, J. L. (1999). Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401, 73-76. doi: 10.1038/43448
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 69
    • 78049445907 scopus 로고    scopus 로고
    • Brain expression of Cre recombinase driven by pancreas-specific promoters
    • Song, J., Xu, Y., Hu, X., Choi, B., and Tong, Q. (2010). Brain expression of Cre recombinase driven by pancreas-specific promoters. Genesis 48, 628-634. doi: 10.1002/dvg.20672
    • (2010) Genesis , vol.48 , pp. 628-634
    • Song, J.1    Xu, Y.2    Hu, X.3    Choi, B.4    Tong, Q.5
  • 70
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., et al. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271. doi: 10.1016/0092-8674(95)90151-5
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3    Deng, N.4    Culpepper, J.5    Devos, R.6
  • 71
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel, F., Nepote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., et al. (2010). Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464, 1149-1154. doi: 10.1038/nature08894
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Nepote, V.2    Avril, I.3    Kohno, K.4    Desgraz, R.5    Chera, S.6
  • 72
    • 84855459920 scopus 로고    scopus 로고
    • Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
    • Unger, R. H., and Cherrington, A. D. (2012). Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J. Clin. Invest. 122, 4-12. doi: 10.1172/JCI60016
    • (2012) J. Clin. Invest. , vol.122 , pp. 4-12
    • Unger, R.H.1    Cherrington, A.D.2
  • 73
    • 41549111593 scopus 로고    scopus 로고
    • Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    • van de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., et al. (2008). Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149, 1773-1785. doi: 10.1210/en.2007-1132
    • (2008) Endocrinology , vol.149 , pp. 1773-1785
    • van de Wall, E.1    Leshan, R.2    Xu, A.W.3    Balthasar, N.4    Coppari, R.5    Liu, S.M.6
  • 75
    • 78650839802 scopus 로고    scopus 로고
    • A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis
    • Vianna, C. R., and Coppari, R. (2011). A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis. Endocrinology 152, 11-18. doi: 10.1210/en.2010-0778
    • (2011) Endocrinology , vol.152 , pp. 11-18
    • Vianna, C.R.1    Coppari, R.2
  • 77
    • 79960190012 scopus 로고    scopus 로고
    • Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    • Vong, L., Ye, C., Yang, Z., Choi, B., Chua, S. Jr., and Lowell, B. B. (2011). Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71, 142-154. doi: 10.1016/j.neuron.2011.05.028
    • (2011) Neuron , vol.71 , pp. 142-154
    • Vong, L.1    Ye, C.2    Yang, Z.3    Choi, B.4    Chua, S.5    Lowell, B.B.6
  • 79
    • 78049446505 scopus 로고    scopus 로고
    • Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain
    • Wicksteed, B., Brissova, M., Yan, W., Opland, D. M., Plank, J. L., Reinert, R. B., et al. (2010). Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59, 3090-3098. doi: 10.2337/db10-0624
    • (2010) Diabetes , vol.59 , pp. 3090-3098
    • Wicksteed, B.1    Brissova, M.2    Yan, W.3    Opland, D.M.4    Plank, J.L.5    Reinert, R.B.6
  • 80
    • 77249146406 scopus 로고    scopus 로고
    • Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    • Williams, K. W., Margatho, L. O., Lee, C. E., Choi, M., Lee, S., Scott, M. M., et al. (2010). Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J. Neurosci. 30, 2472-2479. doi: 10.1523/JNEUROSCI.3118-09.2010
    • (2010) J. Neurosci. , vol.30 , pp. 2472-2479
    • Williams, K.W.1    Margatho, L.O.2    Lee, C.E.3    Choi, M.4    Lee, S.5    Scott, M.M.6
  • 81
    • 79951990905 scopus 로고    scopus 로고
    • Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network
    • Williams, K. W., Scott, M. M., and Elmquist, J. K. (2011). Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network. Eur. J. Pharmacol. 660, 2-12. doi: 10.1016/j.ejphar.2010.11.042
    • (2011) Eur. J. Pharmacol. , vol.660 , pp. 2-12
    • Williams, K.W.1    Scott, M.M.2    Elmquist, J.K.3
  • 82
    • 0033316562 scopus 로고    scopus 로고
    • Physiological and anatomical circuitry between Agouti-related protein and leptin signaling
    • Wilson, B. D., Bagnol, D., Kaelin, C. B., Ollmann, M. M., Gantz, I., Watson, S. J., et al. (1999). Physiological and anatomical circuitry between Agouti-related protein and leptin signaling. Endocrinology 140, 2387-2397.
    • (1999) Endocrinology , vol.140 , pp. 2387-2397
    • Wilson, B.D.1    Bagnol, D.2    Kaelin, C.B.3    Ollmann, M.M.4    Gantz, I.5    Watson, S.J.6
  • 83
    • 0032948427 scopus 로고    scopus 로고
    • Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport
    • Yaspelkis, B. B. III. Ansari, L., Ramey, E. L., Holland, G. J., and Loy, S. F. (1999). Chronic leptin administration increases insulin-stimulated skeletal muscle glucose uptake and transport. Metab. Clin. Exp. 48, 671-676. doi: 10.1016/S0026-0495(99)90070-7
    • (1999) Metab. Clin. Exp. , vol.48 , pp. 671-676
    • Yaspelkis, B.B.1    Ansari, L.2    Ramey, E.L.3    Holland, G.J.4    Loy, S.F.5
  • 84
    • 52949140814 scopus 로고    scopus 로고
    • Making insulin-deficient type 1 diabetic rodents thrive without insulin
    • Yu, X., Park, B. H., Wang, M. Y., Wang, Z. V., and Unger, R. H. (2008). Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc. Natl. Acad. Sci. U.S.A. 105, 14070-14075. doi: 10.1073/pnas.0806993105
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105
    • Yu, X.1    Park, B.H.2    Wang, M.Y.3    Wang, Z.V.4    Unger, R.H.5
  • 85
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432. doi: 10.1038/372425a0
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.