Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer

Free Radical Biology and Medicine

Volumn 83, Issue , 2015, Pages 227-237

  Cieslak, John A ^a   Strother, Robert K ^a   Rawal, Malvika ^a   Du, Juan ^a   Doskey, Claire M ^b   Schroeder, Samuel R ^a   Button, Anna ^c   Wagner, Brett A ^a   Buettner, Garry R ^a,c   Cullen, Joseph J ^a,c,d  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CATALASE; CYTOTOXIC AGENT; GEMCITABINE; HYDROGEN PEROXIDE; MN(III)MESO TETRAKIS(N ETHYLPYRIDINIUM 2 YL) PORPHYRIN PENTACHLORIDE; MN(III)TETRAKIS(N METHYLPYRIDINIUM 4 YL) PORPHYRIN PENTACHLORIDE; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; H2AFX PROTEIN, HUMAN; HISTONE; METALLOPORPHYRIN; SCAVENGER; TETRAKIS(N-METHYL-4-PYRIDINIUMYL)PORPHINE MANGANESE(III) COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CLONOGENESIS; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PANCREAS CANCER; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; CATALYSIS; DRUG EFFECTS; DRUG POTENTIATION; DRUG SCREENING; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NUDE MOUSE; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; PANCREATIC NEOPLASMS; PATHOLOGY;

MUS;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; ASCORBIC ACID; CATALASE; CATALYSIS; DEOXYCYTIDINE; DRUG SYNERGISM; FLUORESCENT ANTIBODY TECHNIQUE; FREE RADICAL SCAVENGERS; HISTONES; HUMANS; HYDROGEN PEROXIDE; METALLOPORPHYRINS; MICE; MICE, NUDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PANCREATIC NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84928157169     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.02.018     Document Type: Article

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