Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours

British Journal of Cancer

Volumn 84, Issue 11, 2001, Pages 1544-1550

  Casciari, J J ^a   Riordan, N H ^a   Schmidt, T L ^a   Meng, X L ^a   Jackson, J A ^b   Riordan, H D ^a  

^a Bio Communications Research Institute   (United States)

^b WICHITA STATE UNIVERSITY   (United States)

Author keywords

Ascorbic acid (vitamin C); Dose response relationship, drug; Thioctic acid (lipoic acid); Tumour cells, cultured; Vitamin K

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; THIOCTIC ACID;

APOPTOSIS; ARTICLE; BLOOD SAMPLING; CANCER SURVIVAL; CELL KILLING; CELL PROLIFERATION; CYTOTOXICITY; EXTRACELLULAR MATRIX; GROWTH INHIBITION; HOLLOW FIBER MEMBRANE; HUMAN; HUMAN CELL; INTERNALIZATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; TUMOR GROWTH;

ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CARCINOMA; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG INTERACTIONS; HUMANS; NECROSIS; THIOCTIC ACID; TUMOR CELLS, CULTURED;

EID: 0035364974     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1814     Document Type: Article

References (33)

1. Stromal cell oxidation: A mechanism by which tumors obtain vitamin C
2. Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3-amino-1,2,4,-triazole
3. Vitamin C preferential toxicity for malignant melanoma cells
4. The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer
5. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer
6. Ascorbic acid and cancer: A review
7. Growth and chemotherapeutic response of cells in a hollow fiber in vitro solid tumor model
8. Pharmacokinetics and clinical monitoring
9. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial
10. Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs
11. Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro
12. Determination of Ascorbic Acid
13. Ascorbic acid: Biologic functions and relation to cancer
14. Distribution of ascorbic acid, metabolites and analogues in man and animals
15. High dose intravenous vitamin C and long time survival of a patient with cancer of the head of the pancreas
16. Hydrogen peroxide cytotoxicity: Low-temperature enhancement by ascorbate or reduced lipoate
17. Toxicity, radiation sensitivity modification, and metabolic effects of dehydroascorbate and ascorbate in mammalian cells
18. Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro
19. Quantititve determination of water and lipid soluble antioxidants in neoplastic and non-neoplastic human breast tissue
20. Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines
21. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison
22. Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate
23. Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action
24. Toxicity, radiation sensitivity modification, and combined drug effects of ascorbic acid with misonidazole in vivo on FSaII murine fibrosarcomas
25. Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant?
26. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: A randomized controlled trial
27. Antioxidants may help cancers thrive
28. High-dose intravenous vitamin C in the treatment of a patient with renal cell carcinoma of the kidney
29. Case study: High-dose intravenous vitamin C in the treatment of a patient with adenocarcinoma of the kidney
30. Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent
31. Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice hearing solid transplantable tumor
32. In vivo antineoplastic activity of ascorbic acid for human mammary tumor
33. Inhibition of transplantable melanoma tumor development in mice by prophylactic administration of Ca-ascorbate