Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure

Journal of the American Heart Association

Volumn 3, Issue 3, 2014, Pages

  Wu, Chia Yen C ^a   Chen, Biyi ^d   Jiang, Ya Ping ^a   Jia, Zhiheng ^c   Martin, Dwight W ^b   Liu, Shengnan ^a   Entcheva, Emilia ^a,c   Song, Long Sheng ^d   Lin, Richard Z ^a,e  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c St Francis Hospital The Heart Center   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Calpain; G protein; Heart failure; Junctophilin 2; T tubules

Indexed keywords

CALPAIN; CALPASTATIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; JUNCTOPHILIN 2; MEMBRANE PROTEIN; PHOSPHOLIPASE C BETA; RYANODINE RECEPTOR 2; TAMOXIFEN; UNCLASSIFIED DRUG; CALCIUM; JUNCTOPHILIN-2 PROTEIN, MOUSE; MUSCLE PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; HEART FAILURE; MEMBRANE DAMAGE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSIBLE HEART FAILURE; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; TRANSVERSE TUBULAR SYSTEM; ANIMAL; C57BL MOUSE; DISEASE NOTIFICATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CALCIUM; CALPAIN; DISEASE NOTIFICATION; DOWN-REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEART FAILURE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE CELLS; MUSCLE PROTEINS; PROTEOLYSIS; SIGNAL TRANSDUCTION;

EID: 84928105906     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000527     Document Type: Article

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