Sildenafil prevents and reverses transverse-tubule remodeling and Ca 2+ handling dysfunction in right ventricle failure induced by pulmonary artery hypertension

Hypertension

Volumn 59, Issue 2, 2012, Pages 355-362

  Xie, Yu Ping ^a,b   Chen, Biyi ^a   Sanders, Philip ^a   Guo, Ang ^a   Li, Yue ^a   Zimmerman, Kathy ^c   Wang, Lie Cheng ^b   Weiss, Robert M ^a   Grumbach, Isabella M ^a,c   Anderson, Mark E ^a   Song, Long Sheng ^a  

^a UNIVERSITY OF IOWA   (United States)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c Affairs Medical Center   (United States)

Author keywords

Calcium; Excitation contraction coupling; PDE5 inhibitor; Pulmonary artery hypertension; Right ventricle failure; T tubule

Indexed keywords

CALCIUM; MONOCROTALINE; SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; DISORIENTATION; EARLY INTERVENTION; EXCITATION CONTRACTION COUPLING; HEART LEFT VENTRICLE FILLING; HEART MUSCLE CELL; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SARCOPLASMIC RETICULUM; ULTRASTRUCTURE;

ANIMALS; CALCIUM; DISEASE MODELS, ANIMAL; EXCITATION CONTRACTION COUPLING; HEART FAILURE; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; MICROSCOPY, CONFOCAL; MONOCROTALINE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, WISTAR; SULFONES; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR REMODELING;

EID: 84856240643     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.180968     Document Type: Article

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