Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors

Biomaterials

Volumn 53, Issue , 2015, Pages 160-172

  Wang, Ai Ting ^a   Liang, De Sheng ^a   Liu, Yu Jie ^a   Qi, Xian Rong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Hybrid micelles; Mitochondrial membrane potential; Multidrug resistance; P gp function; Permeation and accumulation in solid tumor; Synergistic effect

Indexed keywords

CELL DEATH; CELL PROLIFERATION; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; LIGANDS; MAGNESIUM PRINTING PLATES; MAMMALS; MICELLES; MITOCHONDRIA; MOLECULAR BIOLOGY; PERMEATION; PETROLEUM RESERVOIR EVALUATION; SUBSTRATES; TUMORS;

HYBRID MICELLE; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIDRUG RESISTANCE; SOLID TUMORS; SYNERGISTIC EFFECT;

TARGETED DRUG DELIVERY;

DISTEAROYLPHOSPHATIDYL ETHANOLAMINE; DOCETAXEL; DRUG CARRIER; ETHANOLAMINE; FOLATE RECEPTOR; FOLIC ACID; LIGAND; MACROGOL 2000; MULTIDRUG RESISTANCE PROTEIN; TOCOFERSOLAN; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; ALPHA-TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; ANTINEOPLASTIC AGENT; MACROGOL DERIVATIVE; MICELLE; TAXOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER GROWTH; CANCER INHIBITION; CANCER RESISTANCE; CANCER THERAPY; CELL CYCLE; CELL CYCLE ASSAY; CELL MEMBRANE TRANSPORT; CELLULAR DISTRIBUTION; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; DRUG SAFETY; DRUG TARGETING; ENDOCYTOSIS; FEMALE; HYDROPHOBICITY; IN VIVO STUDY; INTERNALIZATION; MICELLE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TUMOR CELL; TUMOR SPHEROID; TUMOR VOLUME; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; MULTIDRUG RESISTANCE;

MUS MUSCULUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; LIGANDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICELLES; P-GLYCOPROTEIN; POLYETHYLENE GLYCOLS; TAXOIDS; VITAMIN E;

EID: 84927914649     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.02.077     Document Type: Article

References (54)

1. Gao Z., Zhang L., Sun Y. Nanotechnology applied to overcome tumor drug resistance. JControl Release 2012, 162:45-55.
2. Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
3. Marcucci F., Corti A. How to improve exposure of tumor cells to drugs - promoter drugs increase tumor uptake and penetration of effector drugs. Adv Drug Deliv Rev 2011, 64:53-68.
4. Gillet J.P., Gottesman M.M. Overcoming multidrug resistance in cancer: 35 years after the discovery of ABCB1. Drug Resist Updates 2012, 15:2-4.
5. Ganguly A., Banerjee K., Chakraborty P., Das S., Sarkar A., Hazra A., et al. Overcoming multidrug resistance (MDR) in cancer invitro and invivo by a quinoline derivative. Biomed Pharmacother 2011, 65:387-394.
6. Krishna R., Mayer L.D. Multidrug resistance (MDR) in cancer: mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 2000, 11:265-283.
7. Li-Blatter X., Nervi P., Seelig A. Detergents as intrinsic P-glycoprotein substrates and inhibitors. Biochim Biophys Acta 2009, 1788:2335-2344.
8. Nervi P., Li-Blatter X., Aanismaa P., Seelig A. P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity. Biochim Biophys Acta 2010, 1798:515-525.
9. Sikic B.I., Fisher G.A., Lum B.L., Halsey J., Beketic-Oreskovic L., Chen G. Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer Chemother Pharmacol 1997, 40:S13-S19.
10. Lukyanov A.N., Torchilin V.P. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv Drug Deliv Rev 2004, 56:1273-1289.
11. Gao Z., Lukyanov A.N., Singhal A., Torchilin V.P. Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Lett 2002, 2:979-982.
12. Tong S.W., Xiang B., Dong D.W., Qi X.R. Enhanced antitumor efficacy and decreased toxicity by self-associated docetaxel in phospholipid-based micelles. Int J Pharm 2012, 434:413-419.
13. Fang J., Nakamura H., Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev 2011, 63:136-151.
14. Gaucher G., Dufresne M., Sant V.P., Kang N., Maysinger D., Leroux J. Block copolymer micelles: preparation, characterization and application in drug delivery. JControl Release 2005, 109:169-188.
15. Weitman S.D., Lark R.H., Coney L.R., Fort D.W., Frasca V., Zurawski V.R., et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 1992, 52:3396-3401.
16. Allen T.M. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002, 2:750-763.
17. Zhao X., Zhao Y., Geng L., Li X., Wang X., Liu Z., et al. Pharmacokinetics and tissue distribution of docetaxel by liquid chromatography-mass spectrometry: evaluation of folate receptor-targeting amphiphilic copolymer modified nanostructured lipid carrier. JChromatogr B Anal Technol Biomed Life Sci 2011, 879:3721-3727.
18. Sabharanjak S., Mayor S. Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev 2004, 56:1099-1109.
19. Leamon C.P., Reddy J.A. Folate-targeted chemotherapy. Adv Drug Deliv Rev 2004, 56:1127-1141.
20. Gao W., Xiang B., Meng T.T., Liu F., Qi X.R. Chemotherapeutic drug delivery to cancer cells using a combination of folate targeting and tumor microenvironment-sensitive polypeptides. Biomaterials 2013, 34:4137-4149.
21. Dong D.W., Xiang B., Gao W., Yang Z., Li J., Qi X. pH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells. Biomaterials 2013, 34:4849-4859.
22. Guo Y., Luo J., Tan S., Otieno B.O., Zhang Z. The applications of vitamin E TPGS in drug delivery. Eur J Pharm Sci 2013, 49:175-186.
23. Liang B., He M.L., Chan C.Y., Chen Y.C., Li X.P., Li Y., et al. The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat. Biomaterials 2009, 30:4014-4020.
24. Liu B., Yang M., Li R., Ding Y., Qian X., Yu L., et al. The antitumor effect of novel docetaxel-loaded thermosensitive micelles. Eur J Pharm Biopharm 2008, 69:527-534.
25. Meaden E.R., Hoggard P.G., Khoo S.H., Back D.J. Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells invivo. JImmunol Methods 2002, 262:159-165.
26. Fiskus W., Rao R., Fernandez P., Herger B., Yang Y., Chen J., et al. Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. Blood 2008, 112:2896-2905.
27. Hsiao A.Y., Tung Y., Qu X., Patel L.R., Pienta K.J., Takayama S. 384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids. Biotechnol Bioeng 2012, 109:1293-1304.
28. Kostarelos K., Emfietzoglou D., Papakostas A., Yang W.H., Ballangrud A., Sgouros G. Binding and interstitial penetration of liposomes within avascular tumor spheroids. Int J Cancer 2004, 112:713-721.
29. Xiang B., Dong D., Shi N., Gao W., Yang Z., Cui Y., et al. PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer. Biomaterials 2013, 34:6976-6991.
30. Koide H., Asai T., Hatanaka K., Urakami T., Ishii T., Kenjo E., et al. Particle size-dependent triggering of accelerated blood clearance phenomenon. Int J Pharm 2008, 362:197-200.
31. Koide H., Asai T., Kato H., Ando H., Shiraishi K., Yokoyama M., et al. Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles. Int J Pharm 2012, 432:75-79.
32. Lu J.Q., Huang Y.X., Zhao W.C., Chen Y.C., Li J., Gao X., et al. Design and characterization of PEG-derivatized vitamin e as a nanomicellar formulation for delivery of paclitaxel. Mol Pharm 2013, 10:2880-2890.
33. Bao Y.L., Guo Y.Y., Zhuang X.T., Li D., Cheng B.L., Tan S.W., et al. D-α-tocopherol polyethylene glycol succinate-based redox-sensitive paclitaxel prodrug for overcoming multidrug resistance in Cancer cells. Mol Pharm 2014, 11:3196-3209.
34. Constantinides P.P., Han J.H., Davis S.S. Advances in the use of tocols as drug delivery vehicles. Pharm Res 2006, 23:243-255.
35. Gill K.K., Kaddoumi A., Nazzal S. Mixed micelles of PEG2000-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines. Eur J Pharm Sci 2012, 46:64-71.
36. Sawant R.R., Sawant R.M., Torchilin V.P. Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced invitro cytotoxicity. Eur J Pharm Biopharm 2008, 70:51-57.
37. Mu L., Elbayoumi T.A., Torchilin V.P. Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and d-α-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin. Int J Pharm 2005, 306:142-149.
38. Wang Y.Z., Fan W., Dai X., Katragadda U., Mckinley D., Teng Q., et al. Enhanced tumor delivery of gemcitabine via PEG-DSPE/TPGS mixed micelles. Mol Pharm 2014, 11:1140-1150.
39. Gibot L., Lemelle A., Till U., Moukarzel B., Mingotaud A., Pimienta V., et al. Polymeric micelles encapsulating photosensitizer: structure/photodynamic therapy efficiency relation. Biomacromolecules 2014, 15:1443-1455.
40. Goren D., Horowitz A.T., Tzemach D., Tarshish M., Zalipsky S., Gabizon A. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin Cancer Res 2000, 6:1949-1957.
41. Saul J.M., Annapragada A., Natarajan J.V., Bellamkonda R.V. Controlled targeting of liposomal doxorubicin via the folate receptor invitro. JControl Release 2003, 92:49-67.
42. Mi Y., Liu Y., Feng S. Formulation of docetaxel by folic acid-conjugated d-α-tocopheryl polyethylene glycol succinate 2000 (vitamin E TPGS2k) micelles for targeted and synergistic chemotherapy. Biomaterials 2011, 32:4058-4066.
43. Neuzil J., Dyason J.C., Freeman R., Dong L., Prochazka L., Wang X., et al. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. JBioenerg Biomembr 2007, 39:65-72.
44. Quin J., Engle D., Litwiller A., Peralta E., Grasch A., Boley T., et al. Vitamin E succinate decreases lung cancer tumor growth in mice. JSurg Res 2005, 127:139-143.
45. Han X., Liu J., Liu M., Xie C., Zhan C., Gu B., et al. 9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation invitro. Int J Pharm 2009, 372:125-131.
46. Escobar P.F., Rose P.G. Docetaxel in ovarian cancer. Expert Opin Pharmacother 2005, 6:2719-2726.
47. Debatin K., Poncet D., Kroemer G. Chemotherapy: targeting the mitochondrial cell death pathway. Oncogene 2002, 21:8786-8803.
48. Wang X., Li Y., Yao H., Ju R., Zhang Y., Li R., et al. The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells. Biomaterials 2011, 32:5673-5687.
49. Xi G., Sun B., Jiang H., Kong F., Yuan H., Lou H. Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. Bioorg Med Chem 2010, 18:6725-6733.
50. Li P.Y., Lai P.S., Hung W.C., Syu W.J. Poly(L-lactide)-vitamin E TPGS nanoparticles enhanced the cytotoxicity of doxorubicin in drug-resistant MCF-7 breast cancer cells. Biomacromolecules 2010, 11:2576-2582.
51. Sarisozen C., Abouzeid A.H., Torchilin V.P. The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and invivo tumors. Eur J Pharm Biopharm 2014, 88:539-550.
52. Michishita M., Akiyoshi R., Yoshimura H., Katsumoto T., Ichikawa H., Ohkusu-Tsukada K., et al. Characterization of spheres derived from canine mammary gland adenocarcinoma cell lines. Res Vet Sci 2011, 91:254-260.
53. Correia A.L., Bissell M.J. The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updates 2012, 15:39-49.
54. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 2011, 6:815-823.