Vitamin E succinate decreases lung cancer tumor growth in mice

Journal of Surgical Research

Volumn 127, Issue 2, 2005, Pages 139-143

  Quin, Jacquelyn ^a   Engle, Deborah ^a   Litwiller, Abigail ^a   Peralta, Elizabeth ^a   Grasch, Anthony ^a   Boley, Theresa ^a   Hazelrigg, Stephen ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lung cancer; Mouse; Vitamin E succinate (alpha tocopherol succinate)

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; DIMETHYL SULFOXIDE; EOSIN; HEMATOXYLIN; MACROGOL;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INJECTION SITE; LUNG CANCER; LUNG METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; STAINING; STATISTICAL SIGNIFICANCE; STUDENT T TEST; TUMOR GROWTH; TUMOR VOLUME; VITAMIN SUPPLEMENTATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; VITAMIN E;

EID: 23144462797     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2005.01.014     Document Type: Article

References (19)

1. J. Neuzil, T. Weber, N. Gellert, C. Weber Selective cancer cell killing by alpha-tocopheryl succinate Br. J. Cancer 84 2001 87
2. M.P. Malafa, L.T. Neitzel Vitamin E succinate promotes breast cancer tumor dormancy J. Surg. Res. 93 2000 163
3. M.P. Malafa, F.D. Fokum, L. Smith, A. Louis Inhibition of angiogenesis and promotion of melanoma dormancy by vitamin E succinate Ann. Surg. Oncol. 9 2002 1023
4. K.T. Barnett, F.D. Fokum, M.P. Malafa Vitamin E succinate inhibits colon cancer liver metastases J. Surg. Res. 106 2002 292
5. American Cancer Society. Cancer Facts and Figures 2004. Available at: http://www.cancer.org/downloads/STT/CAFF_finalPWSecured.pdf. Accessed February 15, 2005.
6. Vaporciyan, A. A., Nesbitt, J. C., Lee, J. S., et al. Cancer of the lung. In R. C. Bast (Ed.), Cancer Medicine (5th ed). Hamilton, B.C. Decker Inc, 2000 [Electronic Version]. Available at: http://www.ncbi.nlm.nih.gov/books/bv.fcgi? rid=cmed.chapter.20745. Accessed February 15, 2005.
7. N. Martini, M.S. Bains, M.E. Burt, M.F. Zakowski, P. McCormack, V.W. Rusch, R.J. Ginsberg Incidence of local recurrence and second primary tumors in resected stage I lung cancer J. Thorac. Cardiovasc. Surg. 109 1995 120
8. J. Neuzil Vitamin E succinate and cancer treatment: A vitamin E prototype for selective antitumor activity Br. J. Cancer 89 2003 1822
9. T. Weber, M. Lu, L. Andera, H. Lahm, N. Gellert, M.W. Fariss, V. Korinek, W. Sattler, D.S. Ucker, A. Terman, A. Schroder, W. Erl, U.T. Brunk, R.J. Coffey, C. Weber, J. Neuzil Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperatively with tumor necrosis factor-related apoptosis-inducing ligand (apo2ligand) in vivo Clin. Cancer Res. 8 2002 863
10. R.H. Hastings, D.W. Burton, D. Summers-Torres, R. Quintana, E. Biederman, L.J. Deftos Splenic, thymic, bony and lymph node metastases from orthotopic human lung carcinomas in immunocompromised mice Anticancer Res. 20 2000 3625
11. T. Yamaura, K. Murakami, Y. Doki, S. Sugiyama, T. Misaki, Y. Yamada, I. Saiki Solitary lung tumors and their spontaneous metastasis in athymic nude mice orthotopically implanted with human non-small cell lung cancer Neoplasia 2 2000 315
12. J. Schwartz, V. Vaker, E. Larios, D. Desai, S. Amin Inhibition of experimental tobacco carcinogen induced head and neck carcinogenesis Oral Oncol. 40 2004 611
13. W. Yu, M. Simmons-Menchaca, A. Gapor, B.G. Sanders, K. Kline Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols Nutr. Cancer 33 1999 26
14. Z. Djuric, L.K. Heilbrun, S. Lababadi, C.K. Everett-Bauer, M.W. Fariss Growth inhibition of MCF-7 and MCF-10A human breast cells by alpha-tocopherol hemisuccinate, cholesterol hemisuccinate and their ether analogs Cancer Lett. 111 1997 133
15. M. Birringer, J.H. EyTina, B.A. Salvatore, J. Neuzil Vitamin E analogues as inducers of apoptosis: structure-function relation Br. J. Cancer 88 2003 1948
16. J. Neuzil, T. Weber, A. Schroder, M. Lu, G. Ostermann, N. Gellert, G.C. Mayne, B. Olejnicka, A. Negre-Salvayre, M. Sticha, R.J. Coffey, C. Weber Induction of cancer cell apoptosis by alpha-tocopherol succinate: Molecular pathways and structural requirements FASEB J. 15 2001 403
17. H. Dalen, J. Neuzil Alpha-tocopheryl succinate sensitizes a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kappaB activation Br. J. Cancer 88 2003 153
18. T. Weber, H. Dalen, L. Andera, A. Negre-Salvayre, N. Auge, M. Sticha, A. Lloret, A. Terman, P.K. Witting, M. Higuchi, M. Plasilova, J. Zivny, N. Gellert, C. Weber, J. Neuzil Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling Biochemistry 42 2003 4277
19. K.A. Lawson, K. Anderson, M. Menchaca, J. Atkinson, L. Sun, V. Knight, B.E. Gilbert, C. Conti, B.G. Sanders, K. Kline Novel vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis Mol. Cancer Ther. 2 2003 437