Mixed micelles of PEG 2000-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: Enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines

European Journal of Pharmaceutical Sciences

Volumn 46, Issue 1-2, 2012, Pages 64-71

  Gill, Kanwaldeep K ^a   Kaddoumi, Amal ^a   Nazzal, Sami ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Mixed micelles; Non small cell lung cancer; Paclitaxel; Parthenolide; PEG lipid; Vitamin E TPGS

Indexed keywords

1,2 DISTEAROYL N GLYCERO 3 PHOSPHOETHANOLAMINE N AMINO(POLYETHYLENE GLYCOL) 2000; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA TOCOPHEROL; ALPHA TOCOPHERYL POLYETHYLENEGLYCOL SUCCINATE; MACROGOL 2000; PACLITAXEL; PARTHENOLIDE; POLYMER; TOCOFERSOLAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; ENCAPSULATION; FILM; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; KINETICS; LUNG NON SMALL CELL CANCER; MICELLE; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DRUG CARRIERS; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; PACLITAXEL; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; SESQUITERPENES; VITAMIN E;

EID: 84859218842     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.02.010     Document Type: Article

References (32)

1. Amiji, M., 2007. Nanotechnology for Cancer Therapy. CRC Press, Florida.
2. Bachawal, S.V., Wali, V.B., Sylvester, P.W., 2010. Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells. BMC Cancer 10, 84.
3. Champion, J.A., Walker, A., Mitragotri, S., 2008. Role of particle size in phagocytosis of polymeric microspheres. Pharm. Res. 25, 1815-1821.
4. Chandran, T., Katragadda, U., Teng, Q., Tan, C., 2010. Design and evaluation of micellar nanocarriers for 17-allyamino-17-demethoxygeldanamycin (17-AAG). Int. J. Pharm. 392, 170-177.
5. Collnot, E.M., Baldes, C., Wempe, M.F., Kappl, R., Huttermann, J., Hyatt, J.A., Edgar, K.J., Schaefer, U.F., Lehr, C.M., 2007. Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol. Pharm. 4, 465-474. (Pubitemid 46983960)
6. Dabholkar, R.D., Sawant, R.M., Mongayt, D.A., Devarajan, P.V., Torchilin, V.P., 2006. Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux. Int. J. Pharm. 315, 148-157. (Pubitemid 43674120)
7. Dintaman, J.M., Silverman, J.A., 1999. Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). Pharm. Res. 16, 1550-1556. (Pubitemid 29510551)
8. Gill, K.K., Nazzal, S., Kaddoumi, A., 2011. Paclitaxel loaded PEG(5000)-DSPE micelles as pulmonary delivery platform: Formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation. Eur. J. Pharm. Biopharm. 79, 276-284.
9. Greish, K., 2007. Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines. J. Drug Target. 15, 457-464. (Pubitemid 47209047)
10. Harper, E., Dang, W., Lapidus, R.G., Garver Jr., R.I., 1999. Enhanced efficacy of anovel controlled release paclitaxel formulation (PACLIMER delivery system) for local-regional therapy of lung cancer tumor nodules in mice. Clin. Cancer Res. 5, 4242-4248. (Pubitemid 30013811)
11. Jabr-Milane, L.S., Van Vlerken, L.E., Yadav, S., Amiji, M.M., 2008. Multi-functional nanocarriers to overcome tumor drug resistance. Cancer Treat. Rev. 34, 592-602.
12. Kishida, Y., Yoshikawa, H., Myoui, A., 2007. Parthenolide, anatural inhibitor of nuclear factor-kappaB, inhibits lung colonization of murine osteosarcoma cells. Clin. Cancer Res. 13, 59-67. (Pubitemid 46121853)
13. Lee, H., Hu, M., Reilly, R.M., Allen, C., 2007. Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy. Mol. Pharm. 4, 769-781. (Pubitemid 350004277)
14. Mabuchi, S., Ohmichi, M., Nishio, Y., Hayasaka, T., Kimura, A., Ohta, T., Kawagoe, J., Takahashi, K., Yada-Hashimoto, N., Seino-Noda, H., Sakata, M., Motoyama, T., Kurachi, H., Testa, J.R., Tasaka, K., Murata, Y., 2004. Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Clin. Cancer Res. 10, 7645-7654. (Pubitemid 39557528)
15. Maemondo, M., Inoue, A., Kobayashi, K., Sugawara, S., Oizumi, S., Isobe, H., Gemma, A., Harada, M., Yoshizawa, H., Kinoshita, I., Fujita, Y., Okinaga, S., Hirano, H., Yoshimori, K., Harada, T., Ogura, T., Ando, M., Miyazawa, H., Tanaka, T., Saijo, Y., Hagiwara, K., Morita, S., Nukiwa, T., 2010. Gefitinib orchemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362, 2380-2388.
16. Maione, P., Gridelli, C., Troiani, T., Ciardiello, F., 2006. Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC. Oncologist 11, 274-284.
17. Mu, L., Elbayoumi, T.A., Torchilin, V.P., 2005. Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and D-alpha-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin. Int. J. Pharm. 306, 142-149. (Pubitemid 41643148)
18. Niklinski, J., Niklinska, W., Laudanski, J., Chyczewska, E., Chyczewski, L., 2001. Prognostic molecular markers in non-small cell lung cancer. Lung Cancer 34 (Suppl. 2), S53-S58. (Pubitemid 33101846)
19. Nishiyama, N., Kataoka, K., 2006. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol. Ther. 112, 630-648. (Pubitemid 44592613)
20. Riedel, R.F., Porrello, A., Pontzer, E., Chenette, E.J., Hsu, D.S., Balakumaran, B., Potti, A., Nevins, J., Febbo, P.G., 2008. A genomic approach to identify molecular pathways associated with chemotherapy resistance. Mol. Cancer Ther. 7, 3141-3149.
21. Rosell, R., Felip, E., Garcia-Campelo, R., Balana, C., 2004. The biology of non-small-cell lung cancer: identifying new targets for rational therapy. Lung Cancer 46, 135-148. (Pubitemid 39330407)
22. Roy, A., Singh, M.S., Upadhyay, P., Bhaskar, S., 2010. Combined chemoimmunotherapy as aprospective strategy to combat cancer: a nanoparticle based approach. Mol. Pharm. 7 (5), 1778-1788.
23. Sawant, R.R., Sawant, R.M., Torchilin, V.P., 2008. Mixed PEG-PE/vitamin Etumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity. Eur. J. Pharm. Biopharm. 70, 51-57.
24. Sekido, Y., Fong, K.M., Minna, J.D., 1998. Progress in understanding the molecular pathogenesis of human lung cancer. Biochim. Biophys. Acta 1378, F21-F59. (Pubitemid 28381125)
25. Shin, H.C., Alani, A.W., Rao, D.A., Rockich, N.C., Kwon, G.S., 2009. Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs. J. Control Release 140, 294-300.
26. Torchilin, V., 2006. Nanoparticulates as Drug Carriers. Imperial College Press, London.
27. Wang, T., Petrenko, V.A., Torchilin, V.P., 2010a. Paclitaxel-loaded polymeric micelles modified with MCF-7 cell-specific phage protein: enhanced binding to target cancer cells and increased cytotoxicity. Mol. Pharm. 7, 1007-1014.
28. Wang, Y., Wang, R., Lu, X., Lu, W., Zhang, C., Liang, W., 2010b. Pegylated phospholipids-based self-assembly with water-soluble drugs. Pharm. Res. 27 (2), 361-370.
29. Xiao, L., Xiong, X., Sun, X., Zhu, Y., Yang, H., Chen, H., Gan, L., Xu, H., Yang, X., 2011. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials 32, 5148-5157.
30. Zhang, D., Qiu, L., Jin, X., Guo, Z., Guo, C., 2009. Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo. Mol. Cancer Res. 7, 1139-1149.
31. Zhang, W., Shi, Y., Chen, Y., Yu, S., Hao, J., Luo, J., Sha, X., Fang, X., 2010a. Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance. Eur. J. Pharm. Biopharm. 75, 341-353.
32. Zhang, Y.F., Wang, J.C., Bian, D.Y., Zhang, X., Zhang, Q., 2010b. Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy: in vitro and in vivo studies. Eur. J. Pharm. Biopharm. 74, 467-473.