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Volumn 27, Issue 6, 2014, Pages 528-534

Hepatitis B: Future curative strategies

Author keywords

Chronic hepatitis B; Toll like receptor agonist; Vaccine therapy

Indexed keywords

ANTIVIRUS AGENT; CIRCULAR DNA; HEPATITIS B VACCINE; TOLL LIKE RECEPTOR 8 AGONIST; UNCLASSIFIED DRUG; VIRUS PROTEIN; ALPHA INTERFERON; ALPHA2B INTERFERON; RECOMBINANT PROTEIN;

EID: 84927796555     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0000000000000110     Document Type: Review
Times cited : (27)

References (65)
  • 1
    • 84879327902 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
    • Yan H, Zhong G, Xu G, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. ELife 2012; 1:e00049-e00049.
    • (2012) ELife , vol.1 , pp. e00049-e00049
    • Yan, H.1    Zhong, G.2    Xu, G.3
  • 2
    • 84894237342 scopus 로고    scopus 로고
    • Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes
    • Ni Y, Lempp FA, Mehrle S, et al. Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology 2014; 146:1070-1083.
    • (2014) Gastroenterology , vol.146 , pp. 1070-1083
    • Ni, Y.1    Lempp, F.A.2    Mehrle, S.3
  • 4
    • 84868702241 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in chronic hepatitis B virus infections: Towards restoration of immune control of viral infection
    • Bertoletti A, Ferrari C. Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut 2012; 61:1754-1764.
    • (2012) Gut , vol.61 , pp. 1754-1764
    • Bertoletti, A.1    Ferrari, C.2
  • 5
    • 0037213545 scopus 로고    scopus 로고
    • CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • Thimme R, Wieland S, Steiger C, et al. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003; 77:68-76.
    • (2003) J Virol , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3
  • 6
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    • Boni C, Fisicaro P, Valdatta C, et al. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 2007; 81:4215-4225.
    • (2007) J Virol , vol.81 , pp. 4215-4225
    • Boni, C.1    Fisicaro, P.2    Valdatta, C.3
  • 7
    • 0030021968 scopus 로고    scopus 로고
    • Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
    • Guidotti LG, Ishikawa T, Hobbs MV, et al. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996; 4:25-36.
    • (1996) Immunity , vol.4 , pp. 25-36
    • Guidotti, L.G.1    Ishikawa, T.2    Hobbs, M.V.3
  • 8
    • 0034678435 scopus 로고    scopus 로고
    • The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection
    • Maini MK, Boni C, Lee CK, et al. The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med 2000; 191:1269-1280.
    • (2000) J Exp Med , vol.191 , pp. 1269-1280
    • Maini, M.K.1    Boni, C.2    Lee, C.K.3
  • 9
    • 2442682870 scopus 로고    scopus 로고
    • Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • Webster GJM, Reignat S, Brown D, et al. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 2004; 78:5707-5719.
    • (2004) J Virol , vol.78 , pp. 5707-5719
    • Webster, G.J.M.1    Reignat, S.2    Brown, D.3
  • 10
    • 0027453541 scopus 로고
    • Mechanisms of class i restricted immunopathology. A transgenic mouse model of fulminant hepatitis
    • Ando K, Moriyama T, Guidotti LG, et al. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J Exp Med 1993; 178:1541-1554.
    • (1993) J Exp Med , vol.178 , pp. 1541-1554
    • Ando, K.1    Moriyama, T.2    Guidotti, L.G.3
  • 11
    • 0035905411 scopus 로고    scopus 로고
    • Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    • Kakimi K, Lane TE, Wieland S, et al. Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J Exp Med 2001; 194:1755-1766.
    • (2001) J Exp Med , vol.194 , pp. 1755-1766
    • Kakimi, K.1    Lane, T.E.2    Wieland, S.3
  • 12
    • 2142763034 scopus 로고    scopus 로고
    • MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs
    • Sitia G, Isogawa M, Iannacone M, et al. MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. J Clin Invest 2004; 113:1158-1167.
    • (2004) J Clin Invest , vol.113 , pp. 1158-1167
    • Sitia, G.1    Isogawa, M.2    Iannacone, M.3
  • 14
    • 84896029673 scopus 로고    scopus 로고
    • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • Lucifora J, Xia Y, Reisinger F, et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 2014; 343:1221-1228.
    • (2014) Science , vol.343 , pp. 1221-1228
    • Lucifora, J.1    Xia, Y.2    Reisinger, F.3
  • 15
    • 70349568358 scopus 로고    scopus 로고
    • A lymphotoxin-driven pathway to hepatocellular carcinoma
    • Haybaeck J, Zeller N, Wolf MJ, et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 2009; 16:295-308.
    • (2009) Cancer Cell , vol.16 , pp. 295-308
    • Haybaeck, J.1    Zeller, N.2    Wolf, M.J.3
  • 16
    • 84895908706 scopus 로고    scopus 로고
    • An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases
    • Chen J, Zhang W, Lin J, et al. An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases. Mol Ther 2013; 22:303-311.
    • (2013) Mol Ther , vol.22 , pp. 303-311
    • Chen, J.1    Zhang, W.2    Lin, J.3
  • 17
    • 0025147370 scopus 로고
    • Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
    • Milich DR, Jones JE, Hughes JL, et al. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci U S A 1990; 87:6599-6603.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 6599-6603
    • Milich, D.R.1    Jones, J.E.2    Hughes, J.L.3
  • 18
    • 84877026189 scopus 로고    scopus 로고
    • Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection
    • Wooddell CI, Rozema DB, Hossbach M, et al. Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection. Mol Ther 2013; 21:973-985.
    • (2013) Mol Ther , vol.21 , pp. 973-985
    • Wooddell, C.I.1    Rozema, D.B.2    Hossbach, M.3
  • 19
    • 40449096921 scopus 로고    scopus 로고
    • Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
    • Petersen J, Dandri M, Mier W, et al. Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotechnol 2008; 26:335-341.
    • (2008) Nat Biotechnol , vol.26 , pp. 335-341
    • Petersen, J.1    Dandri, M.2    Mier, W.3
  • 20
  • 21
    • 77949655584 scopus 로고    scopus 로고
    • The molecular basis of the failed immune response in chronic HBV: Therapeutic implications
    • Maini MK, Schurich A. The molecular basis of the failed immune response in chronic HBV: therapeutic implications. J Hepatol 2010; 52:616-619.
    • (2010) J Hepatol , vol.52 , pp. 616-619
    • Maini, M.K.1    Schurich, A.2
  • 22
    • 84866705034 scopus 로고    scopus 로고
    • Restored function of HBV-specific T cells after long term effective treatment with nucleos(t)ide analogues
    • Boni C, Laccabue D, Lampertico P, et al. Restored function of HBV-specific T cells after long term effective treatment with nucleos(t)ide analogues. Gastroenterology 2012; 143:963.e9-973.e9.
    • (2012) Gastroenterology , vol.143 , pp. 963e9-973e9
    • Boni, C.1    Laccabue, D.2    Lampertico, P.3
  • 23
    • 79955112364 scopus 로고    scopus 로고
    • Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-prone CD8 T cells in persistent hepatitis B virus infection
    • Schurich A, Khanna P, Lopes AR, et al. Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-prone CD8 T cells in persistent hepatitis B virus infection. Hepatology 2011; 53:1494-1503.
    • (2011) Hepatology , vol.53 , pp. 1494-1503
    • Schurich, A.1    Khanna, P.2    Lopes, A.R.3
  • 24
    • 0035925668 scopus 로고    scopus 로고
    • Immunotherapy of chronic hepatitis B by anti HBV vaccine: From present to future
    • Michel ML, Pol S, Brechot C, Tiollais P. Immunotherapy of chronic hepatitis B by anti HBV vaccine: from present to future. Vaccine 2001; 19:2395-2399.
    • (2001) Vaccine , vol.19 , pp. 2395-2399
    • Michel, M.L.1    Pol, S.2    Brechot, C.3    Tiollais, P.4
  • 25
    • 70449698040 scopus 로고    scopus 로고
    • Therapeutic vaccination and novel strategies to treat chronic HBV infection
    • Bertoletti A, Gehring A. Therapeutic vaccination and novel strategies to treat chronic HBV infection. Expert Rev Gastroenterol Hepatol 2009; 3:561-569.
    • (2009) Expert Rev Gastroenterol Hepatol , vol.3 , pp. 561-569
    • Bertoletti, A.1    Gehring, A.2
  • 26
    • 0034948510 scopus 로고    scopus 로고
    • Multicenter study group: Efficacy and limitations of a specific immunotherapy in chronic hepatitis B
    • Pol S, Nalpas B, Driss F, et al. Multicenter study group: efficacy and limitations of a specific immunotherapy in chronic hepatitis B. J Hepatol 2001; 34:917-921.
    • (2001) J Hepatol , vol.34 , pp. 917-921
    • Pol, S.1    Nalpas, B.2    Driss, F.3
  • 27
    • 36549028324 scopus 로고    scopus 로고
    • Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: A randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine
    • Vandepapeliè re P, Lau GKK, Leroux-Roels G, et al. Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: a randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine. Vaccine 2007; 25:8585-8597.
    • (2007) Vaccine , vol.25 , pp. 8585-8597
    • Vandepapelière, P.1    Lau, G.K.K.2    Leroux-Roels, G.3
  • 28
    • 4644313122 scopus 로고    scopus 로고
    • Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers
    • Mancini-Bourgine M, Fontaine HLN, Scott-Algara D, et al. Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. Hepatology 2004; 40:874-882.
    • (2004) Hepatology , vol.40 , pp. 874-882
    • Mancini-Bourgine, M.1    Fontaine, H.L.N.2    Scott-Algara, D.3
  • 29
    • 0032769963 scopus 로고    scopus 로고
    • A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group
    • Heathcote J, McHutchison J, Lee S, et al. A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group. Hepatology 1999; 30:531-536.
    • (1999) Hepatology , vol.30 , pp. 531-536
    • Heathcote, J.1    McHutchison, J.2    Lee, S.3
  • 30
    • 84895493744 scopus 로고    scopus 로고
    • Immunological and antiviral responses after therapeutic DNA immunization in chronic hepatitis B patients efficiently treated by analogues
    • Godon O, Fontaine H, Kahi S, et al. Immunological and antiviral responses after therapeutic DNA immunization in chronic hepatitis B patients efficiently treated by analogues. Mol Ther 2013; 22:675-684.
    • (2013) Mol Ther , vol.22 , pp. 675-684
    • Godon, O.1    Fontaine, H.2    Kahi, S.3
  • 31
    • 84926245842 scopus 로고    scopus 로고
    • Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: A randomised trial-ANRS HB02 VAC-AND
    • [Epub ahead of print] This study reported the clinical and virological efficacy of therapeutic vaccination in CHB patients
    • Fontaine H, Kahi S, Chazallon C, et al., ANRS HB02 study group. Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial-ANRS HB02 VAC-ADN. Gut 2014. [Epub ahead of print] This study reported the clinical and virological efficacy of therapeutic vaccination in CHB patients.
    • (2014) Gut
    • Fontaine, H.1    Kahi, S.2    Chazallon, C.3
  • 32
    • 0036337681 scopus 로고    scopus 로고
    • Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: Implications for immunotherapy of persistent viral infections
    • Kakimi K, Isogawa M, Chung J, et al. Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections. J Virol 2002; 76:8609-8620.
    • (2002) J Virol , vol.76 , pp. 8609-8620
    • Kakimi, K.1    Isogawa, M.2    Chung, J.3
  • 33
    • 37349054681 scopus 로고    scopus 로고
    • Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections
    • Depla E, Van der Aa A, Livingston BD, et al. Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections. J Virol 2007; 82:435-450.
    • (2007) J Virol , vol.82 , pp. 435-450
    • Depla, E.1    Van Der Aa, A.2    Livingston, B.D.3
  • 34
    • 84873088935 scopus 로고    scopus 로고
    • A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice
    • Buchmann P, Dembek C, Kuklick L, et al. A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice. Vaccine 2013; 31:1197-1203.
    • (2013) Vaccine , vol.31 , pp. 1197-1203
    • Buchmann, P.1    Dembek, C.2    Kuklick, L.3
  • 35
    • 84904625418 scopus 로고    scopus 로고
    • A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance
    • King TH, Kemmler CB, Guo Z, et al. A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance. PLoS One 2014; 9:e101904.
    • (2014) PLoS One , vol.9 , pp. e101904
    • King, T.H.1    Kemmler, C.B.2    Guo, Z.3
  • 36
    • 84866169967 scopus 로고    scopus 로고
    • DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model
    • Kosinska AD, Johrden L, Zhang E, et al. DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model. J Virol 2012; 86:9297-9310.
    • (2012) J Virol , vol.86 , pp. 9297-9310
    • Kosinska, A.D.1    Johrden, L.2    Zhang, E.3
  • 37
    • 84879549459 scopus 로고    scopus 로고
    • Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model
    • Kosinska AD, Zhang E, Johrden L, et al. Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model. PLoS Pathog 2013; 9:e1003391.
    • (2013) PLoS Pathog , vol.9 , pp. e1003391
    • Kosinska, A.D.1    Zhang, E.2    Johrden, L.3
  • 38
    • 84893805242 scopus 로고    scopus 로고
    • Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection
    • Liu J, Zhang E, Ma Z, et al. Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog 2014; 10:e1003856.
    • (2014) PLoS Pathog , vol.10 , pp. e1003856
    • Liu, J.1    Zhang, E.2    Ma, Z.3
  • 39
    • 84882811237 scopus 로고    scopus 로고
    • Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings
    • Xu DZ, Wang XY, Shen XL, et al. Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings. J Hepatol 2013; 59:450-456.
    • (2013) J Hepatol , vol.59 , pp. 450-456
    • Xu, D.Z.1    Wang, X.Y.2    Shen, X.L.3
  • 40
    • 42249088234 scopus 로고    scopus 로고
    • Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    • Kool M, SoulliéT, van Nimwegen M, et al. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med 2008; 205:869-882.
    • (2008) J Exp Med , vol.205 , pp. 869-882
    • Kool, M.1    Soullié, T.2    Van Nimwegen, M.3
  • 41
    • 84878233150 scopus 로고    scopus 로고
    • Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection
    • Huang LR, Wohlleber D, Reisinger F, et al. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol 2013; 14:574-583.
    • (2013) Nat Immunol , vol.14 , pp. 574-583
    • Huang, L.R.1    Wohlleber, D.2    Reisinger, F.3
  • 42
    • 84884797950 scopus 로고    scopus 로고
    • CD40 activation rescues antiviral CD8+ t cells from PD-1-mediated exhaustion
    • Isogawa M, Chung J, Murata Y, et al. CD40 activation rescues antiviral CD8+ t cells from PD-1-mediated exhaustion. PLoS Pathog 2013; 9:e1003490.
    • (2013) PLoS Pathog , vol.9 , pp. e1003490
    • Isogawa, M.1    Chung, J.2    Murata, Y.3
  • 43
    • 84879601220 scopus 로고    scopus 로고
    • Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance
    • Lan P, Zhang C, Han Q, et al. Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. Hepatology 2013; 58:73-85.
    • (2013) Hepatology , vol.58 , pp. 73-85
    • Lan, P.1    Zhang, C.2    Han, Q.3
  • 44
    • 84893667324 scopus 로고    scopus 로고
    • Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection
    • Lv S, Wang J, Dou S, et al. Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection. Hepatology 2014; 59:385-394.
    • (2014) Hepatology , vol.59 , pp. 385-394
    • Lv, S.1    Wang, J.2    Dou, S.3
  • 45
    • 84883533046 scopus 로고    scopus 로고
    • Mobilizing monocytes to crosspresent circulating viral antigen in chronic infection
    • Gehring AJ, Haniffa M, Kennedy PT, et al. Mobilizing monocytes to crosspresent circulating viral antigen in chronic infection. J Clin Invest 2013; 123:3766-3776.
    • (2013) J Clin Invest , vol.123 , pp. 3766-3776
    • Gehring, A.J.1    Haniffa, M.2    Kennedy, P.T.3
  • 46
    • 84880582625 scopus 로고    scopus 로고
    • T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice
    • Krebs K, Böttinger N, Huang LR, et al. T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology 2013; 145:456-465.
    • (2013) Gastroenterology , vol.145 , pp. 456-465
    • Krebs, K.1    Böttinger, N.2    Huang, L.R.3
  • 47
    • 79958840661 scopus 로고    scopus 로고
    • Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines
    • Gehring AJ, Xue S-A, Ho ZZ, et al. Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines. J Hepatol 2011; 55:103-110.
    • (2011) J Hepatol , vol.55 , pp. 103-110
    • Gehring, A.J.1    Xue, S.-A.2    Ho, Z.Z.3
  • 48
    • 0031005299 scopus 로고    scopus 로고
    • Clearance of hepatitis B surface antigen after bone marrow transplantation: Role of adoptive immunity transfer
    • Lau GK, Lok AS, Liang RH, et al. Clearance of hepatitis B surface antigen after bone marrow transplantation: role of adoptive immunity transfer. Hepatology 1997; 25:1497-1501.
    • (1997) Hepatology , vol.25 , pp. 1497-1501
    • Lau, G.K.1    Lok, A.S.2    Liang, R.H.3
  • 49
    • 59349090822 scopus 로고    scopus 로고
    • Anti-HBs re-seroconversion after liver transplantation in a patient with past HBV infection receiving a HBsAg positive graft
    • Loggi E, Bihl F, Chisholm JV, et al. Anti-HBs re-seroconversion after liver transplantation in a patient with past HBV infection receiving a HBsAg positive graft. J Hepatol 2009; 50:625-630.
    • (2009) J Hepatol , vol.50 , pp. 625-630
    • Loggi, E.1    Bihl, F.2    Chisholm, J.V.3
  • 50
    • 84884227487 scopus 로고    scopus 로고
    • A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus
    • Koh S, Shimasaki N, Suwanarusk R, et al. A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus. Mol Ther Nucleic Acids 2013; 2:e114.
    • (2013) Mol Ther Nucleic Acids , vol.2 , pp. e114
    • Koh, S.1    Shimasaki, N.2    Suwanarusk, R.3
  • 51
    • 0033998463 scopus 로고    scopus 로고
    • Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice
    • Wieland SF, Guidotti LG, Chisari FV. Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J Virol 2000; 74:4165-4173.
    • (2000) J Virol , vol.74 , pp. 4165-4173
    • Wieland, S.F.1    Guidotti, L.G.2    Chisari, F.V.3
  • 52
    • 0033951066 scopus 로고    scopus 로고
    • Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines
    • McClary H, Koch R, Chisari FV, Guidotti LG. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J Virol 2000; 74:2255-2264.
    • (2000) J Virol , vol.74 , pp. 2255-2264
    • McClary, H.1    Koch, R.2    Chisari, F.V.3    Guidotti, L.G.4
  • 53
    • 34447260029 scopus 로고    scopus 로고
    • Tumor necrosis factor activates a conserved innate antiviral response to hepatitis B virus that destabilizes nucleocapsids and reduces nuclear viral DNA
    • Puro R, Schneider RJ. Tumor necrosis factor activates a conserved innate antiviral response to hepatitis B virus that destabilizes nucleocapsids and reduces nuclear viral DNA. J Virol 2007; 81:7351-7362.
    • (2007) J Virol , vol.81 , pp. 7351-7362
    • Puro, R.1    Schneider, R.J.2
  • 54
    • 84887070757 scopus 로고    scopus 로고
    • Interleukin-1 and tumor necrosis factor- A trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID)
    • Watashi K, Liang G, Iwamoto M, et al. Interleukin-1 and tumor necrosis factor- A trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID). J Biol Chem 2013; 288:31715-31727.
    • (2013) J Biol Chem , vol.288 , pp. 31715-31727
    • Watashi, K.1    Liang, G.2    Iwamoto, M.3
  • 55
    • 67349186530 scopus 로고    scopus 로고
    • Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
    • Fisicaro P, Valdatta C, Boni C, et al. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection. Gut 2009; 58:974-982.
    • (2009) Gut , vol.58 , pp. 974-982
    • Fisicaro, P.1    Valdatta, C.2    Boni, C.3
  • 56
    • 84892853405 scopus 로고    scopus 로고
    • Immune therapeutic strategies in chronic hepatitis B virus infection: Virus or inflammation control?
    • Bertoletti A, Gehring AJ. Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control? PLoS Pathog 2013; 9:e1003784.
    • (2013) PLoS Pathog , vol.9 , pp. e1003784
    • Bertoletti, A.1    Gehring, A.J.2
  • 57
    • 84878290084 scopus 로고    scopus 로고
    • Targeting innate immunity: A new step in the development of combination therapy for chronic hepatitis B
    • Zoulim F, Luangsay S, Durantel D. Targeting innate immunity: a new step in the development of combination therapy for chronic hepatitis B. Gastroenterology 2013; 144:1342-1344.
    • (2013) Gastroenterology , vol.144 , pp. 1342-1344
    • Zoulim, F.1    Luangsay, S.2    Durantel, D.3
  • 58
    • 84870539475 scopus 로고    scopus 로고
    • Targeted delivery of interferon- A to hepatitis B virus-infected cells using T-cell receptor-like antibodies
    • Ji C, Sastry KSR, Tiefenthaler G, et al. Targeted delivery of interferon- A to hepatitis B virus-infected cells using T-cell receptor-like antibodies. Hepatology 2012; 56:2027-2038.
    • (2012) Hepatology , vol.56 , pp. 2027-2038
    • Ji, C.1    Sastry, K.S.R.2    Tiefenthaler, G.3
  • 59
    • 84878276077 scopus 로고    scopus 로고
    • GS-9620, an oral agonist of toll-like receptor-7, induces prolonged suppression of hepatitis b virus in chronically infected chimpanzees
    • Lanford RE, Guerra B, Chavez D, et al. GS-9620, an oral agonist of toll-like receptor-7, induces prolonged suppression of hepatitis b virus in chronically infected chimpanzees. Gastroenterology 2013; 144:1508.e10-1517.e10.
    • (2013) Gastroenterology , vol.144 , pp. 1508e10-1517e10
    • Lanford, R.E.1    Guerra, B.2    Chavez, D.3
  • 60
    • 84875466830 scopus 로고    scopus 로고
    • IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells
    • Tang XZ, Jo J, Tan AT, et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol 2013; 190:3142-3152.
    • (2013) J Immunol , vol.190 , pp. 3142-3152
    • Tang, X.Z.1    Jo, J.2    Tan, A.T.3
  • 61
    • 0036839079 scopus 로고    scopus 로고
    • Interleukin-18 inhibits hepatitis b virus replication in the livers of transgenic mice
    • Kimura K, Kakimi K, Wieland S, et al. Interleukin-18 inhibits hepatitis b virus replication in the livers of transgenic mice. J Virol 2002; 76:10702-10707.
    • (2002) J Virol , vol.76 , pp. 10702-10707
    • Kimura, K.1    Kakimi, K.2    Wieland, S.3
  • 62
    • 84875996342 scopus 로고    scopus 로고
    • The third signal cytokine IL-12 rescues the antiviral function of exhausted HBV-specific CD8 T cells
    • Schurich A, Pallett LJ, Lubowiecki M, et al. The third signal cytokine IL-12 rescues the antiviral function of exhausted HBV-specific CD8 T cells. PLoS Pathog 2013; 9:e1003208.
    • (2013) PLoS Pathog , vol.9 , pp. e1003208
    • Schurich, A.1    Pallett, L.J.2    Lubowiecki, M.3
  • 63
    • 84903482908 scopus 로고    scopus 로고
    • Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver
    • Jo J, Tan AT, Ussher JE, et al. Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver. PLoS Pathog 2014; 10:e1004210.
    • (2014) PLoS Pathog , vol.10 , pp. e1004210
    • Jo, J.1    Tan, A.T.2    Ussher, J.E.3
  • 64
    • 84864681003 scopus 로고    scopus 로고
    • Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B
    • Sitia G, Aiolfi R, Di Lucia P, et al. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci U S A 2012; 109:E2165-E2172.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2165-E2172
    • Sitia, G.1    Aiolfi, R.2    Di Lucia, P.3
  • 65
    • 84865504614 scopus 로고    scopus 로고
    • Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B
    • Kennedy PTF, Sandalova E, Jo J, et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B. Gastroenterology 2012; 143:637-645.
    • (2012) Gastroenterology , vol.143 , pp. 637-645
    • Kennedy, P.T.F.1    Sandalova, E.2    Jo, J.3


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