Immunological and antiviral responses after therapeutic DNA immunization in chronic hepatitis B patients efficiently treated by analogues

Molecular Therapy

Volumn 22, Issue 3, 2014, Pages 675-684

  Godon, O ^a   Fontaine, H ^b   Kahi, S ^c   Meritet, J F ^d   Scott Algara, D ^a   Pol, S ^b   Michel, M L ^a   Bourgine, M ^a  

^a INSTITUT PASTEUR   (France)

^b INSTITUT COCHIN   (France)

^c INSERM   (France)

^d université Paris Cité   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE;

ADAPTIVE IMMUNITY; ADULT; ANTIBODY TITER; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA IMMUNIZATION; DRUG EFFICACY; EX VIVO STUDY; FEMALE; HEPATITIS B; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHENOTYPE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEROLOGY; T LYMPHOCYTE; TREATMENT DURATION; VIROLOGY; VIRUS REACTIVATION;

HEPATITIS B VIRUS;

ADULT; AGED; COMBINED MODALITY THERAPY; DNA, VIRAL; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERFERON-GAMMA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; T-LYMPHOCYTES; VACCINES, DNA; VIRAL ENVELOPE PROTEINS; VIRAL LOAD;

EID: 84895493744     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.274     Document Type: Article

References (23)

1. Lok, AS and McMahon, BJ (2007). Chronic hepatitis B. Hepatology 45: 507-539.
2. Boni, C, Fisicaro, P, Valdatta, C, Amadei, B, Di Vincenzo, P, Giuberti, T et al. (2007). Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 81: 4215-4225.
3. Rehermann, B and Nascimbeni, M (2005). Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5: 215-229.
4. Dunn, C, Peppa, D, Khanna, P, Nebbia, G, Jones, M, Brendish, N et al. (2009). Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 137: 1289-1300.
5. Boni, C, Penna, A, Bertoletti, A, Lamonaca, V, Rapti, I, Missale, G et al. (2003). Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B. J Hepatol 39: 595-605.
6. Mancini-Bourgine, M, Fontaine, H, Scott-Algara, D, Pol, S, Bréchot, C and Michel, ML (2004). Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. Hepatology 40: 874-882.
7. Scott-Algara, D, Mancini-Bourgine, M, Fontaine, H, Pol, S and Michel, ML (2010). Changes to the natural killer cell repertoire after therapeutic hepatitis B DNA vaccination. PLoS ONE 5: e8761.
8. Boni, C, Laccabue, D, Lampertico, P, Giuberti, T, Viganò, M, Schivazappa, S et al. (2012). Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues. Gastroenterology 143: 963-73.e9.
9. Cooksley, H, Chokshi, S, Maayan, Y, Wedemeyer, H, Andreone, P, Gilson, R et al. (2008). Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4+ T-cell reactivity. Antimicrob Agents Chemother 52: 312-320.
10. Jiang, Y, Ma, Z, Xin, G, Yan, H, Li, W, Xu, H et al. (2010). Th1 and Th2 immune response in chronic hepatitis B patients during a long-term treatment with adefovir dipivoxil. Mediators Inflamm 2010: 143026.
11. Webster, GJ, Reignat, S, Brown, D, Ogg, GS, Jones, L, Seneviratne, SL et al. (2004). Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 78: 5707-5719.
12. Zajac, AJ, Murali-Krishna, K, Blattman, JN and Ahmed, R (1998). Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells. Curr Opin Immunol 10: 444-449.
13. Lopes, AR, Kellam, P, Das, A, Dunn, C, Kwan, A, Turner, J et al. (2008). Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J Clin Invest 118: 1835-1845.
14. Schurich, A, Khanna, P, Lopes, AR, Han, KJ, Peppa, D, Micco, L et al. (2011). Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis- Prone CD8 T cells in persistent hepatitis B virus infection. Hepatology 53: 1494-1503.
15. Holz, LE, Benseler, V, Bowen, DG, Bouillet, P, Strasser, A, O'Reilly, L et al. (2008). Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death. Gastroenterology 135: 989-997.
16. Micco, L, Peppa, D, Loggi, E, Schurich, A, Jefferson, L, Cursaro, C et al. (2013). Differential boosting of innate and adaptive antiviral responses during pegylated interferon-alpha therapy of chronic hepatitis B. J Hepatol 58: 225-233.
17. Wherry, EJ, Blattman, JN and Ahmed, R (2005). Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination. J Virol 79: 8960-8968.
18. Hadziyannis, SJ, Sevastianos, V, Rapti, I, Vassilopoulos, D and Hadziyannis, E (2012). Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir. Gastroenterology 143: 629-36.e1.
19. European Association For The Study Of The Liver. (2012). EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. J Hepatol 57: 167-185.
20. Halfon, P, Bourlière, M, Pol, S, Benhamou, Y, Ouzan, D, Rotily, M et al. (2006). Multicentre study of hepatitis B virus genotypes in France: correlation with liver fibrosis and hepatitis B e antigen status. J Viral Hepat 13: 329-335.
21. Michel, ML, Deng, Q and Mancini-Bourgine, M (2011). Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: perspectives and challenges. J Hepatol 54: 1286-1296.
22. Mancini-Bourgine, M, Fontaine, H, Bréchot, C, Pol, S and Michel, ML (2006). Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers. Vaccine 24: 4482-4489.
23. Bayard, F, Godon, O, Nalpas, B, Costentin, C, Zhu, R, Soussan, P et al. (2012). T-cell responses to hepatitis B splice-generated protein of hepatitis B virus and inflammatory cytokines/chemokines in chronic hepatitis B patients. ANRS study: HB EP 02 HBSPFIBRO. J Viral Hepat 19: 872-880.