Structure, biochemistry, and inhibition of essential 4′-phosphopantetheinyl transferases from two species of Mycobacteria

ACS Chemical Biology

Volumn 9, Issue 9, 2014, Pages 1939-1944

  Vickery, Christopher R ^a,c   Kosa, Nicolas M ^a   Casavant, Ellen P ^a   Duan, Shiteng ^a   Noel, Joseph P ^b,c   Burkart, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' PHOSPHOPANTETHEINYL TRANSFERASE; PANTETHEINE PHOSPHATE; SURFACTIN BIOSYNTHESIS; TRANSFERASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ENZYME INHIBITOR; MOLECULAR LIBRARY; PHOSPHOPANTETHEINYL TRANSFERASE; PHOSPHOTRANSFERASE;

ARTICLE; BACTERIAL CELL WALL; BIOCHEMISTRY; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM ULCERANS; NONHUMAN; PROTEIN FUNCTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; FLUORESCENCE POLARIZATION; GENETICS; METABOLISM; MOLECULAR LIBRARY; MUTATION; PHARMACOLOGY; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CORYNEBACTERINEAE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FLUORESCENCE POLARIZATION; MODELS, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM ULCERANS; PROTEIN CONFORMATION; SMALL MOLECULE LIBRARIES; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 84913601701     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500263p     Document Type: Article

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