PRC1 complex diversity: Where is it taking us?

Trends in Cell Biology

Volumn 24, Issue 11, 2014, Pages 632-641

  Gil, Jesús ^a   O'Loghlen, Ana ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

CBX; Chromobox protein; KDM2; Polycomb; PRC1

Indexed keywords

BMI1 PROTEIN; HISTONE DEACETYLASE 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYCOMB GROUP PROTEIN; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR TWIST; UVOMORULIN; CHROMATIN;

BINDING AFFINITY; CANCER GROWTH; CELL FATE; CELL PROLIFERATION; CHROMATIN; CHROMATIN STRUCTURE; DISEASE COURSE; ENZYME ACTIVITY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; LUNG CARCINOMA; MULTIPLE MYELOMA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SENESCENCE; TRANSCRIPTION INITIATION; UPREGULATION; X CHROMOSOME INACTIVATION; ANIMAL; CELL AGING; GENETICS; MOUSE; NEOPLASM;

MAMMALIA;

ANIMALS; CELL AGING; CHROMATIN; HUMANS; MICE; NEOPLASMS; POLYCOMB REPRESSIVE COMPLEX 1; POLYCOMB-GROUP PROTEINS;

EID: 84927693660     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2014.06.005     Document Type: Review

References (79)

1. Chen T., Dent S.Y.R. Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat. Rev. Genet. 2014, 15:93-106.
2. Di Croce L., Helin K. Transcriptional regulation by Polycomb group proteins. Nat. Struct. Mol. Biol. 2013, 20:1147-1155.
3. Musselman C.A., et al. Perceiving the epigenetic landscape through histone readers. Nat. Struct. Mol. Biol. 2012, 19:1218-1227.
4. Schwartz Y.B., Pirrotta V. A new world of Polycombs: unexpected partnerships and emerging functions. Nat. Rev. Genet. 2013, 14:853-864.
5. Simon J.A., Kingston R.E. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat. Rev. Mol. Cell Biol. 2009, 10:697-708.
6. Vandamme J., et al. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol. Cell. Proteomics 2011, 10:1-23. M110 002642.
7. Morey L., et al. RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells. Cell Rep. 2013, 3:60-69.
8. Tavares L., et al. RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell 2012, 148:664-678.
9. Gao Z., et al. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol. Cell 2012, 45:344-356.
10. O'Loghlen A., et al. MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell 2012, 10:33-46.
11. Luis N.M., et al. Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of cbx4. Cell Stem Cell 2011, 9:233-246.
12. Pemberton H., et al. Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts. Genome Biol. 2014, 15:R23.
13. Tan J., et al. CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell 2011, 20:563-575.
14. Klauke K., et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat. Cell Biol. 2013, 15:353-362.
15. Morey L., et al. Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. Cell Stem Cell 2012, 10:47-62.
16. Bernstein E., et al. Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol. Cell. Biol. 2006, 26:2560-2569.
17. Min J., et al. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 2003, 17:1823-1828.
18. Fischle W., et al. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev. 2003, 17:1870-1881.
19. Vincenz C., Kerppola T.K. Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:16572-16577.
20. Frangini A., et al. The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. Mol. Cell 2013, 51:647-661.
21. Kondo T., et al. Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev. Cell 2014, 28:94-101.
22. Yang L., et al. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 2011, 147:773-788.
23. Yu M., et al. Direct recruitment of Polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol. Cell 2012, 45:330-343.
24. Xu K., et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 2012, 338:1465-1469.
25. Brookes E., et al. Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs. Cell Stem Cell 2012, 10:157-170.
26. Wu X., et al. Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol. Cell 2013, 49:1134-1146.
27. He J., et al. Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat. Cell Biol. 2013, 15:373-384.
28. Farcas A.M., et al. KDM2B links the Polycomb repressive complex 1 (PRC1) to recognition of CpG islands. Elife 2012, 1:e00205.
29. Barrero M.J., Izpisua Belmonte J.C. Polycomb complex recruitment in pluripotent stem cells. Nat. Cell Biol. 2013, 15:348-350.
30. Qin J., et al. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 2012, 11:319-332.
31. Trojer P., et al. L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol. Cell 2011, 42:438-450.
32. van Deursen J.M. The role of senescent cells in ageing. Nature 2014, 509:439-446.
33. Dietrich N., et al. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J. 2007, 26:1637-1648.
34. Gil J., et al. Polycomb CBX7 has a unifying role in cellular lifespan. Nat. Cell Biol. 2004, 6:67-72.
35. Bracken A.P., et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21:525-530.
36. Yap K.L., et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol. Cell 2010, 38:662-674.
37. Maertens G.N., et al. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PloS ONE 2009, 4:e6380.
38. Forzati F., et al. CBX7 is a tumor suppressor in mice and humans. J. Clin. Invest. 2012, 122:612-623.
39. Tzatsos A., et al. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zeste homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J. Biol. Chem. 2011, 286:33061-33069.
40. Tzatsos A., et al. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2641-2646.
41. He J., et al. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat. Struct. Mol. Biol. 2008, 15:1169-1175.
42. El Messaoudi-Aubert S., et al. Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor. Nat. Struct. Mol. Biol. 2010, 17:862-868.
43. Bracken A.P., Helin K. Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat. Rev. Cancer 2009, 9:773-784.
44. Yang M-H., et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat. Cell Biol. 2010, 12:982-992.
45. Negishi M., et al. A novel zinc finger protein Zfp277 mediates transcriptional repression of the INK4a/Arf locus through polycomb repressive complex 1. PLoS ONE 2010, 5:1-14.
46. Martin N., et al. Interplay between homeobox proteins and Polycomb repressive complexes in p16INKa regulation. EMBO J. 2013, 32:982-995.
47. Federico A., et al. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Cancer Res. 2009, 69:7079-7087.
48. Scott C.L., et al. Role of the chromobox protein CBX7 in lymphomagenesis. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:5389-5394.
49. Jacobs J.J., et al. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999, 397:164-168.
50. Dhawan S., et al. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 2009, 23:906-911.
51. Gargiulo G., et al. In vivo RNAi screen for BMI1 targets identifies TGF-b/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell 2013, 23:660-676.
52. Piunti A., et al. Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication. Nat. Commun. 2014, 5:3649.
53. Chubb D., et al. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat. Genet. 2013, 45:1221-1225.
54. Maethner E., et al. MLL-ENL inhibits Polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells. Cell Rep. 2013, 1:1-14.
55. Smith L-L., et al. Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells. Cell Stem Cell 2011, 8:649-662.
56. Li J., et al. Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. Cancer Cell 2014, 25:118-131.
57. He J., et al. KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. Blood 2011, 117:3869-3880.
58. Kottakis F., et al. FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Mol. Cell 2011, 43:285-298.
59. Dhar S.S., et al. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer Cells. J. Biol. Chem. 2014, 289:7483-7496.
60. Wagner K.W., et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J. Clin. Invest. 2013, 123:5231-5246.
61. Liu B., et al. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development 2013, 140:780-788.
62. Katoh-Fukui Y., et al. Male-to-female sex reversal in M33 mutant mice. Nature 1998, 393:688-692.
63. Katoh-Fukui Y., et al. Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Endocrinology 2012, 153:913-924.
64. Liang G., et al. Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Nat. Cell Biol. 2012, 14:649.
65. Augui S., et al. Regulation of X-chromosome inactivation by the X-inactivation centre. Nat. Rev. Genet. 2011, 12:429-442.
66. Koren A., McCarroll S.A. Random replication of the inactive X chromosome. Genome Res. 2014, 24:64-69.
67. Escamilla-Del-Arenal M., et al. Cdyl, a new partner of the inactive X chromosome and potential reader of H3K27me3 and H3K9me2. Mol. Cell. Biol. 2013, 33:5005-5020.
68. Simon J.A., Kingston R.E. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol. Cell 2013, 49:808-824.
69. Voncken J.W., et al. Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:2468-2473.
70. Biason-Lauber A., et al. Ovaries and female phenotype in a girl with 46, XY karyotype and mutations in the CBX2 gene. Am. J. Hum. Genet. 2009, 84:658-663.
71. Pirity M.K., et al. Rybp/DEDAF is required for early postimplantation and for central nervous system development. Mol. Cell. Biol. 2005, 25:7193-7202.
72. Marson A., et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008, 134:521-533.
73. Overhoff M.G., et al. Cellular senescence mediated by p16INK4A-coupled miRNA pathways. Nucleic Acids Res. 2013, 1:1-13.
74. Roscic A., et al. Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. Mol. Cell 2006, 24:77-89.
75. Wu H-A., et al. MAP kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. J. Biol. Chem. 2013, 288:36398-36408.
76. Coré N., et al. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 1997, 124:721-729.
77. Skarnes W.C., et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 2011, 474:337-342.
78. White J.K., et al. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell 2013, 154:452-464.
79. Fukuda T., et al. Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol. Cell. Neurosci. 2011, 46:614-624.