FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway

Molecular Cell

Volumn 43, Issue 2, 2011, Pages 285-298

  Kottakis, Filippos ^a   Polytarchou, Christos ^a   Foltopoulou, Parthena ^a   Sanidas, Ioannis ^a   Kampranis, Sotirios C ^a   Tsichlis, Philip N ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 2; HISTONE H3; MICRORNA; MICRORNA 101; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NEOPLASM; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN RNA BINDING; PROTEIN STABILITY;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DNA-BINDING PROTEINS; F-BOX PROTEINS; FIBROBLAST GROWTH FACTOR 2; HISTONE DEMETHYLASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MICE; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; OXIDOREDUCTASES, N-DEMETHYLATING; TRANSCRIPTION FACTORS;

EID: 79960469058     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2011.06.020     Document Type: Article

References (32)

1. Aerts S., Thijs G., Coessens B., Staes M., Moreau Y., De Moor B. Toucan: deciphering the cis-regulatory logic of coregulated genes. Nucleic Acids Res. 2003, 31:1753-1764.
2. Aerts S., Van Loo P., Thijs G., Mayer H., de Martin R., Moreau Y., De Moor B. TOUCAN 2: the all-inclusive open source workbench for regulatory sequence analysis. Nucleic Acids Res. 2005, 33(Web Server issue). W393-6.
3. Bracken A.P., Kleine-Kohlbrecher D., Dietrich N., Pasini D., Gargiulo G., Beekman C., Theilgaard-Mönch K., Minucci S., Porse B.T., Marine J.C., et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21:525-530.
4. Cao R., Wang L., Wang H., Xia L., Erdjument-Bromage H., Tempst P., Jones R.S., Zhang Y. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002, 298:1039-1043.
5. Cao Y., Cao R., Hedlund E.M. R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways. J. Mol. Med. 2008, 86:785-789.
6. Dvorak P., Dvorakova D., Hampl A. Fibroblast growth factor signaling in embryonic and cancer stem cells. FEBS Lett. 2006, 580:2869-2874.
7. Fahmy R.G., Khachigian L.M. Suppression of growth factor expression and human vascular smooth muscle cell growth by small interfering RNA targeting EGR-1. J. Cell. Biochem. 2007, 100:1526-1535.
8. Friedman J.M., Liang G., Liu C.C., Wolff E.M., Tsai Y.C., Ye W., Zhou X., Jones P.A. The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res. 2009, 69:2623-2629.
9. Gil J., Bernard D., Peters G. Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol. 2005, 24:117-125.
10. Hara F., Samuel S., Liu J., Rosen D., Langley R.R., Naora H. A homeobox gene related to Drosophila distal-less promotes ovarian tumorigenicity by inducing expression of vascular endothelial growth factor and fibroblast growth factor-2. Am. J. Pathol. 2007, 170:1594-1606.
11. Herz H.M., Shilatifard A. The JARID2-PRC2 duality. Genes Dev. 2010, 24:857-861.
12. Holland E.C., Varmus H.E. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc. Natl. Acad. Sci. USA 1998, 95:1218-1223.
13. Iliopoulos D., Polytarchou C., Hatziapostolou M., Kottakis F., Maroulakou I.G., Struhl K., Tsichlis P.N. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci. Signal. 2009, 2:ra62.
14. Kampranis S.C., Tsichlis P.N. Histone demethylases and cancer. Adv. Cancer Res. 2009, 102:103-169.
15. Land H., Parada L.F., Weinberg R.A. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983, 304:596-602.
16. Lee Y., Samaco R.C., Gatchel J.R., Thaller C., Orr H.T., Zoghbi H.Y. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat. Neurosci. 2008, 11:1137-1139.
17. Liu N., Lu M., Tian X., Han Z. Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J. Cell. Physiol. 2007, 211:279-286.
18. Lu C., Han H.D., Mangala L.S., Ali-Fehmi R., Newton C.S., Ozbun L., Armaiz-Pena G.N., Hu W., Stone R.L., Munkarah A., et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell 2010, 18:185-197.
19. MacFarlane, L., and Murphy, P. (2010). FGF2 (fibroblast growth factor 2 (basic)). Atlas Genet Cytogenet Oncol Haematol. http://AtlasGeneticsOncology.org/Genes/FGF2ID511ch4q27.html.
20. Niemistö A., Dunmire V., Yli-Harja O., Zhang W., Shmulevich I. Robust quantification of in vitro angiogenesis through image analysis. IEEE Trans. Med. Imaging 2005, 24:549-553.
21. Pfau R., Tzatsos A., Kampranis S.C., Serebrennikova O.B., Bear S.E., Tsichlis P.N. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc. Natl. Acad. Sci. USA 2008, 105:1907-1912.
22. Polytarchou C., Pfau R., Hatziapostolou M., Tsichlis P.N. The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Mol. Cell. Biol. 2008, 28:7451-7464.
23. Sanderson R.D., Yang Y., Kelly T., MacLeod V., Dai Y., Theus A. Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies. J. Cell. Biochem. 2005, 96:897-905.
24. Schlessinger J. Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 2004, 306:1506-1507.
25. Schuettengruber B., Chourrout D., Vervoort M., Leblanc B., Cavalli G. Genome regulation by polycomb and trithorax proteins. Cell 2007, 128:735-745.
26. Simon J.A., Kingston R.E. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat. Rev. Mol. Cell Biol. 2009, 10:697-708.
27. Tan J., Yang X., Zhuang L., Jiang X., Chen W., Lee P.L., Karuturi R.K., Tan P.B., Liu E.T., Yu Q. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007, 21:1050-1063.
28. Tzatsos A., Pfau R., Kampranis S.C., Tsichlis P.N. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc. Natl. Acad. Sci. USA 2009, 106:2641-2646.
29. Varambally S., Cao Q., Mani R.S., Shankar S., Wang X., Ateeq B., Laxman B., Cao X., Jing X., Ramnarayanan K., et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008, 322:1695-1699.
30. Wiedłocha A., Sørensen V. Signaling, internalization, and intracellular activity of fibroblast growth factor. Curr. Top. Microbiol. Immunol. 2004, 286:45-79.
31. Wu X., Chen H., Parker B., Rubin E., Zhu T., Lee J.S., Argani P., Sukumar S. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition. Cancer Res. 2006, 66:9527-9534.
32. Yang E.J., Ahn Y.S., Chung K.C. Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells. J. Biol. Chem. 2001, 276:39819-39824.