Inhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling

Cell Death and Disease

Volumn 5, Issue 11, 2014, Pages

  Gong, Y ^a   Xu, C Y ^a   Wang, J R ^a   Hu, X H ^a   Hong, D ^b   Ji, X ^a   Shi, W ^a   Chen, H X ^b   Wang, H B ^c   Wu, X M ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE   (China)

^c INSTITUTE OF ZOOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIC GMP DEPENDENT PROTEIN KINASE 2; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SECRETED FRIZZLED RELATED PROTEIN 1; TADALAFIL; VARDENAFIL; CARBOLINE DERIVATIVE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; FRZB PROTEIN; GLYCOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; BONE MARROW DERIVED STROMAL CELL; BONE MASS; CELL DIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LONG TERM CARE; MOUSE; NONHUMAN; OSTEOBLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STROMA CELL; TRABECULAR BONE; TREATMENT DURATION; WILD TYPE; WNT SIGNALING PATHWAY; ANATOMY AND HISTOLOGY; ANIMAL; BONE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FEMUR; METABOLISM; ORGAN SIZE; OSTEOBLAST; PROTEIN STABILITY;

ANIMALIA; MUS;

ANIMALS; BETA CATENIN; BONE AND BONES; CARBOLINES; CELL DIFFERENTIATION; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; FEMUR; GLYCOPROTEINS; HEK293 CELLS; HUMANS; MICE; ORGAN SIZE; OSTEOBLASTS; PHOSPHODIESTERASE 5 INHIBITORS; PROTEIN STABILITY; TADALAFIL; WNT SIGNALING PATHWAY;

EID: 84927669546     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.510     Document Type: Article

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